TRADITIONAL POSTER - ismrm

Poster Sessions
2095. Evidence of Subcortical Grey Matter Atrophy and Surface Morphology Differences in Primary
Progressive Multiple Sclerosis
Rose Gelineau-Kattner 1,2 , Tarunya Arun 1 , Damian Jenkins 1 , Morgan Hough 1 , Jacqueline Palace 3 , Mark
Jenkinson 1
1 FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2 Baylor College of Medicine, Houston, TX, United States; 3 Clinical
Neurology, Oxford University and Oxford Radcliffe Hospitals NHS Trust, United Kingdom
Grey matter damage is important in the pathology of Primary Progressive Multiple Sclerosis (PPMS). We scanned 22 patients and 7 controls at baseline,
and 2, 50, and 52 weeks. FreeSurfer was used to segment subcortical grey matter and vertex analysis was performed with FSL’s FIRST to identify
differences in surface morphology between groups. Significant atrophy and correlations with EDSS and/or disease duration were seen in some structures at
baseline and all structures showed volume reduction over one year. Surface morphology differences were found in the thalamus and pallidum. Results
highlight importance of subcortical atrophy and structural morphology differences in PPMS.
2096. Regional Gray Matter Volumes Changes in Relapsing-Remitting and Secondary Progressive Multiple
Sclerosis – a Longitudinal Comparative Voxel-Based Morphometry Study
Kerstin Bendfeldt 1 , Louis Hofstetter, Pascal Kuster, Stefan Traud, Nicole Müller-Lenke, Yvonne Naegelin,
Ludwig Kappos, Achim Gass, Thomas E. Nichols 2 , Frederik Barkhof 3 , Stephan Roosendaal 3 , Jeroen
Geurts 3 , Hugo Vrenken 3 , Ernst-Wilhelm Radue, Stefan J. Borgwardt 4
1 University Hospital Basel, Basel, Basel-Stadt, Switzerland; 2 University of Warwick; 3 University of Amsterdam; 4 Medical Image
Analysis Centre, University Hospital Basel, Basel, Basel-Stadt, Switzerland
We used optimized voxel-based morphometry to study similarities and differences of regional gray matter volume development in relapsing remitting and
secondary progressive MS. Although regional gray matter volume measures reveal areas of significant gray matter volume loss in RRMS, the results from
this study suggest, that there is no marked acceleration in the progressive phase of the disease. This implies that the more pronounced impact of gray matter
pathology in the secondary progressive phase is a result of longer linear accrual of such damage, rather than a phase-specific acceleration.
2097. Gender Effects on Atrophy in MS: Cognitive Implications
Menno M. Schoonheim 1 , Doriana Landi 2 , Jeroen JG Geurts 1,3 , Hugo Vrenken 1,4 , Ernesto J. Sanz-Arigita 1 ,
Linda Douw 5 , Chris H. Polman 5 , Frederik Barkhof 1
1 Radiology, VU University Medical Center, Amsterdam, Noord Holland, Netherlands; 2 Università Campus Biomedico, Rome, Italy;
3 Pathology, VU University Medical Center, Amsterdam, Noord Holland, Netherlands; 4 Physics & Medical Technology, VU
University Medical Center, Amsterdam, Noord Holland, Netherlands; 5 Neurology, VU University Medical Center, Amsterdam, Noord
Holland, Netherlands
Multiple sclerosis displays clear gender effects in female predisposition, as well as male negative clinical prognosis. To investigate gender effects of atrophy
and cognition in MS, we acquired brain volumes and neuropsychological assessments in 32 RRMS patients (14 male, 17 female) and 22 healthy controls (10
male, 12 female). Atrophy and cognitive impairment were present in male patients only. An interaction between group and gender was present for wholebrain
volume and verbal memory. These were correlated in the patient group only. This underlines the need for future research to investigate gender effects
in MS more thoroughly, with possible therapeutic implications.
2098. Memory Impairment in MS Correlates to Hemodynamic Response in Event-Related FMRI of Episodic
Memory
Katherine A. Koenig 1 , Blessy Mathew 1 , Jian Lin 1 , Lael Stone 2 , Stephen Rao 3 , Michael Phillips 1 , Mark J.
Lowe 1
1 Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2 Mellen Center, The Cleveland Clinic, Cleveland, OH, United
States; 3 Schey Center, The Cleveland Clinic, Cleveland, OH, United States
Nineteen patients with MS performed a verbal incidental encoding task, followed by a word recognition task (WR). Stimuli from the WR task were split into
“encoded” and “non-encoded” based on performance of each subject. The encoded stimuli of the five highest performers were used to create an average t-
map to select regions of interest for a correlation analysis. Areas involved in semantic encoding, including the DLPFC and the inferior frontal gyrus, showed
a significant positive correlation between the fit hemodynamic response amplitude during encoded stimuli on the WR task and a test of verbal memory.
2099. Corpus Callosum Fractional Anisotropy Predicts Clinical Progression and Cognitive Dysfunction in
Early Primary-Progressive MS: A 5 Year Follow-Up Study
Benedetta Bodini 1 , Mara Cercignani 2 , Zhaleh Khaleeli 1 , Sophie Penny 3,4 , Maria Ron 5 , David H. Miller 5 ,
Alan J. Thompson 1 , Olga Ciccarelli 1
1 NMR Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 2 Neuroimaging
Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; 3 NMR Unit, Department of Neuroinflammation, UCL Institute of
Neurology , London, United Kingdom; 4 Department of Psychology, National Hospital for Neurology and Neurosurgery, London,
United Kingdom; 5 NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
The aim of this study was to identify which brain area predicts the development of disability over five years and cognitive dysfunction after five years in 32
patients with early primary-progressive multiple sclerosis. Employing tract-based spatial statistics and voxel-based morphometry, we found that lower
fractional anisotropy in the corpus callosum at study entry predicted a greater progression of disability, as measured by the EDSS, over the follow-up, and
worse verbal memory, attention and speed of information processing, and executive functions, after five years. Our findings highlight the importance of
damage to the inter-hemispheric callosal pathways in determining disability in MS.