Labelling Review row-Online

Ki67
Clone MM1
50 Tests ORG-8772 IVD
Ki67 is a nuclear cell cycle associated protein, which is expressed in all
active parts of the cell cycle (G1, S, G2 and mitosis) but not in resting cells
(G0). In contrast to many other cell cycle associated proteins the Ki67
antigen is consistently absent in quiescent cells and is not detectable during
DNA repair processes. Thus, the presence of Ki67 is strictly associated with
the cell cycle and confined to the nucleus.
Product Specific Information
Origin Ki67 (Clone MM1) can be utilized in the assessment of cell proliferation
in normal and neoplastic tissues.
Refer to page 126 for further information about Clone MM1.
Origin Ki67 (Clone MM1) on breast carcinoma. Paraffin section.
Melan A
Clone A103
50 Tests ORG-8953 IVD
Melan A, a product of the MART-1 gene, is a melanocyte differentiation
marker recognized by autologous cytotoxic T lymphocytes. Other
melanoma-associated markers recognized by autologous cytotoxic T cells
are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1
and GAGE-1. The analysis of these different molecules and their expression
in individual melanomas may be of help in the study of their particular roles
in tumorigenesis.
Product Specific Information
Origin Melan A (Clone A103) is recommended for the assessment of Melan A
in melanocytic lesions.
Refer to page 132 for further information about Clone a103.
Origin Melan A (Clone A103) on malignant melanoma. Paraffin section.
Melanosome
Clone HMB45
50 Tests ORG-8854 IVD
The melanosome antigen has been identified in retinal pigment epithelium
(RPE) but is reported to be reactive only with transient prenatal and infantile
RPE. Tumor cells of epithelial lymphoid, glial and mesenchymal origin are
reported to be negative.
Product Specific Information
Origin Melanosome (Clone HMB45) is recommended for use as part of a panel
of antibodies for the diagnosis of melanoma.
Refer to page 120 for further information about Clone HMB45.
Origin Melanosome (Clone HMB45) on malignant melanoma. Paraffin section.
Progesterone Receptor
Clone 16
50 Tests ORG-8721 IVD
The human progesterone receptor (PR) is expressed as two isoforms, PRA
(94 kD) and PRB (114 kD), which function as ligand-activated transcription
factors. The PRA form is a truncated version of the PRB form, lacking the
first 164 N-terminal amino acids. In humans, PRA activity acts as a
transdominant repressor of the transcriptional of PRB, glucocorticoid
receptor, ER, androgen receptor and mineralocorticoid receptor.
Product Specific Information
Origin Progesterone Receptor (Clone 16) binds specifically to the PRA antigen
in the nuclei of normal and neoplastic tissues, as such it is recommended for
determining the progesterone receptor alpha status of breast cancer tissue.
Refer to page 152 for further information about Clone 16.
Origin Progesterone Receptor (Clone 16) on breast carcinoma. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Origin