Labelling Review row-Online

Bond
CD19
Clone BT51E
7 mL Bond ready-to-use PA0843 P (HIER)
For In Vitro Diagnostic Use
The CD19 molecule is a type I integral membrane glycoprotein with a
molecular weight of 90 kD. This antigen is reported to be expressed by all
normal B cells including early B cells. It is also found on follicular dendritic
cells, early cells of myelomonocytic lineage and most stabilized B cell lines.
The CD19 antigen is not present on T cells or on normal granulocytes.
Also available as a Novocastra concentrate, refer to page 74.
Normal tonsil: immunohistochemical staining with Bond ready-to-use CD19 (BT51E) using Bond
Polymer Refine Detection.
CD20
Clone MJ1
7 mL Bond ready-to-use PA0906 P (HIER)
For In Vitro Diagnostic Use
The CD20 antigen is thought to act as a receptor during B cell activation and
differentiation. It is expressed on normal and malignant B cells from
peripheral blood, lymph node, spleen, tonsil, bone marrow, acute leukemias
and chronic lymphocytic leukemias.
Product Specific Information
CD20 (MJ1) is recommended for use in the characterization of B cell
disorders as one component of a panel of antibodies.
Also available as a Novocastra concentrate, refer to page 75.
Tonsil: immunohistochemical staining with Bond ready-to-use CD20 (MJ1) using Bond Polymer
Refine Detection.
/20
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CD21
Clone 2G9
7 mL Bond ready-to-use PA0171 P (HIER)
For In Vitro Diagnostic Use
CD21 antigen is a type I integral membrane glycoprotein of molecular weight
140 kD, which functions as the receptor for the C3d fragment of the third
complement component. The CD21 molecule, present on mature B cells, is
involved in transmitting growth-promoting signals to the interior of the B cell
and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be
found in B cell chronic lymphocytic leukemias and in a subset of T cell acute
lymphocytic leukemias but is absent on T lymphocytes, monocytes and
granulocytes. CD21 antigen is also reported to be expressed in follicular
dendritic cells and in follicular and mantle cell lymphomas, mature
leukemias and lymphomas.
Also available as a Novocastra concentrate, refer to page 75.
Tonsil: immunohistochemical staining with Bond ready-to-use CD21 (2G9) using Bond Polymer
Refine Detection.
CD22
Clone FPC1
7 mL Bond ready-to-use PA0249 P (HIER)
For In Vitro Diagnostic Use
The CD22 antigen (BL-CAM) is a type 1 integral membrane glycoprotein with
a molecular weight of 130 to 140 kD. It is a heterodimer of two independently
expressed glycoprotein chains present both on the membrane and in the
cytoplasm of B lymphocytes. Expression of the CD22 antigen is reported to
appear early in B cell lymphocyte differentiation at approximately the same
stage as that of the CD19 antigen expression. Surface antigen expression is
variable and may be lost upon differentiation. CD22 antigen is also reported
to be weakly expressed on myeloid leukemias and non-T cell acute
lymphoblastic leukemias and is strongly expressed on hairy cell leukemias.
It is absent on peripheral blood T cells, T cell leukemias, granulocytes and
monocytes.
Also available as a Novocastra concentrate, refer to page 75.
Follicular lymphoma: immunohistochemical staining with Bond ready-to-use CD22 (FPC1) using
Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.