TRADITIONAL POSTER - ismrm

Poster Sessions
1189. Detectability of the BOLD Signal
Jozien Goense 1 , Hellmut Merkle 2 , Nikos Logothetis 1,3
1 Department of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany;
2 Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States; 3 Division of Imaging Science and
Biomedical Engineering, University of Manchester, Manchester, United Kingdom
The BOLD signal is a weak signal, and hence if no BOLD signal is found in an area this does not necessarily mean there is no neural activity in that area.
Signal dropout, artifacts, instability, physiological noise, RF-coil inhomogeneity etc. can all reduce the SNR locally leading to decreased detectability of the
BOLD signal Here we illustrate that calculation of the spatial distribution of the detection for a given set of experimental conditions allows us to estimate the
confidence by which absence of an fMRI signal can be interpreted as an absence of neural activity.
1190. BOLD FMRI of Anesthetized Baboons
Hsiao-Ying Wey 1,2 , Jinqi Li 1 , M. Michelle Leland 3 , Lisa Jones 3 , C Akos Szabo 4 , John W. Roby 1 , James T.
Scribner 1,2 , Ghzawan M. Kroma 2 , Peter T. Fox 1 , Timothy Q. Duong 1,2
1 Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States; 2 Radiology, UT Health
Science Center at San Antonio, San Antonio, TX, United States; 3 Laboratory Animal Resources, UT Health Science Center at San
Antonio, San Antonio, TX, United States; 4 Neurology, UT Health Science Center at San Antonio, San Antonio, TX, United States
This study reports a robust anesthetized baboon model for BOLD fMRI studies on a clinical 3T human MRI scanner. BOLD fMRI of visual and
somatosensory/motor stimulations in anesthetized baboons were investigated. Comparisons of BOLD fMRI sensitivity were made between isoflurane and
ketamine anesthetics with and without paralytics. To our knowledge, this is the first report on baboon BOLD fMRI of visual and somatosensory/motor.
1191. Using T 1 Map to Guide Functional MRI Study of Ipsilateral Somatosensory Cortex in Awake Non-
Human Primates
Junjie V. Liu 1 , Nicholas A. Bock 2 , Ara Kocharyan 1 , Julie Mackel 1 , Afonso C. Silva 1
1 NINDS, National Institutes of Health, Bethesda, MD, United States; 2 Medical Physics, McMaster University, Hamilton, ON, Canada
By combining BOLD fMRI with T1 mapping, here we study the ipsilateral responses in somatosensory cortex of awake marmosets. Our results show a
surprising spatial mismatch between contralateral and ipsilateral representations of the same body part.
1192. Fine -Scale Functional Connectivity Network Revealed at High Field (9.4T) Within Somatosensory
Cortices of Anesthetized New World Monkeys
Arabinda Mishra 1 , Baxter P. Rogers 1 , Barbara Dillenburger 1 , Kevin Wilson 1 , Feng Wang 1 , John C. Gore 1 ,
Li Min Chen 1
1 Radiology & Radiological Science, VUIIS, Nashville, TN, United States
Correlations between resting state BOLD signals in widely distributed brain regions is a key signature of consciously driven mental activity in humans. In
this work we attempted to explore if a fine scale functional connectivity can be detected within the anatomically well defined primary somatosensory cortex
(SI) at high field and whether the functional connectivity reflects anatomical hierarchical relationships in anesthetized monkeys. We found that functional
connectivity exists among anatomically interconnected cortical subregions (areas 3a, 3b, 1 and 2) within SI without the involvement of consciousness (or
alertness), and the strengths of the correlation among these subregions reflect the strength of their underlying anatomical connections.
1193. fMRI Analysis of the Olfactory Responses to Home-Stream Water in Sockeye Salmon
Hiroshi Bandoh 1 , Ikuhiro Kida 2 , Hiroshi Ueda 1,3
1 Division of Environmental Science Development, Graduate School of Environmental Science, Hokkaido University, Sapporo,
Hokkaido, Japan; 2 Integrated Neuroscience Research Team, Tokyo Institute of Pschiatry, Setagaya-ku, Tokyo, Japan; 3 Laboratory of
Aquatic Ecosystem Conservation, Field Science Center for Northern Biosphere, Hokkaido University, Sapporo, Hokkaido, Japan
The odor-information processing involved in olfactory imprinting and homing of the home-stream odor in the central nervous system of salmon has not been
completely elucidated. In this study, to investigate this information-processing mechanism, we used BOLD fMRI to measure the response to home-stream
water in the olfactory bulb and telencephalon of sockeye salmon. The presence of BOLD signals in the dorsal area of the telencephalon indicated that the
odor information for home-stream water was processed in a specific area in the telencephalon of sockeye salmon.
1194. Evaluation of Functional Deficit and Recovery in the Rat Somatosensory Cortex After Moderate
Traumatic Brain Injury Using FMRI
Juha-Pekka Niskanen 1,2 , Antti Airaksinen 1 , Jari Nissinen 1 , Asla Pitkänen 1 , Olli Gröhn 1
1 Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland; 2 Department of
Physics, University of Kuopio, Kuopio, Finland
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. In this study, 10 rats with TBI and 6 sham operated controls were imaged
during electrical stimulation of the forepaws before TBI and 1, 2 and 8 weeks after TBI. fMRI with forepaw stimulation was able to reveal functional deficit
after TBI in the somatosensory cortex outside of the main lesion and also detect partial sensory recovery 8 weeks after TBI. The results suggest that fMRI
could serve as a non-invasive user independent tool to evaluate functional recovery after TBI.