TRADITIONAL POSTER - ismrm

Poster Sessions
2277. Investigation of Tissue Plasticity Following Low-Dose Amphetamine Treatment in Transient Ischemic
Rat Stroke Model Using Diffusion Tensor Imaging
Hua-Shan Liu 1 , Hui Shen 1 , Hanbing Lu 1 , Jenny Chou 1 , April P. Zhu 1 , William Rea 1 , Yun Wang 1 , Yihong
Yang 1
1 National Institute on Drug Abuse, Baltimore, MD, United States
There is considerable evidence to suggest that amphetamine can improve functional outcome in animal model of stroke, which is involved in the
mechanisms of induced axonal growth and reinnervation of brain tissues. In this study we used DTI to assess changes in perilesional tissue integrity after
amphetamine treatment in a rat stroke model. We found that FA showed a significantly higher increase under the influence of amphetamine after 25 days.
2278. Learning Is Necessary for Training Induced Brain Plasticity
Jason Philipp Lerch 1 , Amanpreet Badhwar 2,3 , Edith Hamel 2 , John G. Sled 1
1 Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2 McGill University, Montreal, Quebec, Canada; 3
(contributed equally to this abstract)
Here we used a mouse model of Alzheimer’s Disease (AD) with impaired spatial learning to test whether a capacity to learn is necessary for training induced
MRI detectable volume changes to occur. Mice were trained on two different versions of the Morris Water Maze, fixation perfused and scanned overnight at
32 µm isotropic resolution. As hypothesized, hippocampal based spatial learning was impaired in AD mice, whereas striatum dependent non-spatial learning
was equivalent between AD and wild-type mice. The data presented herein thus indicates that learning is a requirement for MRI detectable plasticity.
fMRI in Brain Diseases
Hall B Monday 14:00-16:00
2279. Functional Asymmetry of Hippocampal Subfields in Tempoal Lobe Epilepsy: An Application of
Postmortem Atlas
Sandhitsu R. Das 1 , Dawn Mechanic-Hamilton 2 , Marc Korczykowski 2 , John Pluta 2 , John A. Detre 2 , Paul A.
Yushkevich 1
1 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 Department of Neurology, University of
Pennsylvania, Philadelphia, PA, United States
We present preliminary data demonstrating the use of postmortem hippocampus atlas to study activation asymmetry in patients with unilateral temporal lobe
epilepsy
2280. Spatiotemporal Network Alterations in Experimental Focal Cortical Epilepsy: MRI-Based
Longitudinal Functional Connectivity and Weighted Graph Analysis
Willem M. Otte 1,2 , Rick M. Dijkhuizen 2 , Cornelis J. Stam 3 , Kajo van der Marel 2 , Maurits P.A. van Meer 1,2 ,
Max A. Viergever 2 , Kees P.J. Braun 1
1 Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands; 2 Image Sciences Institute,
University Medical Center Utrecht, Utrecht, Netherlands; 3 Department of Clinical Neurophysiology, VU University Medical Center,
Amsterdam, Netherlands
There is increasing evidence that the topology of brain networks may be changed in epilepsy. In particular, a random topology has been suggested as an
explanation for lower seizure thresholds. To test this hypothesis, we assessed focal epileptic and healthy networks over time using resting state functional
MRI and weighted graph theoretical analysis in a rat model. Brain networks in focal epilepsy were globally affected, toward a more ordered network
topology. Networks largely normalized at ten weeks after epilepsy induction. Graph analysis provides a promising method to explore dynamical network
alterations in epilepsy.
2281. Role of Resting State Functional Connectivity Mri in Presurgical Investigation of Mesial Temporal
Lobe Epilepsy
Gaelle Bettus 1,2 , Fabrice Bartolomei 2 , Sylviane Confort-Gouny 1 , Eric Guedj 1 , Patrick Chauvel 2 , Patrick
Cozzone 1 , Jean-Philippe Ranjeva 1 , Maxime Guye 1
1 CNRS UMR6612 CRMBM-CEMEREM, Marseille, France; 2 INSERM U751 Epilepsie et Cognition, Marseille, France
We aimed at determining the ability of resting-state functional connectivity MRI (fcMRI) to lateralize/localize the epileptogenic zone in mesial temporal
lobe epilepsy (MTLE) at the individual level. Basal functional connectivity (BFC) was evaluated in 22 MTLE patients compared to 36 controls using a
single shot GE-EPI sequence at rest. In patients, BFC was characterized by bilateral decreases predominant in the epileptic side, and unilateral increases
almost exclusively observed in the contralateral (non-epileptic) side. We suggest that fcMRI is a useful technique that could be added to the presurgical
assessment of drug-resistant partial epilepsies.
2282. Analysis of Simultaneous EEG/fMRI Data in Epileptic Patients Using ICA and GLM Based Methods.
Marco Carnì 1,2 , Carlo Di Bonaventura 3 , Giovanni Giulietti 4 , Jinan Fattouch 5 , Anna Teresa Giallonardo 6 ,
Anna Elisabetta Vaudano 6 , Valter Nucciarelli 6 , Mario Manfredi 6 , Massimiliano Prencipe 6 , Vittorio
Cannatà 1 , Bruno Maraviglia 2
1 Department of Occupational and safety- Medical Physics-, Bambino Gesù Children's Ospital,Scientific Istitute (IRCCS), Rome, Italy;
2 Department of Physics University of Rome “La Sapienza”, MARBILab Enrico Fermi Center, Rome, Italy; 3 Department of
Neurology,, University of Rome “Sapienza”, Rome, Italy; 4 Department of Physics University of Rome “La Sapienza”, MARBILab