TRADITIONAL POSTER - ismrm

Poster Sessions
designed to approximate a binge drinking episode. Signal changes in the brain and uterus/placenta were compared using a pulse sequence protocol with high
temporal and spatial resolution, showing that gadodiamide entered fetal cerebral circulation following alcohol administration.
Multiple Sclerosis
Hall B Monday 14:00-16:00
2067. 7 Tesla 3D-FLAIR and 3D-DIR: High Sensitivity in Cortical Regions in Multiple Sclerosis
Wolter L. de Graaf 1 , F. Visser 2,3 , M. P. Wattjes 1 , J. Geurts 4 , P. Pouwels 5 , C. H. Polman 6 , F. Barkhof 1 , P. R.
Luijten 2 , J. A. Castelijns 1
1 Radiology, VU University Medical Center, Amsterdam, Netherlands; 2 Image Science Institute, University Medical Center Utrecht,
Utrecht, Netherlands; 3 PHILIPS Healthcare; 4 Pathology, VU University Medical Center, Amsterdam, Netherlands; 5 Physics and
Medical Technology, VU University Medical Center, Amsterdam, Netherlands; 6 Neurology, VU University Medical Center,
Amsterdam, Netherlands
MR diagnostics in Multiple Sclerosis have benefited from sequences like fluid attenuated inversion recovery (FLAIR) and double inversion recovery (DIR),
that increase sensitivity especially in cortical regions. We demonstrate use of 3D (isotropic) FLAIR, DIR and T1-weighted clinically feasible imaging at 7
Tesla. Images were read for the number of lesions visible in the regular classifications for the several sequences. Results were also compared with images
obtained from the same patients at 3 Tesla. A large sensitivity increase especially in cortical regions was found at 7 Tesla for all 3D sequences. 3D-FLAIR
however, proofed to be the most sensitive.
2068. 3D Magnetization Prepared Double Inversion Recovery (3D MP-DIR) at 7 Tesla
Frederik Visser 1,2 , Jaco J M Zwanenburg 1 , Wolter L. de Graaf 3 , J A. Castelijns 3 , Peter R. Luijten 1
1 UMC, Utrecht, Netherlands; 2 PHILIPS Healthcare; 3 VU UMC Amsterdam
Dedicated magnetization preparation pre-pulses (MP) have been designed to acquire high resolution 3D DIR images covering the whole brain at 7-Tesla.The
ability to detect sub-millimeter cortical and/or sub cortical lesions has great potential for future clinical studies.
2069. Cortical Lesions in MS: Assessment at 7T
Kathrine T. Bluestein 1 , Cherian Renil Zachariah 1 , Steffen Sammet 1 , Devin Elizabeth Prior 1 , David Pitt 2 ,
Aaron Boster 2 , Amir Abduljalil 1 , Michael V. Knopp 1 , Petra Schmalbrock 1
1 Department of Radiology, The Ohio State University, Columbus, OH, United States; 2 Department of Neurology, The Ohio State
University, Columbus, OH, United States
Assessment of cortical lesions in MS is of significant interest, because correlation of conventional MRI with clinical findings is limited. However, detection
of cortical lesions has been hampered by their small size and low contrast. In this study, we assessed cortical lesion detection in 7 MS patients and healthy
controls at 7T using high resolution 3D T2* weighted, white matter attenuated (WHAT) turbo field echo and T1-weighted IR-TFE imaging. Cortical lesions
were best seen with the WHAT sequence, and there was little reader variability.
2070. High Resolution Magnetization Transfer Imaging at 7T : Detection of Cortical Lesions in MS Patient
Olivier E. Mougin 1 , Jennifer Dixon 1 , Ian Donaldson 2 , Emma Tallantyre 2 , Nikos Evangelou 2 , Penny A.
Gowland 1
1 Sir Peter Mansfield Magnetic Resonance Centre, School of Physics & Astronomy,University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom; 2 Institute of Neuroscience, Nottingham, Nottinghamshire, United Kingdom
This study aims to detect cortical lesions in MS patients. High resolution MTR scans (0.5mm isotropic, as well as 0.35mm in plane resolution) have been
acquired at 7T using a novel imaging sequence. The MTR contrast has been compared between white matter and grey matter, showing a greater grey matter
(GM) / white matter (WM) contrast to noise ratio at 7T, providing a good delineation of WM and GM lesions at high resolution with the MTR contrast. The
sequence is being used to study changes in the cortex of MS patients.
2071. Surface-Based Analysis of Subpial T2*signal Changes at 7T in Multiple Sclerosis
Julien Cohen-Adad 1,2 , Douglas Greve 1,2 , Thomas Benner 1,2 , Amy Radding 1,2 , R Philip Kinkel, 2,3 , Bruce R.
Rosen 1,2 , Bruce Fischl 1,2 , Caterina Mainero 1,2
1 A. A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Charlestown, MA, United States; 2 Harvard Medical
School, Boston, MA, United States; 3 Beth Israel Deaconess Medical Center, Boston, MA, United States
The ability to detect and to classify in vivo gray matter (GM) lesions in multiple sclerosis (MS) is required to better understand pathological processes
associated with disease progression and disability. In this paper we combined ultra high field MRI (7T) with surface-based analysis to achieve quantitative
assessment of subtle and diffuse cortical changes in multiple sclerosis (MS). Results show a significant increase of the T2* signal in MS patients versus
controls. This increase may reflect the diffuse subpial pathology that has been described in autopsy cases of MS. Surface-based analysis facilitates the
characterization of cortical lesions in vivo.
2072. What Does (Quantitative) MRI of the MS Cortical Gray Matter Measure? a Post Mortem Imaging
Exploration.
Alexandra Marion Seewann 1,2 , Hugo Vrenken 3,4 , Evert-Jan Kooi 5 , Paul van der Valk 5 , Dirk Knol 6 , Chris
Polman 1 , Petra Pouwels 4 , Frederik Barkhof 3 , Jeroen Geurts, 3,5
1 Neurology, VU University medical center, Amsterdam, Netherlands; 2 Neurology, Medical University Graz, Graz, Austria;
3 Radiology, VU University medical center, Amsterdam, Netherlands; 4 Physics and Medical Technology, VU University medical