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Poster Sessions<br />

1999. Rates of Brain Tissue Changes in the General Population of Elderly - The AGES-Reykjavik Study<br />

Sigurdur Sigurdsson 1 , Thor Aspelund 1,2 , Lars Forsberg 3 , Jesper Fredriksson 3 , Olafur Kjartansson, 1,4 ,<br />

Palmi V. Jonsson, 1,4 , Gudny Eiriksdottir 1 , Tamara B. Harris 5 , Alex Zijdenbos 6 , Mark A. van Buchem 7 ,<br />

Lenore J. Launer 5 , Vilmundur Gudnason 1,2<br />

1 The Icelandic Heart Association, Kopavogur, Iceland; 2 The University of Iceland, Reykjavik, Iceland; 3 Raforninn Inc, Reykjavik,<br />

Iceland; 4 The University Hospital of Iceland, Reykjavik, Iceland; 5 The National Institute on Aging, Bethesda, United States;<br />

6 Biospective Inc, Montreal, Canada; 7 Leiden University Medical Center, Leiden, Netherlands<br />

Estimations on age-related rate of changes of brain tissues have mostly been gathered from cross-sectional MRI studies. A limitation of cross-sectional<br />

design is the inability to directly assess intra-individual change. Longitudinal studies on brain tissues and age in large population cohorts are lacking. We<br />

compared estimated rates of cross-sectional and longitudinal changes with age in brain tissues in a population-based cohort of 4614 older persons. The<br />

longitudinal data show a substantially higher age-related rate of change in tissue volumes when compared to the cross-sectional estimates and show that the<br />

cross-sectional data underestimates the rate of change in brain tissues.<br />

2000. Effects of Sex and Age on Regional Frontal Lobe Gray Matter Distribution<br />

Vanessa Anne Sluming 1,2 , Andrew Mayes 3 , Iain D. Wilkinson 4 , Charles Romanowski 4 , Enis Cezayirli 5 ,<br />

Patricia E. Cowell 6<br />

1 School of Health Sciences, University of Liverpool, Liverpool, Merseyside, United Kingdom; 2 Magnetic Resonance and Image<br />

Analysis Research Centre, University of Liverpool, Liverpool, Merseyside, United Kingdom; 3 School of Psychology, University of<br />

Manchester, Manchester, United Kingdom; 4 Academic Department of Radiology, University of Sheffield, United Kingdom;<br />

5 Department of Anatomy, University of Celal Bayar , Turkey; 6 Department of Human Communication Sciences, University of<br />

Sheffield, United Kingdom<br />

VBM analysis of grey matter distribution within the healthy adult brain was undertaken, in a sample of 31 males and 35 females (age range: 20-72 years) to<br />

investigate sex differences in the effect of brain ageing. Data were analysed using a full factorial analysis (2x2x2). There were no significant sex by age<br />

effects. Within sex regression analyses revealed that females showed age related GM decrements within several frontal regions tending medially, whereas<br />

males sowed age related decrements in bilateral structures including IFG (BA44/45). These findings are discussed.<br />

2001. White Matter Lesion Intensity and Cognitive Ability: Relationships in Youth and Old Age<br />

Maria Valdés Hernandez 1 , Lars Penke 2 , Susana Muñoz Maniega 1 , Catherine Murray 2 , Natalie Royle 1 , Alan<br />

J. Gow 2 , John M. Starr 3 , Mark E. Bastin 4 , Ian J. Deary 2 , Joanna M. Wardlaw 1<br />

1 Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom; 2 Psychology, University of Edinburgh, Edinburgh,<br />

United Kingdom; 3 Geriatric Medicine, University of Edinburgh, Edinburgh, United Kingdom; 4 Medical Physics, University of<br />

Edinburgh, Edinburgh, United Kingdom<br />

Intensity of white matter lesions (WMLs) on structural MRI may be linked to the severity of underlying white matter damage, and hence to old age cognitive<br />

decline. Here we investigate relationships between the volumes of intense (i) and less-intense (Li) WMLs in a unique cohort of ? subjects in whom cognitive<br />

ability is available in both youth (11 years) and old age (72-73 years). iWMLs were predominant located in frontal areas, while LiWMLs were mainly<br />

located posteriorly. iWMLs had a stronger relationship with cognition than LiWMLs in both youth and old age. These findings support the frontal ageing<br />

hypothesis.<br />

2002. Investigation of Cerebral Ischemic Disease in the Aged with Aortic Stenosis<br />

Ping Wang 1 , Elizabeth Strambrook 2 , Michel Bilello 1 , Thomas Floyd 3<br />

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 Anesthesiology & Critical Care, University of<br />

Pennsylvania, Philadelphia, PA, United States; 3 Anesthesiology & Critical Care, and Neurology, University of Pennsylvania,<br />

Philadelphia, PA, United States<br />

To test the correlations of aging, sex, and aortic stenosis (AS) degree with the severity of pre-existing white matter and ischemia-like lesions. Aging was<br />

associated with rapidly progressive cerebral ischemic disease; female sex accounted for a 56% increased in lesion volume over men; while the severity of<br />

AS did not demonstrate statistical significance in influencing lesion volume, univariate analysis demonstrated an important trend of increasing lesion volume<br />

with increasing severity of AS.<br />

2003. Novel Atlas-Based Technique for Longitudinal Investigation of Diffusion Tensor Tractography Data:<br />

Application to Healthy Ageing<br />

Ai Wern Chung 1 , Rebecca A. Charlton 1 , Nigel C. Lawes 2 , Robin G. Morris 3 , Hugh S. Markus 1 , Thomas R.<br />

Barrick 1<br />

1 Centre for Clinical Neuroscience, Saint George's University of London, London, United Kingdom; 2 Graduate Medical School,<br />

University of Limerick, Limerick, Ireland; 3 Department of Psychology, Institute of Psychiatry, King's College University of London,<br />

London, United Kingdom<br />

We present a novel technique applying probabilistic diffusion tensor tractography on longitudinal data to assess white matter structural integrity in ageing<br />

subjects over a period of two years. Our method was able to consistently extract white matter tracts associated with working memory over time and between<br />

two ageing cohorts (middle-aged and elderly). Tract connections were found between the fronto-temporal, fronto-parietal and temporo-parietal lobes. Our<br />

study suggests a decrease in white matter structural integrity of these tracts with age could be related to the decline in working memory performance.

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