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Bond<br />

Terminal Deoxynucleotidyl Transferase<br />

Clone SEN28<br />

7 mL Bond ready-to-use PA0339 P (HIER)<br />

For In Vitro Diagnostic Use<br />

Terminal Deoxynucleotidyl Transferase (TdT) is a DNA polymerase. It is<br />

reported to be expressed in primitive T and B lymphocytes of the normal<br />

thymus and bone mar<strong>row</strong>. TdT is reported to be expressed in leukemias and<br />

acute lymphoblastic lymphomas where early and precise differentiation is<br />

crucial. The determination of TdT expression is reported to be most valuable<br />

when it is difficult to differentiate histologically between lymphoblastic<br />

lymphoma and Burkitt's lymphoma.<br />

Product Specific Information<br />

Terminal Deoxynucleotidyl Transferase (SEN28) is recommended for use in<br />

the diagnosis and differentiation of acute lymphoblastic leukemia/ lymphoma<br />

from other lymphomas.<br />

Also available as a Novocastra concentrate, refer to page 162.<br />

Thymus: immunohistochemical staining with Bond ready-to-use Terminal Deoxynucleotidyl<br />

Transferase (SEN28) using Bond Polymer Refine Detection.<br />

Thyroglobulin<br />

Clone 1D4<br />

7 mL Bond ready-to-use PA0025 P<br />

For In Vitro Diagnostic Use<br />

A heavily glycosylated protein of 670 kD<br />

Thyroglobulin is composed of two identical subunits, synthesized by the<br />

follicular epithelial cells of the thyroid.<br />

Also available as a Novocastra concentrate, refer to page 162.<br />

Hashimoto's thyroiditis: immunohistochemical staining with Bond ready-to-use Thyroglobulin<br />

(1D4) using Bond Polymer Refine Detection.<br />

/42<br />

For detailed information on all products please visit our website:<br />

www.leica-microsystems.com<br />

Thyroid Stimulating Hormone<br />

Clone QB2/6<br />

7 mL Bond ready-to-use PA0776 P (Enzyme)<br />

For In Vitro Diagnostic Use<br />

Thyroid stimulating hormone (TSH) is a pituitary hormone of 28 kD which<br />

stimulates thyroid g<strong>row</strong>th and production of thyroid hormones. TSH is<br />

reported to be expressed in thyrotrophic cells of the pituitary and pituitary<br />

adenomas.<br />

Also available as a Novocastra concentrate, refer to page 163.<br />

Pituitary gland: immunohistochemical staining with Bond ready-to-use Thyroid Stimulating<br />

Hormone (QB2/6) using Bond Polymer Refine Detection.<br />

Thyroid Transcription Factor-1<br />

Clone SPT24<br />

7 mL Bond ready-to-use PA0364 P (HIER)<br />

For In Vitro Diagnostic Use<br />

Thyroid Transcription Factor-1 (TTF-1) plays a role in regulating genes<br />

expressed in the thyroid, lung and brain. These include the genes encoding<br />

thyroglobulin, Clara cell secretory protein and surfactant proteins. Gene<br />

targeting studies have shown TTF-1 to be essential for the proper<br />

development of the thyroid and lungs; since abnormal expression may<br />

underline a number of congenital abnormalities.<br />

Product Specific Information<br />

Thyroid Transcription Factor-1 (SPT24) is recommended for use in the<br />

classification of tumors of the thyroid and lung.<br />

Also available as a Novocastra concentrate, refer to page 163.<br />

Lung tissue: immunohistochemical staining with Bond ready-to-use Thyroid Transcription<br />

Factor (SPT24) using Bond Polymer Refine Detection.<br />

Products in this catalog are subject to regulatory approval.<br />

This catalog is not for use in the USA.

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