Labelling Review row-Online

Acutely infected human liver: immunohistochemical staining for Hepatitis C virus (HCV) nonstructural
protein 3 using NCL-HCV-NS3. Note cytoplasmic staining of HCV-infected
hepatocytes. Paraffin section.
Hepatocyte Growth Factor Receptor
(c-MET)
Clone 8F11
1 mL, 0.1 mL lyophilized NCL-cMET F P (HIER)
See also c-MET (Hepatocyte Growth Factor Receptor) on page 92.
Hepatocyte Specific Antigen
Clone OCH1E5
1 mL, 0.1 mL lyophilized NCL-HSA P
Hepatoblastoma is reported to be the most common primary tumor of the
liver in children. The distinction of hepatoblastoma, especially the
embryonal type, from other small round cell tumors of childhood can sometimes
be difficult. It is reported that the detection of specific hepatocyte
antigens, alpha fetoprotein or carcinoembryonic antigen are expressed in
normal and malignant fetal hepatocytes.
Product Specific Information
NCL-HSA recognizes an uncharacterized antigen present in both adult and
fetal normal hepatocytes to produce a distinct granular cytoplasmic staining.
Human liver, hepatitis B positive: immunohistochemical staining for hepatocyte specific
antigen using NCL-HSA. Note granular cytoplasmic staining in a proportion of hepatocytes.
Paraffin section.
HER-2 (c-erbB-2 Oncoprotein)
Antibodies
Clone 5A2
1 mL lyophilized HER-2 (internal domain)
NCL-c-erbB-2-316 FP
Clone CB11
1 mL, 0.1 mL lyophilized HER-2 (internal domain)
NCL-CB11 FPC
1 mL liquid HER-2 (internal domain)
NCL-L-CB11 FPC
Reference Range
7 mL ready-to-use HER-2 (internal domain) RTU-CB11 FP
60 Tests Oracle HER2 Bond IHC System TA9145
Clone 10A7
1 mL, 0.1 mL lyophilized HER-2 (external domain)
NCL-CBE-356 PW
1 mL liquid HER-2 (external domain) NCL-L-CBE-356 PW
7 mL ready-to-use HER-2 (external domain) RTU-CBE-356 P
Clone CBE1
1 mL, 0.1 mL lyophilized HER-2 (external domain)
NCL-CBE1 F P (HIER)
Polyclonal
0.2 mL lyophilized HER-2 (internal domain) NCL-PC11 FP
The c-erbB-2 oncoprotein is closely-related in structure to the epidermal
growth factor receptor and is a member of a large family of cell surface
growth factor receptors. c-erbB-2 oncoprotein is reported to be detectable
in a proportion of breast and other adenocarcinomas as well as transitional
cell carcinomas. c-erbB-2 oncoprotein is present in a wide variety of cell
types in a range of normal human fetal and adult tissues, including breast,
stomach and ovary.
Product Specific Information
NCL-c-erbB-2-316, NCL-CB11, NCL-L-CB11, NCL-PC11 and RTU-CB11 all
detect the internal domain of the c-erbB-2 oncoprotein. NCL-CBE-356,
NCL-L-CBE-356, NCL-CBE1 and RTU-CBE-356 detect the external domain of
the c-erbB-2 oncoprotein. NCL-CB11 is effective with no pretreatment on
fixed, paraffin-embedded tissue but the use of the heat induced epitope
retrieval (HIER) technique may enhance staining in some cases. To obtain
optimal staining on frozen tissue, Carnoy's fixative is recommended.
For more information on the Oracle HER2 Bond IHC System see page 11.
Human breast carcinoma: immunohistochemical staining for c-erbB-2 oncoprotein using
NCL-CBE-356. Note intense membrane staining of tumor cells. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Primary Antibodies