Labelling Review row-Online

Origin
Synaptophysin
Clone 27G12
50 Tests ORG-8848 IVD
The Synaptophysin antigen is an integral membrane glycoprotein present in
many human normal and neoplastic neuroendocrine cells. It is reported to
occur in presynaptic vesicles of the neurons in the brain, spinal cord and
retina and in similar vesicles in the adrenal medulla and as well as
neuromuscular junctions. The synaptophysin antigen may be involved in
synaptic vesicle formation and exocytosis.
Product Specific Information
Synaptophysin (Clone 27G12) is recommended for the identification of tumors
of neuroendocrine origin and differentiation.
Refer to page 160 for further information about clone 27G12.
Origin Synaptophysin (Clone 27G12) on carcinoid tumor. Paraffin section.
Terminal Deoxynucleotidyl Transferase
Clone SEN28
50 Tests ORG-8865 IVD
Human TdT, a nuclear DNA polymerase with a molecular weight of 58 kD, is
reported to be expressed in primitive B and T cells of the normal thymus and
bone marrow, acute lymphoblastic lymphomas and leukemias.
Product Specific Information
The determination of TdT expression is reported to be most valuable when it
is difficult to differentiate histologically between lymphoblastic lymphoma
and Burkitts’ lymphoma, as such, Origin TdT (Clone SEN28) is recommended
for use in the diagnosis and differentiation of acute lymphoblastic leukemia/
lymphoma from other lymphomas.
Refer to page 162 for further information about Clone SEN28.
Origin TdT (Clone SEN28) on lymphoid leukemia. Paraffin section.
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