Labelling Review row-Online

Primary Antibodies
Muramidase (Lysozyme)
Polyclonal
1 mL lyophilized NCL-MURAM P (Enzyme) W
7 mL Bond ready-to-use PA0391 P (HIER) New!
Intracellular muramidase, also known as lysozyme, has been reported to be
expressed in myeloid and monocytic cells, in leukocytes and in myeloproliferative
disorders. Muramidase is also reported to be expressed in
poorly differentiated leukemic monoblasts.
Refer to page 35 for the Bond ready-to-use format.
See also Lysozyme (Muramidase) on page 129.
Human spleen, myeloid leukemia: immunohistochemical staining for muramidase (lysozyme)
using NCL-MURAM. Note intense cytoplasmic staining of myeloid cells. Paraffin section.
Muscle Specific Actin
Clone SC28 New!
1 mL, 0.1 mL liquid NCL-L-MSA-594 PW
Clone HHF35
1 mL lyophilized NCL-MSA FPW
7 mL Bond ready-to-use PA0258 P
Muscle Specific Actin (MSA) is a highly conserved, ubiquitous protein found
in muscle and some non-muscle cells. Actins can be divided into three
subsets, alpha actins found in muscle tissue cells, beta and gamma actins
found in non-muscle cells and a small subset of gamma actins also found in
muscle tissue cells. In normal tissues, expression is found in striated fibers
of skeletal muscle, smooth muscle in arteries, veins and pericytes of smaller
arteries, muscle in bowel, myometrium of the uterus, prostatic stroma,
capsule cells of liver, kidney, lymph node and spleen, the myoepithelial
layers of mammary ducts and glands, eccrine sweat glands and salivary
glands. Expression is not found in epithelial cells, lymphoid cells,
macrophages, connective tissue and neuronal cells. In neoplastic tissues,
expression can be found in soft tissue tumors with muscle differentiation
e.g. leiomyomas, leiomyosarcomas and rhabdomyosarcomas of varying
subtypes.Non-muscle sarcomas, carcinomas, melanomas and lymphomas
do not express muscle specific actin.
Product Specific Information
NCL-L-MSA-594 was developed to outperform NCL-MSA in
immunohistochemistry.
Refer to page 35 for the Bond ready-to-use format.
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Human leiomyosarcoma: immunohistochemical staining for muscle specifi c actin using
NCL-L-MSA-594
Mycobacterium tuberculosis
Clone 1.1/3/1
1 mL lyophilized NCL-MT W
The re-emergence of tuberculosis itself, the significant increase in nontuberculous
mycobacterial infections in the immunosuppressed and the
changing epidemiology of childhood mycobacterial lymphadenitis make it
important to confirm the mycobacterial etiology of tissue granulomata
whenever possible.
Product Specific Information
NCL-MT is raised to the 38 kD antigen of the mycobacterium tuberculosis
complex (MTBC). NCL-MT reacts with several mycobacterial species, in
Western blotting, including Mycobacterium tuberculosis, other members of
the MTBC and Mycobacterium avium-intracellulare.
Myelin Basic Protein
Clone 7H11
1 mL, 0.1 mL lyophilized NCL-MBP P (HIER)
Myelin basic protein is reported to account for about 30 percent of the
proteins in myelin found in the central nervous system. It can induce
experimental allergic encephalomyelitis (EAE), a T-lymphocyte mediated
disease due to delayed-type hypersensitivity; though each animal species
appears to respond to a different fragment of the 170 amino acid
polypeptide. Four different isoforms have been identified through cDNA
cloning. All four of these variants are identical except for the insertion or
deletion of two peptide fragments encoded by exons 2 and 5. Myelin basic
protein is reported to be expressed in oligodendrocytes, myelin of white
matter in the brain and spinal cord and in peripheral nerves, though it is
expressed less abundantly in gray matter.
Product Specific Information
NCL-MBP was raised to guinea pig myelin basic protein and is reactive with
human myelin basic protein.
Human spinal cord, cervical: immunohistochemical staining for myelin basic protein using
NCL-MBP. Note cytoplasmic staining of cells in white matter. Paraffin section.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.