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Primary Antibodies
CD117 (c-kit Oncoprotein)
Clone T595
1 mL lyophilized NCL-CD117 P (HIER)
1 mL liquid NCL-L-CD117 P (HIER)
7 mL ready-to-use RTU-CD117 P (HIER)
Clone 57A5D8
1 mL lyophilized NCL-cKIT F
See also c-kit Oncoprotein (CD117) on page 91.
CD123
Clone BR4MS New!
1 mL, 0.1 mL liquid NCL-L-CD123 P (HIER)
The CD123 antigen is also known as the alpha subunit of the human
interleukin-3 receptor. It is a type I transmembrane glycoprotein and is a
member of the cytokine receptor superfamily. CD123 forms a heterodimer
with CD131 (the beta subunit of the interleukin-3 receptor) to form the
interleukin-3 receptor, where the cytokine specificity is provided by the
alpha subunit and the signal transduction function is provided by the beta
subunit. The interleukin-3 receptor is reported to be expressed on
monocytes, neutrophils, basophils, eosinophils, megakaryocytes,
proliferation and differentiation of these cells. Outside the hematopoietic
system CD123 is reported to be expressed in Leydig cells of the testis, some
endothelial cells, and cells of the placenta and brain.
Human high venule endothelium and plasmacytoid dendritic cells: immunohistochemical
staining for CD123 using NCL-L-CD123. Paraffin section.
CD134 (OX40)
Clone 102H6
1 mL lyophilized NCL-CD134 F P (HIER)
The CD134 molecule is a member of the tumor necrosis factor receptor
superfamily. It was originally named MRC OX40 after the first antibody which
led to its discovery. CD134 protein binds to OX40 ligand and is expressed
specifically on activated T lymphocytes with maximum expression determined
at twenty four hours post stimulus. In rats, CD134 protein is only
expressed on activated CD4 positive T lymphocytes and in humans it is
described as being found predominantly on CD4 positive cells. In mice,
CD134 protein is expressed on both activated CD4 positive and CD4 positive/
CD8 positive cells. The OX40 ligand binds CD134 protein on T cells and costimulates
proliferation. Crosslinking of CD134 with OX40 ligand on activated
B cells stimulates proliferation and antibody production suggesting a role in
B cell differentiation into plasma cells. Functionally, the CD134 molecule is
involved in T cell co-stimulation and T cell dependent antibody production.
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Human tonsil: immunohistochemical staining for CD134 antigen using NCL-CD134. Note intense
membrane staining of activated T lymphocytes. Paraffin section.
CD137
Clone S16
1 mL lyophilized NCL-CD137 P (HIER)
CD137 antigen, a member of the tumor necrosis factor receptor family, and
its ligand are reported to be expressed on activated T lymphocytes and on
antigen-presenting cells, respectively. This receptor/ligand system
regulates the activation, proliferation and survival of T and B lymphocytes
and monocytes through bidirectional signal transduction. Human CD137
antigen is reported to be expressed on activated B cells, Reed Sternberg
cells and peripheral blood monocytes but is absent from resting T cells. In
nonlymphoid cells, expression has been reported in blood vessel walls, on
the endothelial layer and on vascular smooth muscle cells. Soluble forms of
CD137 are reported at increased levels in sera of individuals with
rheumatoid arthritis. The expression of soluble CD137 lags behind that of
membrane bound CD137 by approximately 24 hours and it has been
proposed that as activation of lymphocytes through membrane-bound CD137
delivers a potent stimulatory signal then soluble CD137 may provide a
negative control mechanism for immune responses.
Human tonsil: immunohistochemical staining for CD137 antigen using NCL-CD137. Note intense
membrane staining of activated lymphoid cells. Paraffin section.
CD141 (Thrombomodulin)
Clone 15C8
1 mL, 0.1 mL lyophilized NCL-CD141 F P (HIER)
See also Thrombomodulin (CD141) on page 162.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.