Labelling Review row-Online

Cytokeratin 8/18
Clone 5D3
7 mL Bond ready-to-use PA0067 P (HIER)
For In Vitro Diagnostic Use
In normal tissues, Cytokeratins 8 and 18 are reported to be expressed in all
simple and glandular epithelium. In neoplastic tissues they have been
shown to be expressed in adenocarcinomas and most squamous cell
carcinomas.
Product Specific Information
Cytokeratin 8/18 (5D3) is recommended for use as part of an antibody panel in
the identification of adenocarcinomas and most squamous cell carcinomas,
but keratinizing squamous carcinomas are generally negative.
Also available as a Novocastra concentrate, refer to page 99.
Colon mucosa: immunohistochemical staining with Bond ready-to-use Cytokeratin 8/18 (5D3)
using Bond Polymer Refine Detection.
Cytokeratin
(High Molecular Weight)
Clone 34�E12
7 mL Bond ready-to-use PA0134 P (Enzyme)
For In Vitro Diagnostic Use
Cytokeratin (High Molecular Weight) 34ßE12 reacts with human cytokeratin
intermediate filament proteins 1, 5, 10 and 14. Expression: squamous
epithelium and sweat ducts in normal skin, some pneumocytes, bronchial
epithelium and mesothelium in normal lung and bile ducts in normal liver.
Also ductal cells of the normal pancreas, some acinar and ductal cells of
normal breast, some follicular epithelia of normal thyroid and some epithelia
and mesothelium of the normal small and large bowel.
Also available as a Novocastra concentrate, refer to page 137.
Squamous cell carcinoma: immunohistochemical staining with Bond ready-to-use Cytokeratin
(High Molecular Weight) using Bond Polymer Refine Detection.
Cytokeratin Multi
Clone AE1 and AE3
7 mL Bond ready-to-use PA0909 P (Enzyme)
For In Vitro Diagnostic Use
Refer to page 34 for further information about Multi-Cytokeratin.
Desmin
Clone DE-R-11
7 mL Bond ready-to-use PA0032 P (HIER)
For In Vitro Diagnostic Use
Product Specific Information
Clone DE-R-11 reacts with the 18 kD rod region of the intermediate filament
protein desmin (53 kD) in both striated and smooth muscle cells. The labeling
is confined to the Z bands in cardiac and striated muscle giving a
characteristic striated staining pattern. It does not appear to react with any
other filament proteins.
Also available as a Novocastra concentrate, refer to page 101.
Leiomyosarcoma: immunohistochemical staining with Bond ready-to-use Desmin (DE-R-11)
using Bond Polymer Refine Detection.
DOG-1
Clone K9
7 mL Bond ready-to-use PA0219 P (HIER)
For In Vitro Diagnostic Use
Expressed on the plasma membrane of GIST (Gastro-Intestinal Stromal
Tumor), it is rarely expressed in other soft tissue tumors that can often be
confused with GISTs. DOG-1 (Discovered on GIST-1) immunoreactivity is
reported in 97.8 percent of scorable GISTs, including all KIT negative GISTs.
Also available as a Novocastra concentrate, refer to page 101.
Gastrointestinal stromal tumor: immunohistochemical staining with Bond ready-to-use DOG-1
(K9) using Bond Polymer Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Bond