TRADITIONAL POSTER - ismrm

Poster Sessions
2044. Young Adults Born with Very Low Birth Weight Demonstrate Widespread White Matter
Abnormalities on Brain DTI
Live Eikenes 1 , Jon Skranes 2 , Ann-Mari Brubakk 2 , Asta Håberg 3
1 Department of circulation and medical imaging, Norwegian University of Science and Technology, Trondheim, Norway;
2 Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim,
Norway; 3 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
Preterm birth with very low birth weight (VLBW, ≤ 1500 g) is associated with reduced white matter integrity and connectivity in childhood and adolescence.
These changes in white matter are correlated to motor, sensory and neuropsychological impairments. This study demonstrates that preterm birth with VLBW
results in significant and long-term irreversible changes in white matter microstructure that may interfere with neuropsychological functioning. Lower birth
weight and perinatal problems requiring prolonged treatment on mechanical ventilator and/or intensive care have permanent negative effects on white matter
integrity.
2045. Fractional Anisotropy Correlates with Total IQ and Visual Perception in Young Adults Born with
Very Low Birth Weight
Live Eikenes 1 , Gro Løhaugen 2 , Kjerstin Bjørlykke 2 , Ann-Mari Brubakk 2 , Jon Skranes 2 , Asta Håberg 3
1 Department of circulation and medical imaging, Norwegian University of Science and Technology, Trondheim, Norway;
2 Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim,
Norway; 3 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
Perinatal brain injury caused by very preterm birth with very low birth weight (VLBW, ≤ 1500 g) is associated with changes in white matter integrity and
connectivity, and to a variety of neurodevelopmental problems including cognitive impairments and visual perceptual deficits in childhood and adolescence.
Widespread correlations between fractional anisotropy and total IQ and visual perception scores was detected in a young adult VLBW group, demonstrating
the pervasive nature of the reduction in cognition and perception in this group. The results demonstrate that the neuroimpairments persist into adulthood.
2046. The Rate of Reduction in Cerebral Cortical Diffusion Anisotropy Reflects the Rate of Brain
Development
Lindsey A. Leigland 1 , Christopher D. Kroenke 1
1 Oregon Health & Science University, Portland, OR, United States
Throughout the human gestational period, morphological differentiation of cortical neurons and glial cells cause water diffusion anisotropy within the
developing cerebral cortex to decrease with age. Herein, the loss of cortical fractional anisotropy (FA) reported by several research groups in five different
species is referenced against a systematic comparative study of the timing of several milestones in brain development. It is found that, when the loss of
cortical FA is approximated as an exponential decay with age, the time constant reflecting the rate of FA change is in agreement with independent estimates
of the rate in which developmental events occur.
2047. MRI Characterization of Cleft Lip and Palate Resulting from Hedgehog Signaling Antagonism in Mice
Rob Lipinski 1 , Chihwa Song 2 , Jerry Gipp 3 , Wade Bushman 3 , Ian Rowland 4
1 Bowles Center for Alcohol Research, University of North Carolina, Chapel Hill, NC, United States; 2 Medical Physics, University of
Wisconsin, Madison, WI, United States; 3 Urology Department, University of Wisconsin, Madison, WI, United States; 4 Department of
Radiology, University of Wisconsin, Madison, WI, United States
In utero Hedgehog (Hh) signaling antagonist exposure causes a spectrum of birth defects including holoprosencephaly (HPE) and cleft lip and palate (CLP).
High resolution MRI and standard histological methodologies were used to characterize the CNS phenotype of GD16.5 mouse fetuses exposed to Hh
antagonists. HPE fetuses exhibited incompletely separated cerebral hemispheres and complete pituitary and olfactory bulb agenesis. Those with CLP
exhibited olfactory bulb hypoplasia and anterior pituitary aplasia. These results demonstrate phenotypic fidelity of the mouse model to known clinical
phenotypes and highlight subtle CNS abnormalities as are expected to occur in a subset of clinical CLP populations.
2048. Impaired Neurodevelopmental Outcome Associated with Increased White Matter Chol/Cr in Preterm
Infants
David Price 1 , Giles Simon Kendall 2 , Alan Bainbridge 1 , Samantha Johnson 2 , Cornelia Hagmann 2 , Roxanna
Gunny 3 , Xavier Golay 4 , Ernest B. Cady 1 , Nicola Jane Robertson 2 , Enrico De Vita 5
1 Medical Physics & Bio-Engineering, UCL Hospitals NHS Foundation Trust, London, United Kingdom; 2 Academic Neonatology,
EGA UCL Institute for Women's Health, London, United Kingdom; 3 Neuroradiology, Great Ormond Street Hospital for Children;
4 Institute of Neurology, University College London; 5 Lysholm Department of Neuroradiology, UCL Hospitals NHS Foundation Trust,
London, United Kingdom
Infants born prematurely have a higher incidence of neurodevelopmental disorders. Diffuse white matter injury is the commonest MR finding in preterm
infants, and has been described qualitatively and quantitatively; the clinical correlate of diffuse white matter injury is currently unknown. In the current
study raised Cho/Cr and Lac/Cr, and reduced Naa/Cho were significantly associated with composite motor outcome at 12 months corrected age, and
accounted for by significant associations with gross motor development. The raised choline could be attributed to delayed myelination, astrogliosis; the
raised Lac/Cr suggests impaired oxidative phosphorylation, and the reduced Naa is in keeping with neuronal loss.