TRADITIONAL POSTER - ismrm

Poster Sessions
conventional (XRT+cytotoxic) or adjuvant anti-angiogenic therapy. A decrease in vascularization was observed early in adjuvant anti-angiogenic therapy.
Progression-free survival status of patients receiving anti-angiogenic therapy may be dominated by an initial change in leakage, while PFS of patients
receiving conventional therapy is not. This work highlights the need for further functional imaging techniques for the evaluation of response.
2171. Parametric Response Map as an Imaging Biomarker to Distinguish Progression from
Pseudoprogression in High Grade Gliomas
Christina Tsien 1 , Craig J. Galban 1 , Thomas L. Chenevert 1 , Timothy D. Johnson 1 , Daniel A. Hamstra 1 , Pia
C. Sundgren 1 , Larry Junck 1 , Charles R. Meyer 1 , Alnawaz Rehemtulla 1 , Theodore Lawrence 1 , Brian D.
Ross 1
1 University of Michigan, Ann Arbor, MI, United States
We have developed a reliable method for distinguishing true progression from pseudoprogression by quantifying on a voxel-wise basis therapeuticassociated
hemodynamic alterations in patients with high grade glioma. The parametric response map of rCBV (PRM rCBV ) at week 3 during chemoradiation
is shown to be a potential early imaging biomarker of response that may be helpful in distinguishing pseudoprogression from true progression in patients
with high grade glioma.
2172. Quantitative Metrics Derived from DCE MRI as a Biomarker for Early Response to Radiation
Therapy in Brain Metastases
Yue Cao 1 , Felix Y. Feng, Diana Gomez-Hassan 2 , James A. Hayman, Theodore S. Lawrence, Christina I.
Tsien
1 Radiology and Radiation Oncology, University of Michigan, Ann Arbor, MI, United States; 2 Radiology, University of Michigan, Ann
Arbor, MI, United States
The response of metastatic lesions to whole brain radiation therapy (WBRT) is highly heterogeneous. In this study, we evaluated quantitative metrics
derived from DCE MRI for early assessment of response of brain metastatic lesions to WBRT. We found that changes in vascular volume and perfusion at
the completion of WBRT differentiated responsive lesions from non-responsive ones. These DCE metrics have the potential for early prediction of
treatment response in brain metastases. This requires further validation, but may provide a means for individualizing therapy in patients with brain
metastases by selecting patients requiring treatment intensification with stereotactic RT.
2173. Dynamic Contrast Enhanced and Susceptibility Based CBV Measurements Perform Equally in
Grading of Cerebral Gliomas
Muftah Ahmed Manita 1 , Paul Morgan 2 , Keith Robson 3 , Timothy Jaspan 3 , Dorothee P. Auer 1
1 Academic Radiology, University of Nottingham, Nottingham, United Kingdom; 2 Radiology & Radiological Science, Medical
University of South Carolina, United States; 3 Nottingham University Hospital, United Kingdom
Perfusion MRI DSC (T2*) has shown added values in glioma tumour differentiation with rCBVmax is the best performing metrics obtained from dynamic
susceptibility contrast technique (DSC). However, this technique is susceptible to blood leak that results in rCBV overestimation. T1 MRI perfusion (DCE)
is not susceptible to vascular disruption. Nineteen patients with low and high grade glioma underwent MR perfusion (T1 and T2*) was analysed with Java
image software. Significant difference (P=0.000) with excellent correlation (0.81) between the two tumour grades in both techniques with accuracy of 100%.
T1 based DCE is robust technique to follow postoperative cases.
2174. Enhancing Fraction and Survival in Glioblastoma Multiforme
Samantha Jane Mills 1,2 , Calvin Soh 2 , Gerard Thompson 1 , Giovanni Buonaccorsi 1 , Catherine McBain 3 , Sha
Zhao 1 , Geoff James Martin Parker 1 , Alan Jackson 1,2
1 Imaging Science and Biomedical Engineering, University of Manchester, Manchester, Greater Manchester, United Kingdom;
2 Department of Neuroradiology, Salford Royal Foundation Trust Hospital, Salford, Greater Manchester, United Kingdom;
3 Department of Clinical Oncology, Christie Hospital, Manchester, Greater Manchester, United Kingdom
This study describes the relationship between the DCE-MRI derived measure, Enhancing Fraction, and overall survival in patients with Glioblastoma
Multiforme, with the findings of increased survival in association with elevated Enhancing Fraction.
Imaging of Brain Tumors: Techniques & Contrast Media
Hall B Tuesday 13:30-15:30
2175. Delta T1 Method: An Automatic Post-Contrast ROI Selection Technique for Brain Tumors
Devyani Bedekar 1,2 , Todd Jensen 3 , Scott Rand 1,4 , Mark Malkin, 2,5 , Jennifer Connelly, 2,5 , Kathleen
Schmainda, 2,6
1 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 2 Translational Brain Tumor Research Program, Medical
College of Wisconsin, Milwaukee, WI, United States; 3 Imaging Biometrics, Milwaukee, WI, United States; 4 Translational Brain
Tumor Research Program, Medical College of Wisconsin, Milwaukee, WI, United States; 5 Neurology, Medical College of Wisconsin,
Milwaukee, WI, United States; 6 Radiology & Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States
The primary approach to monitoring patients with brain tumors is to obtain pre and post-contrast T1-weighted images. Bright areas on the pre-contrast
images are suggestive of blood products, which may be a result or treatment, and are therefore not to be considered as enhancing lesions on the post-contrast
images. However, the difference between the brightness that exists on both the post and pre-contrast images can be quite subtle, a condition that is occurring
more frequently now with the increasing use of anti-angiogenic agents. Therefore it is becoming increasingly difficult to monitor patients with brain tumors
simply by visually comparing differences in enhancement. As a solution in this report we propose an automatic method, the delta T1 method (dTM), which