TRADITIONAL POSTER - ismrm

Poster Sessions
High Resolution Brain Imaging
Hall B Tuesday 13:30-15:30
2304. Patch Structure in White Matter Detected by Microscopic MRI at High Field Strength
Tie-Qiang Li 1 , M. Fukunaga 2 , K Shmueli1 2 , S Dodd 2 , J H. Duyn 2
1 Department of Medical Physics, Karolinska University Hospital, S-141 86, Stockholm, Sweden; 2 Laboratory of Functional and
Molecular Imaging,, National Institute of Neurological Disorders and Stroke, National Institutes of Health,, United States
T2*-weighted MRI at high magnetic field strength has recently been used to reveal cortical layer structures and white matter heterogeneity in vivo. Magnetic
susceptibility differences have been widely thought to give rise to most of the contrast but the precise mechanisms underlying the contrast is still poorly
understood. Here, we report an interesting finding from microscopic MRI and histological studies of white matter specimens of the human brain, which may
provide further clues for better understanding of the mechanisms underlying the T2*-weighted contrast.
2305. MR Contrast in Post-Mortem Brain Remains After 6 Decades of Storage: Imaging in Cerebellar
Agenesis
Stephen J. Sawiak 1,2 , Guy B. Williams 1 , T Adrian Carpenter 1 , S A. Edgley 3
1 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; 2 Behavioural and Clinical Neurosciences
Institute, University of Cambridge, Cambridge, United Kingdom; 3 Department of Physiology, Development and Neuroscience,
University of Cambridge, Cambridge, United Kingdom
Cerebellar agenesis is a condition where the cerebellum fails to develop normally. Here we present data from two individuals acquired post-mortem from
brains extracted in the 1940s showing high resolution anatomical and structural data with MPRAGE and DTI sequences.
2306. Measuring Cortical Thickness of the Human Brain Using Ultra High Resolution Data
Falk Lüsebrink 1 , Astrid Wollrab 2
1 RheinAhrCampus, Remagen, Germany; 2 Biomedical Magnetic Resonance, Otto-von-Guericke-Universität, Magdeburg, Germany
The analysis of the human cerebral cortex and the measurement of its thickness based on MRI data provide insight into normal brain development and
neurodegenerative disorders. Accurate and reproducible results of the cortical thickness measurement are desired. In addition to data processing tools, the
quality (i.e. resolution) of the imaging data is evaluated. We thus compare ultra high resolution data acquired at 7T with 3T data for measuring the cortical
thickness of the human brain.
2307. Effect of Head Motion on the MRI Visibility of Cortical Layers in Human Primary Visual Cortex
Jessica Schulz 1 , Miriam Wähnert 1 , Robert Trampel 1 , Robert Turner 1
1 Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
There is increased interest in using ultra-high-field brain MRI to map intracortical structures. We simulated the effect on layer structure of small in-plane
motions during data sampling, using 200 micron resolution ex vivo brain images. Such motions can easily introduce illusory structures, shown in images and
cortical intensity profiles of human primary visual cortex, without and with motion corruption. Our simulations emphasize the crucial importance of
appropriate motion correction of high resolution brain data.
2308. Sub-Millimeter Isotropic Ocular-Dominance Mapping at 7T Using 3D EPI
Natalia Petridou 1 , Ben M. Harvey 2 , Serge O. Dumoulin 2 , S F.W. Neggers 3 , Tjerk Gutteling 3 , Peter Luijten 1 ,
Hans Hoogduin 1
1 UMC Utrecht, Utrecht, Netherlands; 2 Psychology, Utrecht University, Utrecht, Netherlands; 3 Rudolf Magnus Institute for
Neuroscience, UMC Utrecht, Utrecht, Netherlands
The advent of high fields has made it possible to reconstruct the functional organization of ocular-dominance columns in the human cortex with submillimeter
in-plane (2D) resolution. However, 2D-based imaging techniques necessarily use anisotropic spatial resolution and are restricted to subjects that
have relatively flat regions of cortex. Using 3D EPI with sub-millimeter isotropic resolution at 7T and a differential ocular stimulation we found alternating
activation patterns in V1 which may relate to the expected ocular-dominance column distribution. This suggests that at 7T, 3D EPI can offer an avenue for
sub-millimeter isotropic mapping not limited by the underlying anatomy.
2309. Optic Nerve Characterisation by Isotropic High-Resolution MRI
Sandro Romanzetti 1 , Petra Stoerig 2 , Ana Maria Oros-Peusquens 1 , N. Jon Shah 1,3
1 Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Juelich, Juelich, Germany; 2 Institut für
Experimentelle Psychologie, Heinrich-Heine-Universität, Duesseldorf, Germany; 3 Faculty of Medicine, Department of Neurology,
RWTH Aachen, Aachen, Germany
Many ophthalmological and neurological pathologies affect the optic nerve which provides the brain with retinal information. Revealing their
manifestations with isotropic, high-resolution imaging of the optic nerve, the orbit and the chiasm may allow early and direct diagnosis of diseases that result
in loss of visual function, partial or complete blindness. In this pilot study, we present isotropic, high-resolution optic nerve images which may be suitable
for clinical applications.