Labelling Review row-Online

CD45RO
Clone UCHL1
7 mL Bond ready-to-use PA0146 P (HIER)
For In Vitro Diagnostic Use
The CD45RO molecule, a 180 kD isoform of CD45, is reported to be expressed
on 48 percent of peripheral blood T lymphocytes, 37 percent of CD4 positive
lymphocytes, 80 percent of thymocytes and on the majority of T cell
malignancies. Monocytes and granulocytes show surface expression of the
antigen whereas tissue macrophages exhibit cytoplasmic expression.
Also available as a Novocastra concentrate, refer to page 81.
Follicular lymphoma: immunohistochemical staining with Bond ready-to-use CD45RO (UCHL1)
using Bond Polymer Refine Detection.
CD56
Clone CD564
7 mL Bond ready-to-use PA0191 P (HIER)
For In Vitro Diagnostic Use
The neural cell adhesion molecules are a family of closely-related cell
surface glycoproteins thought to play a role in embryogenesis, development
and contact-mediated interactions between neural cells. The CD56 antigen
(NCAM) consists of four major isoforms generated by differential splicing of
the RNA transcript from a single gene located on chromosome 5. The CD56
antigen is expressed on neurons, astrocytes, Schwann cells, NK cells and a
subset of activated T lymphocytes and some neuroendocrine tumors.
Also available as a Novocastra concentrate, refer to page 81.
Medullary carcinoma of the thyroid: immunohistochemical staining with Bond ready-to-use
CD56 (CD564) using Bond Polymer Refine Detection.
CD57
Clone NK-1
7 mL Bond ready-to-use PA0443 P (HIER)
For In Vitro Diagnostic Use
The CD57 glycoprotein, also known as HNK-1, has a molecular weight of 110
kD. It is found on a subset of mononuclear cells with natural killer activity
and on neuroectodermal cells expressing myelin-associated glycoprotein.
Many cells which co-express CD57 and CD8 proteins are a subset of
suppressor/cytotoxic T cells. These cells play a role in the rejection of grafts
in acute graft versus host disease. The CD57 molecule is not expressed on
erythrocytes or platelets.
Also available as a Novocastra concentrate, refer to page 82.
Sarcoma: immunohistochemical staining with Bond ready-to-use CD57 (NK-1) using Bond
Polymer Refine Detection.
CD61
Clone 2f2
7 mL Bond ready-to-use PA0308 P (HIER)
For In Vitro Diagnostic Use
The CD61 antigen, also known as GPIIIa, is a glycoprotein that is expressed on
platelets, megakaryocytes, monocytes, macrophages and endothelial cells.
CD61 combines with CD41 to form the platelet glycoprotein IIb/IIIb (integrin
aIibß3) and with CD51 to form the vitronectin receptor (integrin aVß3).
Product Specific Information
Bond ready-to-use CD61 (2f2) is recommended for use in detecting CD61
protein expression in a variety of normal and neoplastic tissues.
Also available as a Novocastra concentrate, refer to page 82.
Tonsil: immunohistochemical staining with Bond ready-to-use CD61 (2f2) using Bond Polymer
Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Bond