TRADITIONAL POSTER - ismrm

Poster Sessions
1258. VCAM-1 Targeted MRI for Imaging of Inflammation in Mouse Atherosclerosis Using Paramagnetic
and Superparamagnetic Lipid-Based Contrast Agents
Glenda Sibylle van Bochove 1 , Martijn L. Chatrou 1 , Leonie E. Paulis 1 , Holger Grüll 1,2 , Gustav J. Strijkers 1 ,
Klaas Nicolay 1
1 Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2 Bio-Molecular Engineering, Philips
Research Europe, Eindhoven, Netherlands
The purpose of this study was to image VCAM-1 expression in carotid artery lesions of apoE-/- mice, to compare the efficacy of a lipid-based paramagnetic
and a lipid-based superparamagnetic contrast agent, and to relate contrast changes to plaque location. Paramagnetic liposomes and superparamagnetic
micellar iron oxides targeted to VCAM-1 were prepared. Both contrast agents showed strong and specific accumulation in VCAM-1 over-expressing cells in
vitro. In vivo targeting to mouse carotid artery atherosclerotic plaques was demonstrated. Contrast changes were most pronounced in the plaque shoulders,
which are known to be most active in inflammatory cell recruitment.
1259. Association Between Carotid Artery and Thoracic Aorta Plaque Burden in Patients with
Neurovascular Symptoms: A 3.0T, Multiple Vascular Beds, Black-Blood Vessel Wall Imaging Study
Xihai Zhao 1 , Huilin Zhao 2 , Ye Cao 2 , Jinnan Wang 3 , Niranjan Balu 1 , Jianrong Xu 2 , Chuan Yuan 1
1 Radiology, University of Washington, Seattle, WA, United States; 2 Radiology, Shanghai Renji hospital, Shanghai Jiaotong
University, Shanghai, China; 3 3. Philips Research North America, Briarcliff Manor, NY, United States
Atherosclerosis is a systemic disease frequently involving multiple vascular territories, such as carotid artery and thoracic aorta, which are related to
cerebrovascular events. Thus, atherosclerotic disease in one vascular bed may be an indicator for the other vasculatures. This study sought to determine the
association between carotid artery and thoracic aorta atherosclerosis using MR black-blood vessel wall imaging in 26 symptomatic patients. We found that
carotid artery plaque burden, particularly on left side, was significantly associated with that of descending aorta. Our findings suggest that atherosclerotic
disease in carotid artery may be an indicator of thoracic atheroma, or vice versa.
1260. Accelerating 3D Molecular MR Imaging Using Compressed Sensing
Claudia Prieto 1 , Marcelo Andia 1 , Tobias Schaeffter 1 , Rene M. Botnar 1
1 Division of Imaging Sciences, King's College London, London, United Kingdom
Accelerated Molecular MR-imaging using Compressed Sensing (CS) is demonstrated for preclinical applications. The sparsity requirement of CS is satisfied
in most molecular MR-images, due to the high localized T1-contrast enhancement produced by target-specific contrast agents. Good overall image quality
was achieved with acceleration factors up to 4 in 3D preclinical studies of venous thromboembolism and aortic vessel wall. CS is especially useful for small
animal studies (requiring high spatial resolution and thus suffering from prolonged scan times), whereas other acceleration techniques such as parallel
imaging often cannot be applied due to the limited availability of multi channel small animal coils.
1261. Anti-Angiotensin Drug Evaluation in ApoE-/- Mice by USPIO-Enhanced MRI at 7T
Olivia Monica Sigovan 1 , Amine Bessaad 1 , Elena Kaye 2 , Eric Lancelot 3 , Claire Corot 3 , Nicolas Provost 4 ,
Zouher Majd 4 , Magali Breisse 4 , Emmanuelle Canet-Soulas 1
1 CREATIS-LRMN Laboratory, Lyon1 University, Lyon, France; 2 Radiology, Stanford University, United States; 3 Guerbet Group,
Paris, France; 4 Genfit, Lille, France
Irbesartan (SR 47436) is an orally active nonpeptide Angiotensin II type 1 (AT1) receptor antagonist. We report here an USPIO-enhanced MRI follow-up
study performed on apolipoprotein (apo) E-deficient mice with the goal of following Irbesartan’s therapeutic effect on the development and progression of
atherosclerotic lesions. Irbesartan lead to a marked reduction in the plaque formation. Post USPIO T2* values measured in the vessel wall showed significant
decrease compared to baseline values, however no differences were found between treated and not treated groups. The obtained information (from the
ascending aorta) may not be representative of the general effect of the drug.
1262. DCE-MRI for the Evaluation of Atherosclerosis in Patients with Exposure to Particulate Matter
Venkatesh Mani 1 , Simonette T. Sawit 2 , Claudia Calcagno 1 , Cynara Maceda 2 , Colin Moncrieff 1 , Zahi Adel
Fayad 1 , Jacqueline Moline 3 , MaryAnn McLaughlin 2
1 Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2 Cardiology, Mount Sinai School of Medicine, New
York, NY, United States; 3 Preventive Medicine, Mount Sinai School of Medicine, New York, NY, United States
Exposure to particulate matter (PM) has been associated with adverse health effects leading to increased morbidity and mortality. Dynamic contrast
enhanced (DCE) MRI and peripheral arterial tonometry (PAT) may potentially be used to evaluate differences in atherosclerosis in patients with high and
low PM exposure. There was correlation between DCE-MRI measures and endothelial function measured by PAT. Despite NO significant differences
between groups in patient characteristics, and vessel wall morphometrics, high exposure group had significantly lower DCE MRI measures. We conclude
that DCE-MRI may be used to evaluate differences in atherosclerosis due to different levels of PM exposure.
1263. In Vivo Carotid Plaque Magnetic Resonance Imaging Using Quantitative T 2 * Measurments with
USPIO Particles: A Dose-Response Study to Statin Therapy
Andrew James Patterson 1 , Tjun Y. Tang 1 , Martin J. Graves 1 , Simon P. S. Howarth 1 , Jonathan H. Gillard 1
1 Radiology, University of Cambridge, Cambridge, England, United Kingdom
Previous studies have reported Ultra-Small Super-Paramagnetic Iron Oxide (USPIO) detected inflammation in carotid atherosclerotic disease using a semiquantitative
analysis technique that involves measuring changes in signal intensity relative to adjacent muscle tissue. In this study an alternative method to
detect and quantify changes over-time is presented. The methodology involved making direct quantitative T 2 * measurements within the atherosclerotic
plaque pre- and post- infusion. In a double blinded randomised control trail this study measured a significant difference (p