Labelling Review row-Online

Pax-5
Clone 1EW
7 mL Bond ready-to-use PA0552 P (HIER)
For In Vitro Diagnostic Use
Pax genes are a family of developmental control genes that encode nuclear
transcription factors and have been implicated in the control of mammalian
development.
PAX-5 is a B cell specific transcription factor, that is expressed in pro B
cells, pre-B, mature B cells and subsequently in all stages of B cell
development until the plasma cell stage in which it is downregulated.
Also available as a Novocastra concentrate, refer to page 148.
Lymphoma: immunohistochemical staining with Bond ready-to-use Pax-5 (1EW) using Bond
Polymer Refine Detection.
Placental Alkaline Phosphatase
Clone 8A9
7 mL Bond ready-to-use PA0161 P (HIER)
For In Vitro Diagnostic Use
Reports indicate that Clone 8A9 stains seminomas and placenta indicating a
specificity for both PLAP and PLAP-like enzyme. Placental alkaline phosphatase
(PLAP) is a membrane-associated sialoglycoprotein enzyme
normally present at high concentration in syncytiotrophoblasts within the
placenta during the third trimester of gestation. PLAP is reported to be
expressed only in normal term placenta, endocervix and fallopian tube and
also in ovarian and proximal gastrointestinal tumors. PLAP expression is
rare in malignant germ cell tumors. This is a distinct molecule from: A PLAPlike
variant has been described which shares more than 85 percent
homology with PLAP itself. PLAP-like enzyme is reported to be predominantly
found in normal fetal and neonatal testis, and in thymus. It is also
commonly expressed in germ cell tumors and more recently described in
seminomas. Used in the detection of seminomas.
Also available as a Novocastra concentrate, refer to page 150.
Seminoma: immunohistochemical staining with Bond ready-to-use Placental Alkaline
Phosphatase (8A9) using Bond Polymer Refine Detection.
Progesterone Receptor
Clone 16
7 mL Bond ready-to-use PA0312 P (HIER)
For In Vitro Diagnostic Use
Progesterone Receptor content in breast cancer is an important parameter in
the prediction of, prognosis and response to endocrine therapy. Progesterone
Receptor (16) is an aid in this management, prognosis and prediction of
therapy outcome.
Product Specific Information
Clone 16 is specific to the A form of progesterone receptor in formalin-fixed,
paraffin-embedded tissues.
Also available as a Novocastra concentrate, refer to page 152.
Breast carcinoma: immunohistochemical staining with Bond ready-to-use Progesterone
Receptor (16) using Bond Polymer Refine Detection.
Prostate Specific Antigen
Clone 35H9
7 mL Bond ready-to-use PA0431 P (HIER)
For In Vitro Diagnostic Use
Prostate specific antigen is a protein of the kallikrein family of protein
kinases. Distinct from Prostatic Acid Phosphatase, it has been found to be
immunologically identical and biologically similar to a protein isolated from
the prostate gland.
Also available as a Novocastra concentrate, refer to page 153.
Prostate: immunohistochemical staining with Bond ready-to-use Prostate Specific Antigen
(35H9) using Bond Polymer Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Bond