Labelling Review row-Online

CDX2
Clone AMT28
7 mL Bond ready-to-use PA0535 P (HIER)
For In Vitro Diagnostic Use
CDX2 is a caudal-type homeobox, intestine-specific transcription factor that
is expressed early in intestinal development and may be involved in the
regulation of proliferation and differentiation of intestinal epithelial cells.
CDX2, as well as CDX1, is of particular interest as the intestine is the only
organ that contains detectable levels of either gene product.
CDX2 is primarily expressed on the surface of the villus and in the crypts. In
contrast to CDX1, intense CDX2 expression is reported to occur in all but the
distal portions of the developing intestine. The loss of CDX2 has been reported
to contribute towards the progression of some sporadic colorectal cancers
and CDX2 may also be associated with carcinogenesis of the stomach, as
expression of CDX2 mRNA progressively decreases with the transition from
well differentiated to poorly differentiated gastric cancer cell lines.
Also available as a Novocastra concentrate, refer to page 89.
Bowel epithelium: immunohistochemical staining with Bond ready-to-use CDX2 (AMT28) using
Bond Polymer Refine Detection.
Chromogranin A
Clone 5H7
7 mL Bond ready-to-use PA0430 P (HIER)
For In Vitro Diagnostic Use
Chromogranin A is a 68 kD acidic protein that is reported to be widely
expressed in neural tissues and in secretory granules of human endocrine
cells; eg parathyroid gland, adrenal medulla, anterior pituitary gland, islet
cells of the pancreas and C cells of the thyroid. Chromogranin A expression
has been reported in neuroendocrine tumors such as pituitary adenomas,
islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas,
Merkel cell tumors and carcinoids.
Product Specific Information
Bond ready-to-use Chromogranin A (5H7) is recommended for use as part of
a panel of antibodies for the identification of tumors of neuroendocrine origin.
Also available as a Novocastra concentrate, refer to page 91.
Pancreas: immunohistochemical staining with Bond ready-to-use Chromogranin A (5H7) using
Bond Polymer Refine Detection.
Cytokeratin 5
Clone XM26
7 mL Bond ready-to-use PA0468 P (HIER)
For In Vitro Diagnostic Use
Cytokeratin 5 is closely related to Cytokeratin 6 and shares a similar tissue
distribution. The antigen is found in various proportions in many nonkeratinizing
stratified squamous and basal epithelia and epitheliomas.
Product Specific Information
Cytokeratin 5 (XM26) is recommended for the detection of Cytokeratin 5 in
normal and neoplastic tissues, especially in squamous cell carcinomas and,
when used as part of a panel of antibodies, for the distinction of
mesotheliomas from most adenocarcinomas.
Also available as a Novocastra concentrate, refer to page 95.
Infiltrating carcinoid of the bowel: immunohistochemical staining with Bond ready-to-use
Cytokeratin 5 (XM26) using Bond Polymer Refine Detection.
Cytokeratin 7
Clone RN7
7 mL Bond ready-to-use PA0942 P (HIER)
For In Vitro Diagnostic Use
Cytokeratin 7 is reported to be expressed in specific subtypes of
adenocarcinoma from ovary breast and lung whereas adenocarcinomas
from the gastrointestinal tract are negative.
Product Specific Information
Clone RN7 is recommended for use as part of an antibody panel in the
differential diagnosis of carcinomas.
Also available as a Novocastra concentrate, refer to page 96.
Ureter: immunohistochemical staining with Bond ready-to-use Cytokeratin 7 (RN7) using Bond
Polymer Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Bond