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Poster Sessions<br />

2162. Altered Cortical Thickness in Young Cannabis Abusers<br />

Deborah Yurgelun-Todd 1,2 , Piotr Bogorodzki 3 , Melissa Lopez-Larson 1,2 , Robert Kurjata 3 , John<br />

Churchwell 1 , Jadwiga Rogowska 4<br />

1 Brain Institute, University of Utah, Salt Lake City, UT, United States; 2 VISN 19 MIRECC, Salt Lake City, UT, United States;<br />

3 Institute of Radioelectronics, Warsaw Technical University, Warsaw, Poland; 4 Brain Imaging Center, McLean Hospital/Harvard<br />

Medical School, Belmont, MA, United States<br />

It is unknown whether altered cortical thickness during adolescence is associated with marijuana (MJ) use. This investigation used cortical-surface based<br />

techniques to compare MJ using adolescents and healthy controls (HC). Eighteen adolescents with DSM-IV MJ Dependence and 18 HCs had an MRI scans<br />

using a 3T Siemens Trio scanner. Cortical reconstruction and volumetric segmentation was performed with the Freesurfer image analysis suite. Compared to<br />

HCs, MJ users had decreased cortical thickness in bilateral superior frontal cortex and bilateral and left insula. Furthermore, the average thickness of the<br />

right insula was found to negatively correlate with age of first MJ use.<br />

2163. Perfusion Deficit to Cholinergic Challenge in Veterans with Gulf War Illness<br />

Peiying Liu Wang 1 , Sina Aslan 1 , Xiufeng Li 2 , David Buhner 3 , Richard Briggs 2 , Robert Haley 3 , Hanzhang<br />

Lu 1<br />

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Department of<br />

Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3 Department of Internal Medicine,<br />

University of Texas Southwestern Medical Center, Dallas, TX, United States<br />

A highly plausible etiology for the Gulf War Illness (GWI) is that the neural damage and cognitive deficits are associated with excessive exposure to<br />

cholinesterase-inhibiting cholinergic stimulants. Our previous SPECT study provided strong indication that cerebral blood flow of veterans with Syndrome 2<br />

GWI has reduced responses to cholinergic challenge, compared to unaffected control veterans. The present study confirmed and extended previous findings<br />

that patients with Gulf War Illness have abnormal response to an inhibitory cholinergic challenge, physostigmine infusion, when compared to age-gendereducation<br />

matched control veterans. This new technique may provide a cost-effective biomarker for characterization of Gulf war illness.<br />

2164. Cortical GABA and Glutamate Changes in Posttraumatic Stress Disorder<br />

Anderson Mon 1,2 , Thomas Neylan 3 , Dieter Meyerhoff 1,4<br />

1 Radiology, University of California, San Francisco, San Francisco, CA, United States; 2 Center for Imaging of Neurodegenerative<br />

Diseases, Veteran Administration Medical Center, San Francisco, CA; 3 Psychiatry, University of California, San Francisco, San<br />

Francisco, CA, United States; 4 Center for Imaging of Neurodegenerative Diseases, Veteran Administration Medical Center, San<br />

Francisco, CA, United States<br />

We studied NAA, Glu and GABA levels in post traumatic stress disorder using magnetic resonance spectroscopy. We found lower NAA in the anterior<br />

cingulate, lower GABA in the posterior occipital cortex, and lower GABA and higher Glu in the medial temporal lobe as compared to control subjects.<br />

Metabolite levels related to PTSD symptomatology and suggest neuronal injury, perhaps associated with excitatory and inhibitory processes in cortical brain<br />

Clinical Brain Tumor Imaging: Anatomic, MT, SWI & Perfusion MRI<br />

Hall B Monday 14:00-16:00<br />

2165. Potential Utility of Quantitative Magnetisation Transfer Imaging for Detection of Lesion Extent in<br />

Glioblastoma Multiforme<br />

Gerard Thompson 1,2 , Sha Zhao 1,2 , Samantha J. Mills 1,2 , John R. Cain 1,2 , Geoff J M Parker 1,2 , Alan<br />

Jackson 1,2<br />

1 Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 2 Biomedical Imaging<br />

Institute, University of Manchester, Manchester, United Kingdom<br />

Glioblastoma multiforme is an aggressive primary brain tumour, which invades preferentially along white matter tracts. Histopathological and PET evidence<br />

suggests that at the time of diagnosis, infiltrating tumour already exists at sites distant from the enhancing tumour visible on conventional anatomical MR<br />

imaging. Since MR is used to plan radiotherapy and surgery, there is concern that infiltrating tumour may be missed, and may therefore escape optimal<br />

treatment. We provide preliminary evidence in two cases that quantitative magnetisation transfer (qMT) imaging can detect changes in white matter adjacent<br />

to glioblastoma which appear otherwise normal on conventional MR imaging.

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