TRADITIONAL POSTER - ismrm

Poster Sessions
2162. Altered Cortical Thickness in Young Cannabis Abusers
Deborah Yurgelun-Todd 1,2 , Piotr Bogorodzki 3 , Melissa Lopez-Larson 1,2 , Robert Kurjata 3 , John
Churchwell 1 , Jadwiga Rogowska 4
1 Brain Institute, University of Utah, Salt Lake City, UT, United States; 2 VISN 19 MIRECC, Salt Lake City, UT, United States;
3 Institute of Radioelectronics, Warsaw Technical University, Warsaw, Poland; 4 Brain Imaging Center, McLean Hospital/Harvard
Medical School, Belmont, MA, United States
It is unknown whether altered cortical thickness during adolescence is associated with marijuana (MJ) use. This investigation used cortical-surface based
techniques to compare MJ using adolescents and healthy controls (HC). Eighteen adolescents with DSM-IV MJ Dependence and 18 HCs had an MRI scans
using a 3T Siemens Trio scanner. Cortical reconstruction and volumetric segmentation was performed with the Freesurfer image analysis suite. Compared to
HCs, MJ users had decreased cortical thickness in bilateral superior frontal cortex and bilateral and left insula. Furthermore, the average thickness of the
right insula was found to negatively correlate with age of first MJ use.
2163. Perfusion Deficit to Cholinergic Challenge in Veterans with Gulf War Illness
Peiying Liu Wang 1 , Sina Aslan 1 , Xiufeng Li 2 , David Buhner 3 , Richard Briggs 2 , Robert Haley 3 , Hanzhang
Lu 1
1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2 Department of
Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3 Department of Internal Medicine,
University of Texas Southwestern Medical Center, Dallas, TX, United States
A highly plausible etiology for the Gulf War Illness (GWI) is that the neural damage and cognitive deficits are associated with excessive exposure to
cholinesterase-inhibiting cholinergic stimulants. Our previous SPECT study provided strong indication that cerebral blood flow of veterans with Syndrome 2
GWI has reduced responses to cholinergic challenge, compared to unaffected control veterans. The present study confirmed and extended previous findings
that patients with Gulf War Illness have abnormal response to an inhibitory cholinergic challenge, physostigmine infusion, when compared to age-gendereducation
matched control veterans. This new technique may provide a cost-effective biomarker for characterization of Gulf war illness.
2164. Cortical GABA and Glutamate Changes in Posttraumatic Stress Disorder
Anderson Mon 1,2 , Thomas Neylan 3 , Dieter Meyerhoff 1,4
1 Radiology, University of California, San Francisco, San Francisco, CA, United States; 2 Center for Imaging of Neurodegenerative
Diseases, Veteran Administration Medical Center, San Francisco, CA; 3 Psychiatry, University of California, San Francisco, San
Francisco, CA, United States; 4 Center for Imaging of Neurodegenerative Diseases, Veteran Administration Medical Center, San
Francisco, CA, United States
We studied NAA, Glu and GABA levels in post traumatic stress disorder using magnetic resonance spectroscopy. We found lower NAA in the anterior
cingulate, lower GABA in the posterior occipital cortex, and lower GABA and higher Glu in the medial temporal lobe as compared to control subjects.
Metabolite levels related to PTSD symptomatology and suggest neuronal injury, perhaps associated with excitatory and inhibitory processes in cortical brain
Clinical Brain Tumor Imaging: Anatomic, MT, SWI & Perfusion MRI
Hall B Monday 14:00-16:00
2165. Potential Utility of Quantitative Magnetisation Transfer Imaging for Detection of Lesion Extent in
Glioblastoma Multiforme
Gerard Thompson 1,2 , Sha Zhao 1,2 , Samantha J. Mills 1,2 , John R. Cain 1,2 , Geoff J M Parker 1,2 , Alan
Jackson 1,2
1 Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 2 Biomedical Imaging
Institute, University of Manchester, Manchester, United Kingdom
Glioblastoma multiforme is an aggressive primary brain tumour, which invades preferentially along white matter tracts. Histopathological and PET evidence
suggests that at the time of diagnosis, infiltrating tumour already exists at sites distant from the enhancing tumour visible on conventional anatomical MR
imaging. Since MR is used to plan radiotherapy and surgery, there is concern that infiltrating tumour may be missed, and may therefore escape optimal
treatment. We provide preliminary evidence in two cases that quantitative magnetisation transfer (qMT) imaging can detect changes in white matter adjacent
to glioblastoma which appear otherwise normal on conventional MR imaging.