TRADITIONAL POSTER - ismrm

Poster Sessions
1969. Regional and Global Cerebral Blood Flow Is Reduced in Patients with Post-Stroke Dementia
Jiabao He 1 , Michael J. Firbank 2 , Rajesh N. Kalaria 2 , Baldev Singh 2 , Paul Danson 2 , John O'Brien 2 , Andrew
M. Blamire 1
1 Newcastle MR Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; 2 Institute
for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
Stroke is one of the most important risk factors for dementia. In stroke survivors who do not have immediate, severe cognitive impairment, the risk of
developing dementia is significantly increased. Stroke may also exacerbate or trigger the development of neurodegenerative pathology. Small vessel
vascular effects may be an important factor in neurodegeneration. We compared CBF in post-stroke patients with and without cognitive decline, patients
with Alzheimer’s disease and healthy controls. Regional and global deficits in CBF were found in patients with post-stroke dementia resembling patterns of
change in AD patients, while cognitively intact post-stroke patients had normal CBF.
1970. The Effects of ApoE4 Allele and Age on Subcortical Brain Atrophy in HIV Positive Subjects
Linda Chang 1 , Marilou Andres 2 , Jeff Sadino 1 , Caroline Jiang 1 , Helenna Nakama 3 , Ute Feger 1 , Thomas
Ernst 1
1 Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States; 2 Pacific
Biomedical Research Center, University of Hawaii at Manoa, Honolulu, HI, United States; 3 Department of Psychiatry, John A. Burns
School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States
The presence of apolipoprotein (Apo) E4 allele may accelerate the progression of HIV disease, and increase the risk for developing HIV associated
neurocognitive disorder (HAND). Whether Apo E4 allele and age may influence subcortical brain atrophy in HIV patients are unknown and were evaluated
in this study. Smaller subcortical structures were found in HIV patients with HAND, less so in those with normal cognition. ApoE4 genotype was
associated with greater atrophic effects in the younger but not older HIV patients, which suggests that ongoing neuro-inflammatory processes may be more
robust and have stronger deleterious effects in the younger patients.
1971. Increased Folding Complexity of the Left Temporal Pole in Temporal Lobe Epilepsy
Natalie L. Voets 1,2 , Boris C. Bernhardt 2 , Hosung Kim 2 , Andrea Bernasconi 2
1 University of Oxford FMRIB Centre, Oxford, Oxfordshire, United Kingdom; 2 Montreal Neurological Institute and Hospital, McGill
University, NeuroImaging of Epilepsy Laboratory and McConnell Brain Imaging Centre, Montreal, Quebec, Canada
Converging histological and radiological data suggest neurodevelopmental abnormalities may play a role in the pathogenesis of drug-resistant temporal lobe
epilepsy (TLE). Using surface-based cortical curvature measures, we identified abnormally increased cortical folding in the left temporal pole of patients
with both left and right TLE as compared to healthy controls. Increased left temporopolar folding was associated with abnormal positioning of the ipsilateral
hippocampus in left TLE patients, and associated with unfavourable surgical outcome in patients with a right-sided seizure focus. These results suggest
abnormalities in global limbic network connectivity may play an important role in temporal lobe epileptogenesis.
1972. 1H NMR Metabolomics Study of Cerebrospinal Fluid (CSF) in Amyotrophic Lateral Sclerosis (ALS)
Patients
Lydie Nadal-Desbarats 1 , Helène Blasco 2 , Segolene Veau 2 , Patrick Vourc'h 2 , Caroline Moreau 3 , David
Devos 3 , Philippe Corcia 4 , Christian R. Andres 2
1 Laboratoire de RMN, INSERM U930 - CNRS 2448 - Université François Rabelais, Tours, France; 2 Laboratoire de Biochimie et
Biologie moleculaire, Inserm U930-CNRS 2448 - Université François Rabelais, Tours, France; 3 Service de Neurologie et Pathologie
du Mouvement, EA2683, Hopital R. Salengro - CHRU Lille, Lille, France; 4 Centre SLA, CHRU Bretonneau, Tours, France
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease. Pathophysiological mechanisms involved in this disease are complex but remain
for the most part unknown. This lack of knowledge might explain the absence of reliable biological marker. CSF could be a source of biomarkers. The aim
of this study was to analyze CSF of patients with ALS by 1H NMR in order to identify biomarkers in the early stage of the disease, and to evaluate the
biochemical factors involved in this disease. We quantified 18 metabolites like amino-acids, organic acids and ketonic bodies. Higher concentrations of
metabolites such as ketone bodies contribute to the PCA separation between the two populations.
1973. T 1 -Weighted Images Detect Motor Neuron Degeneration in ALS
Govind Nair 1 , John D. Carew 2,3 , Sharon Usher 4 , Michael Benatar 4,5 , Xiaoping P. Hu 1
1 Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States; 2 Institute
for Health Studies, Carolinas HealthCare System, Charlotte, NC, United States; 3 School of Public Health, Emory University, Atlanta,
GA, United States; 4 Department of Neurology, Emory University, Atlanta, GA, United States; 5 Department of Epidemiology, Emory
University, Atlanta, GA, United States
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease affecting the motor neurons in the brain and spinal cord. VBM analysis
performed on T1-weighted images of the brain revealed significant changes in the motor cortex and supporting white matter of ALS patients compared with
age-matched healthy control subjects. ROI analysis revealed a significant decrease in signal intensity from these regions, with signal intensity of ALS group
showing significant correlation with clinical measures of disease severity. These findings suggest that T1-weighted images may have utility as an imaging
biomarker of disease progression in ALS.