Labelling Review row-Online

Primary Antibodies
CD35
Clone RLB25
1 mL, 0.1 mL lyophilized NCL-CD35 F P (Enzyme)
The CD35 antigen, also known as CR1 or C3b/C4b R, is a transmembrane
protein of 160 to 250 kD which binds complement components C3b and C4b.
It mediates phagocytosis by neutrophils and monocytes of particles coated
with C3b or C4b. CD35 antigen has an inhibitory effect on complement
activation by both the classical and alternative pathways. CD35 antigen is
reported to be found on erythrocytes, B cells, a subset of T cells, monocytes,
macrophages cultured in vitro, neutrophils, eosinophils, glomerular
podocytes and follicular dendritic cells. Decreased levels of CD35 antigen
has been reported on B cells in patients with HIV infection.
Normal human tonsil: immunohistochemical staining for CD35 antigen using NCL-CD35. Note
intense membrane staining of follicular dendritic cells. Paraffin section.
CD37
Clone CT1
1 mL lyophilized NCL-CD37 F P (HIER)
CD37 antigen is a member of the TM4 superfamily with a molecular weight of
40 to 52 kD. CD37 antigen was originally defined as an antigen of mature
B lymphocytes where it is highly expressed. It is reported not to be
expressed on pre-B cells or plasma cells and is expressed only at low level
in T cells, neutrophils, monocytes and some myelomonocytic leukemia cells.
NK cells, platelets and erythrocytes also do not express CD37 antigen. CD37
antigen on B cells associates non-covalently with MHC class II, CD19 and
CD21 antigens and with other TM4 superfamily molecules CD53, CD81 and
CD82.
/78
For detailed information on all products please visit our website:
www.leica-microsystems.com
CD38
Clone SPC32
1 mL, 0.1 mL lyophilized NCL-CD38-290 F P (HIER)
1 mL liquid NCL-L-CD38-290 F P (HIER)
The CD38 molecule is a type II single transmembrane glycoprotein with a
molecular weight of 46 kD. It is an ectoenzyme with the activities of ADPribosyl
cyclase, cyclic ADP-ribose hydrolase, NAD glycohydrolase and is
involved in both the formation and hydrolysis of cADPR, a second
messenger that regulates the mobilization of intracellular Ca 2+ ions.
Although the CD38 molecule was originally identified as a T lymphocyte
differentiation antigen, it is reported to be expressed in a wide range of cells
and tissues. CD38 antigen can deliver potent growth and differentiation
signals to lymphoid and myeloid cells. It is found on immature cells of the B
and T cell lineages but not on most mature resting peripheral lymphocytes. It
is also present on thymocytes, pre-B cells, germinal center B cells, mitogenactivated
T cells, Ig-secreting plasma cells, monocytes, NK cells, erythroid
and myeloid progenitors in the bone marrow and brain cells. CD38 antigen
has also been reported in neurofibrillary tangles, the pathological indicator
of Alzheimer's disease that occurs in the neuronal perikarya and proximal
dendrites.
Chronically inflamed human bronchus: immunohistochemical staining for CD38 antigen using
NCL-CD38-290. Note intense membrane staining of infiltrating activated T lymphocytes.
Paraffin section.
CD39
Clone 22A9
1 mL lyophilized NCL-CD39 P (HIER)
CD39 antigen is a transmembrane glycoprotein found on mature
B lymphocytes, follicular dendritic cells, endothelial cells, activated T cells,
NK cells and Langerhans cells. It is also known as E-type apyrase which
hydrolyses extracellular ATP and ADP, a function important to homotypic
adhesion and platelet aggression. CD39 antigen expressing cells may
provide protection from the toxic effects of ATP leaked from damaged cells.
CD39 antigen may enable tumor cells to reduce contact with T lymphocytes
and escape immunological recognition. Increased levels of CD39 antigen
expression are also reported to be associated with increased ectoATPase
activity that occurs during the progression of melanomas.
Human lymph node, B cell lymphoma: immunohistochemical staining for CD39 antigen using
NCL-CD39. Note intense membrane staining of tumor cells. Paraffin section.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.