TRADITIONAL POSTER - ismrm

Poster Sessions
2684. Measuring Glomerular Protein Leakage with Dual-Agent DCE-MRI: Reproducibility in Healthy Pigs
Mike Notohamiprodjo 1 , Michael Pedersen 2 , Klaus-Peter Lodemann 3 , Maximilian F. Reiser, Christian
Glaser, Steven P. Sourbron
1 Institute for Clinical Radiology, University Hospitals Munich, Munich, Bavaria, Germany; 2 Skejby Sygehus Aarhus, Aarhus,
Denmark; 3 BRACCO S.p.a.
In this study a method is proposed to detect albumin leakage across the glomerular membrane with DCE-MRI. Four healthy piglets were examined with a
dual-agent protocol with the contrast agent Gd-DTPA and the albumin-bound Gd-BOPTA. The small variability in the GFR values indicates that the
measurement approach may be sufficiently precise to detect subtle variations in Gd-BOPTA relaxivity due to increased albumine leakage. This technique
may help detecting such diseases in an early stage, where tubular reabsorption of albumine masks the leakage in urine samples. Further studies in a model
with albumine leakage is warranted.
2685. Counting Total Number of Kidney Glomeruli Using MRI
Scott Charles Beeman 1 , Megan Henriksen 1 , David Frakes 1 , Kevin M. Bennett 1
1 Bioengineering, Arizona State University, Tempe, AZ, United States
We present a method for counting number of renal glomeruli using MRI. Rats were given intravenous injections of CF followed by resection of kidneys. Ex
vivo Imaging revealed spots of hypointensity throughout the cortex of the kidney due to accumulation of CF in the glomerular basement membrane,
consistent with individual glomeruli. Thresholding techniques applied to the image volumes yielded a glomerular count of 43,362 glomeruli. This is in
agreement with and lies within 10% of a histological count of 39,514 glomeruli in the contralateral kidney, indicating an accurate glomerular count of the
whole kidney.
2686. Segmentation of Kidney Cortex and Medulla on MR Images by Use of Multi-Feature K-Means Method
Yin Huang 1 , Deborah Yagow 2 , Nathan Artz 1 , Elizabeth Sadowski 3 , Arjang Djamali 4 , Sean Fain 1
1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2 Biomedical Engineering, University of Wisconsin-
Madison, Madison, WI, United States; 3 Radiology, University of Wisconsin-Madison, Madison, WI, United States; 4 Nephrology,
University of Wisconsin-Madison, Madison, WI, United States
The K-means segmentation method was implemented to automatically segment kidney cortex and medulla on MR images of 24 subjects based on two
kidney feature values -- T1 and perfusion weighted information. Manual segmentation results on the same subjects were used as reference and three
similarity measures were calculated to evaluate the effectiveness of K-means segmentation. The segmentation time was radically shortened by K-means
compared with manual operation. However, there are about 30% of all subjects that K-means segmentation did not work well so that a semi-automated
strategy can be suggested to incorporate manual segmentation when necessary.
2687. Changes in Kidney Volume in Experimental PKD Quantified by a Clinical 3T MR Scanner
Sheryl Foster 1 , Mayuresh S. Korgaonkar 2 , Gopi K. Rangan 3 , Kristina G. Schwensen 3 , Anthony Peduto 1
1 Radiology, Westmead Hospital, University of Sydney, Australia; 2 Brain Dynamics Center, Westmead Millennium Institute,
Westmead, NSW, Australia; 3 Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney,
Australia
The goal of this study was to assess the feasibility of using a 3T whole body clinical scanner along with a conventional available wrist coil in a longitudinal
study of drug treatment in small rodents. We studied longitudinal kidney structural changes in rodents with Polycystic Kidney Disease (PKD); and also
evaluated the effect of sirolimus treatment, an immunosuppressant drug currently used in clinical trials in humans with PKD, during early disease on the
progression of kidney enlargement in this animal model.
2688. Comparison of DCE-MRI and DCE-CT in Patients with Renal Cell Carcinoma: Effects of Temporal
Resolution and Total Measurement Time
Colleen Bailey 1,2 , Mostafa Atri 3 , Georg A. Bjarnason 1 , Greg J. Stanisz 1,2
1 Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2 University of Toronto, Toronto, ON, Canada; 3 University Health
Network, Toronto, ON, Canada
Patients with renal cell carcinoma were scanned with DCE-MRI (temporal resolution 3.7 s) and DCE-CT (temporal resolution 1 s). ROIs across the tumour
volume were analyzed using the Kety-Tofts two-compartment model of perfusion. The volume transfer constant, K trans , did not correlate between the two
modalities. The extravascular extracellular volume, v e , showed weak correlation. Undersampling the DCE-CT data to similar temporal resolution as the
DCE-MRI data systematically underestimated K trans , whereas restricting the DCE-MRI data, initially acquired over five minutes, to the two minute
acquisition time of the DCE-CT data resulted in a systematic underestimation of v e and an overestimation of K trans .
2689. Seminal Vesicle Dilatation in Autosomal Dominant Polycystic Kidney Disease
Beatriu Reig 1 , Jon Blumenfeld 2,3 , Stephanie Donahue 3 , Wei Zhang, Martin R. Prince
1 Department of Radiology, Weill Cornell Medical College, New York, NY, United States; 2 Department of Medicine, Weill Cornell
Medical College; 3 The Rogosin Institute
Seminal vesicle dilatation, a probable cause of infertility in men with autosomal dominant polycystic kidney disease (ADPKD), is characterized in this
review of 47 male ADPKD patients undergoing MRI. Comparison is made to a cohort of age-matched controls.