Labelling Review row-Online

Bond
Oct-2
Clone Oct-207
7 mL Bond ready-to-use PA0532 P (HIER)
For In Vitro Diagnostic Use
Oct-2 is a transcription factor belonging to the POU homeo-domain family
that binds to the Ig gene octamer sites regulating B cell specific genes. It is
dependent on the activity of B cell restricted coactivators such as BOB-1/
OBF-1. Reed Sternberg (RS) cells represent the malignant cells in classical
Hodgkin's disease and are derived from germinal center B cells. In a number
of these cases, cells do not express immunoglobulin due to the presence of
crippling mutations within the Ig genes. As Ig gene expression in B cells also
requires an interaction between octamer sites and the transactivating
factors Oct-2 and BOB.1, the absence of both Oct-2 and BOB-1 expression
represents a novel mechanism for immunoglobulin gene deregulation in RS
cells. Oct-2 protein expression is not restricted to B cells, although
expression levels are much higher in these cells. Germinal center B cells
show higher expression for Oct-2 and BOB-1/OBF-1. Oct-2 expression is
reported to be significantly greater in germinal center derived lymphomas,
although other B cell lymphomas also display high levels of expression.
Also available as a Novocastra concentrate, refer to page 143.
B cell lymphoma: immunohistochemical staining with Bond ready-to-use Oct-2 (Oct-207) using
Bond Polymer Refine Detection.
Oct 3/4
Clone N1NK New!
7 mL Bond ready-to-use PA0934 P (HIER)
For In Vitro Diagnostic Use
Oct3/4 is a member of the POU homeodomain family of transcription factors,
which is expressed by embryonic stem cells and germ cells. A critical
amount of Oct3/4 levels are associated with loss of pluripotency. Oct3/4 has
been proposed as a useful marker for germ cell tumors which exhibit
features of pluripotentiality, including seminoma/dysgerminoma and
embryonal carcinoma, and establishing a germ cell origin for some
metastatic tumors of uncertain primary tumor.
Also available as a Novocastra concentrate, refer to page 143.
Seminoma: immunohistochemical staining with Bond ready-to-use Oct-3/4 (N1NK) using Bond
Polymer Refine Detection.
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p53 Protein
Clone DO-7
7 mL Bond ready-to-use PA0057 P (HIER)
For In Vitro Diagnostic Use
p53 protein plays a vital role in suppressing the development of cancer. The
accumulation of p53 protein in response to DNA damage in vitro is well
established and appears to induce growth arrest and apoptosis by the
transcriptional regulation of other genes.
Product Specific Information
This monoclonal antibody recognizes both wild type and mutant forms of
human p53 protein. Bond ready-to-use p53 (DO7) is recommended for
determining the p53 status of a variety of carcinomas, including breast and
colorectal carcinomas.
Also available as a Novocastra concentrate, refer to page 145.
Bladder carcinoma: immunohistochemical staining with Bond ready-to-use p53 Protein (DO-7)
using Bond Polymer Refine Detection.
p63
Clone 7JUL
7 mL Bond ready-to-use PA0478 P (HIER)
For In Vitro Diagnostic Use
p63 is a type II integral membrane protein predominantly localized in the rough
endoplasmic reticulum. p63 is reported to be expressed in a number of normal
tissues including proliferating cells of the epithelium, cervix, urothelium and
prostate. p63 is reported to be expressed in most poorly differentiated
squamous cell carcinomas.
Also available as a Novocastra concentrate, refer to page 72.
Nasopharyngeal carcinoma: immunohistochemical staining with Bond ready-to-use p63 (7JUL)
using Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.