Labelling Review row-Online

Bond
Prostatic Acid Phosphatase
Clone PASE/4LJ
7 mL Bond ready-to-use PA0006 P
For In Vitro Diagnostic Use
Prostatic acid phosphatase (PAP) is an isoenzyme of acid phosphatase
found in large amounts in the prostate and seminal fluid. The precise
function of PAP is unknown, but it may act as a hydrolase to split phosphoryl
choline in semen and also function as a transferase. Elevated serum levels
of the enzyme are reported in metastatic prostatic carcinoma.
Also available as a Novocastra concentrate, refer to page 154.
Prostate adenocarcinoma: immunohistochemical staining with Bond ready-to-use Prostatic
Acid Phosphatase (PASE/4LJ) using Bond Polymer Refine Detection.
Protein Gene Product 9.5
Clone 10A1
7 mL Bond ready-to-use PA0286 P (HIER)
For In Vitro Diagnostic Use
Protein gene product (PGP) 9.5 is a neuron specific protein, structurally and
immunologically distinct from neuron specific enolase. PGP9.5 expression
has been reported in neurons and nerve fibers at all levels of the central and
peripheral nervous system, in many neuroendocrine cells, in segments of
the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and
in some cells of both the pregnant and non-pregnant corpus luteum. PGP9.5
is known to be a member of the ubiquitin C-terminal hydroxylase family and
is also concentrated within inclusion bodies suggesting that such structures
may be metabolically active regions of the cells.
Also available as a Novocastra concentrate, refer to page 154.
Small bowel nerve fibers: immunohistochemical staining with Bond ready-to-use Protein Gene
Product 9.5 (10A1) using Bond Polymer Refine Detection.
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S-100
Polyclonal
7 mL Bond ready-to-use PA0900 P (Enzyme)
For In Vitro Diagnostic Use
S-100 protein is reported to be expressed in neuroectodermal tissue, including
nerves and melanocytes. Langerhans’ cells in skin and interdigitating
reticulum cells in the paracortex of lymph nodes are also reported to express
S-100 protein.
Product Specific Information
S-100 (polyclonal) is recommended for use in a panel of antibodies for the
determination of tumors of neuroectodermal origin.
Also available as a Novocastra concentrate, refer to page 157.
Lung metastatic melanoma: immunohistochemical staining with Bond ready-to-use S-100
(Polyclonal) using Bond Polymer Refine Detection.
Serotonin
Polyclonal
7 mL Bond ready-to-use PA0736 P (HIER)
For In Vitro Diagnostic Use
Serotonin (5-hydroxytryptamine, 5-HT) is reported to be a widely distributed
neurotransmitter and hormone in the mammalian peripheral and central
nervous system (CNS). Serotonin is formed by the decarboxylation of 5hydroxy-tryptophan,
its intermediate, which in turn is formed by
hydroxylation of L-tryptophan by tryptophan hydroxylase. In the CNS, the
action of serotonin is terminated by reuptake into the presynaptic terminal
by specific serotonin transporters. Serotonin has been implicated in several
neuropsychiatric disorders such as anxiety, depression and schizophrenia.
The majority of serotonergic nerve terminals in the CNS originate in
neuronal cell bodies of the Raph nuclei (dorsal, median), nucleus Raph
obscurus and nucleus Raph pallidus in the brainstem which project to
specific areas of the brain and spinal cord. Serotonin is thought to be an
inhibitory neurotransmitter regulating a wide range of sensory, motor and
cortical functions in the CNS. In the periphery, serotonin is reported to be
present in neural and non-neural structures such as platelets, gastrointestinal
tract (myenteric plexus, enterochromaffin cells), lungs
(neuroepithelial cells), thyroid gland and spleen.
Also available as a Novocastra concentrate, refer to page 158.
Carcinoid: immunohistochemical staining with Bond ready-to-use Serotonin (Polyclonal) using
Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.