TRADITIONAL POSTER - ismrm

Poster Sessions
2111. Chronic Cerebrospinal Venous Insufficiency and Iron Deposition on Susceptibility-Weighted Imaging
in Patients with Multiple Sclerosis
Robert Zivadinov 1 , Paolo Zamboni 2 , E. Mark Haacke 3 , Erica Menegatti 4 , Bianca Weinstock-Guttman 5 ,
Claudiu Schirda 1 , Anna M. Malagoni 2 , David Hojnacki 5 , Cheryl Kennedy 1 , Ellen Carl 1 , Niels Bergsland 1 ,
Sara Hussein 1 , Mari Heininen-Brown 1 , Ilaria Bartolomei 6 , Fabrizio Salvi 2 , Michael G. Dwyer 1
1 University at Buffalo, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; 2 University of Ferrera- Bellaria
Neurosciences, Vascular Diseases Center, Ferrera, Italy; 3 MR Research Facility, Wayne State University, Detroit, MI, United States;
4 University of Ferrera- Bellaria Neurosciences, Vascular Diseases Center, Buffalo, NY, United States; 5 University at Buffalo, The
Jacobs Neurological Institute, Buffalo, NY, United States; 6 University of Ferrera- Bellaria Neurosciences, Vascular Diseases Center,
Ferrera, NY, United States
Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular picture in multiple sclerosis patients characterized by stenoses affecting the main
extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. We explored
relationship between venous hemodynamic (VH) parameters and disability and iron concentration in deep-gray matter (DGM) structures and lesions on
susceptibility-weighted imaging. There was a significant association between higher number of VH criteria and higher iron concentration in T2 and T1
lesion volumes. Higher iron concentration in DGM structures was strongly associated with higher disability status.
2112. Cine Cerebrospinal Fluid Imaging in Multiple Sclerosis. a Case-Control Study
Robert Zivadinov 1 , Christopher Magnano 2 , Bianca Weinstock-Guttman 3 , David Wack 2 , Eric Lindzen 3 ,
David Hojnacki 3 , Niels Bergsland 2 , Cheryl Kennedy 2 , Justine Reuther 2 , Michael G. Dwyer 2 , Claudiu
Schirda 2
1 Neurology, Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States; 2 University at Buffalo, Buffalo Neuroimaging
Analysis Center, Buffalo, NY, United States; 3 University at Buffalo, The Jacobs Neurological Institute, Buffalo, NY, United States
To investigate the cerebrospinal fluid (CSF) dynamics in Sylvius aqueduct in multiple sclerosis (MS) patients versus healthy controls (HC) and to define
correlates with other specific disease metrics.
2113. An Objective Quantification Technique of the Cerebrospinal Fluid (CSF) Flow in the Cerebral
Aqueduct, in Patients with Multiple Sclerosis
Claudiu Schirda 1 , Paolo Zamboni 2 , Christopher Magnano 1 , Eric Lindzen 3 , David Wack 1 , Bianca
Weinstock-Guttman 3 , Deepa Ramasamy 1 , Ellen Carl 1 , David Hojnacki 3 , Cheryl Kennedy 1 , Michael Dwyer 1 ,
Niels Bergsland 1 , Jennifer Cox 1 , Fabrizio Salvi 2 , Robert Zivadinov 1,3
1 Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, United States; 2 University of Ferrara, Ferrara, Italy; 3 The
Jacobs Neurological Institute, University at Buffalo, Buffalo, NY, United States
When compared to white matter or gray matter, the involvement of the cerebrospinal fluid (CSF) in the Multiple Sclerosis (MS) disease has scarcely been
explored until now and typically a lumbar puncture is required. We investigate the flow properties of the CSF in the aqueduct of Sylvius and how they relate
to other MS disease metrics, by using non-invasive MRI in a pilot study with MS patients and healthy controls. An objective flow quantification technique
using automatic segmentation of the aqueduct was developed and was validated on a flow phantom and scan-rescanning 4 subjects within a week.
2114. Effects of Temporal Resolution on Blood-Brain Barrier Permeability Measurement with Dynamic
Contrast Enhanced MRI in Multiple Sclerosis Enhancing Lesions
Ileana Ozana Jelescu 1 , Ilana Ruth Leppert 1 , Sridar Narayanan 1 , Douglas L. Arnold 1 , G Bruce Pike 1
1 Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Accurate and reproducible measurements of blood-brain barrier permeability in MS enhancing lesions would benefit follow-ups of lesion activity and
comparison of detection sensitivity between different Gd-enhanced protocols. We propose a Dynamic Contrast Enhanced MRI protocol that allows sampling
of the arterial input function with high temporal resolution in the first minute post-injection, followed by a lower temporal resolution but high spatial
resolution acquisition of enhancement in lesions. This “dual temporal resolution” method was tested experimentally and through simulations and, compared
to previous methods, has proven to yield more accurate and precise estimates over a wide range of permeability values.
2115. Relative Recirculation (RR): A Potential Tool for Monitoring Blood-Brain Barrier Disruption in
Secondary Progressive Multiple Sclerosis
Andrea Kassner 1,2 , Igor Sitartchouk 1 , Rebecca E. Thornhill 1,2 , Timothy J. Carroll 3 , Chaitali Mulay 4 ,
Richard Aviv 1,4
1 Medical Imaging, University of Toronto, Toronto, Ontario, Canada; 2 Physiology and Experimental Medicine, Hospital for Sick
Children, Toronto, Ontario, Canada; 3 Radiology, Northwestern University, Chicago, IL, United States; 4 Neuroradiology, Sunnybrook
Health Sciences Centre, Toronto, Ontario, Canada
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. While blood-brain barrier (BBB) disruption associated with
relapsing-remitting MS is readily identified using gadolinium-enhanced T1-weighted MRI, these MRI markers lack the sensitivity required for monitoring
secondary progressive MS. Relative recirculation (rR), a parameter extracted from dynamic susceptibility contrast (DSC) data, can delineate BBB disruption
in patients with acute ischemic stroke. Relative recirculation was measured from DSC perfusion data obtained from 19 patients with secondary progressive
MS. The average lesion rR was significantly greater than in normal appearing white matter and shows potential for monitoring secondary progressive MS.