Labelling Review row-Online

Bond
Glial Fibrillary Acidic Protein
Clone GA5
7 mL Bond ready-to-use PA0026 P (HIER)
For In Vitro Diagnostic Use
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein of 52 kD
reported to be expressed in glial cells eg astrocytes and ependymal cells. In
the peripheral nervous system, GFAP has been reported to be expressed in
Schwann cells, enteric glial cells and satellite cells of human sensory
ganglia and in neoplastic tissues GFAP has been reported to be expressed in
astrocytomas and ependymomas.
Also available as a Novocastra concentrate, refer to page 114.
Astrocytes: immunohistochemical staining with Bond ready-to-use Glial Fibrillary Acidic
Protein using Bond Polymer Refine Detection.
Glucagon
Polyclonal
7 mL Bond ready-to-use PA0594 P
For In Vitro Diagnostic Use
Glucagon expression has been reported in the endocrine cells of the
pancreatic islets and also in the mucosa of the small and large intestine.
Pancreatic glucagon, a peptide of 29 amino acids, has biological activities
including glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. These
effects are all antagonistic to insulin action and, therefore, lead to increased
blood sugar levels. The majority of glucagonomas are reported to arise from
the pancreas and produce pancreatic glucagon. These tumors are found
chiefly in the main body or tail of the pancreas.
Also available as a Novocastra concentrate, refer to page 114.
Pancreas: immunohistochemical staining with Bond ready-to-use Glucagon (Polyclonal) using
Bond Polymer Refine Detection.
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Granzyme B
Clone 11F1
7 mL Bond ready-to-use PA0291 P (HIER)
For In Vitro Diagnostic Use
Granzymes are neutral serine proteases which are stored in specialized lytic
granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells.
These CTL and NK cells are heavily involved in the elimination of neoplastic
and virally infected cells. Secretory granules containing perforin and
granzymes are instrumental in undertaking cytolytic activity. Granzyme B is
understood to enter a target cell through a perforin pore-formed channel to
induce DNA fragmentation and apoptosis. Expression is also reported in
neoplastic CTL and NK cells.
Also available as a Novocastra concentrate, refer to page 116.
Spleen: immunohistochemical staining with Bond ready-to-use Granzyme B (11F1) using Bond
Polymer Refine Detection.
Gross Cystic Disease Fluid Protein-15
Clone 23A3
7 mL Bond ready-to-use PA0350 P (HIER)
For In Vitro Diagnostic Use
Gross cystic disease of the breast is a benign premenopausal disorder in
which cysts are a predominant pathological lesion. These cysts appear to
be formed from excessive apocrine cystic secretions. This fluid is composed
of several glycoproteins including a unique 15 kD monomer protein, GCDFP-
15. It has been reported that cytosolic analysis of normal tissue from all
major organs has demonstrated GCDFP-15 in apocrine epithelia, lacrimal,
ceruminous and Moll's glands and in numerous serous cells of the
submandibular, tracheal, bronchial, sublingual and minor salivary glands.
Cytosol from breast carcinoma lesions are reported to contain GCDFP-15 at
a wide range of concentrations. The concentration is reported to be highest
in more differentiated carcinomas and GCDFP-15 shows only a few positive
individual epithelial cells within lobules and small ducts in normal breast.
Expression has also been reported in fibroadenomas within areas of
apocrine metaplasia. GCDFP-15 and prostate specific antigen are reported
to be co-expressed in androgen receptor-positive breast tumors.
Also available as a Novocastra concentrate, refer to page 116.
Breast (Pagets Disease): immunohistochemical staining with Bond ready-to-use Gross Cystic
Disease Fluid Protein-15 (23A3) using Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.