Labelling Review row-Online

CD23
Clone 1B12
7 mL Bond ready-to-use PA0169 P (HIER)
For In Vitro Diagnostic Use
CD23 antigen, the low affinity IgE receptor, is variably expressed on mantle
zone cells and on a sub-population of follicular dendritic cells. Although
CD23 is known to be expressed on other cells of hemopoietic origin,
expression is absent from a large range of nonlymphoid normal tissues.
Product Specific Information
CD23 is recommended for use within an antibody panel for the differential
diagnosis of small B cell lymphomas where it has been reported to be present
in small lymphocytic lymphomas and CLL (chronic lymphocytic leukemias).
Also available as a Novocastra concentrate, refer to page 76.
Tonsil: immunohistochemical staining with Bond ready-to-use CD23 (1B12) using Bond Polymer
Refine Detection.
CD25
Clone 4C9
7 mL Bond ready-to-use PA0305 P (HIER)
For In Vitro Diagnostic Use
CD25 antigen, the alpha subunit of interleukin-2 receptor, is a single-chain
glycoprotein with a molecular weight of 55 kD. Following the activation of
T cells interleukin-2 (IL-2) is rapidly synthesized and secreted. In response to
this a subpopulation of T cells expresses high affinity receptors for IL-2.
These cells proliferate, expanding the T cell population which is capable of
mediating helper, suppressor and cytotoxic functions. IL-2 receptor is not
exclusively found on T cells and is reported to be expressed on HTLVtransformed
T and B cells, EBV-transformed B cells, myeloid precursors and
oligodendrocytes. It is absent on thymocytes, resting T cells, non-activated
B cells and null cells. IL-2 receptor expression is reported to be associated
with inflammatory and malignant conditions, lymphoid neoplasia, autoimmune
diseases and allograft rejection.
Also available as a Novocastra concentrate, refer to page 125.
Tonsil, activated T cells and NK cells: immunohistochemical staining with Bond ready-to-use
CD25 (4C9) using Bond Polymer Refine Detection.
CD30
Clone JCM182
7 mL Bond ready-to-use PA0790 P (HIER)
Clone 1G12
7 mL Bond ready-to-use PA0153 P (HIER)
For In Vitro Diagnostic Use
The CD30 antigen is a single chain glycoprotein, known to act as a receptor
for cytokine ligand CD30L. It may play a part in the regulation of cellular
growth and transformation of activated lymphoblasts.
Product Specific Information
Bond ready-to-use CD30 is recommended for use as part of an antibody panel
for the identification of anaplastic large cell lymphomas and Hodgkin's
Lymphomas.
Also available as a Novocastra concentrate, refer to page 76.
Hodgkin's lymphoma: immunohistochemical staining with Bond ready-to-use CD30 (JCM182)
using Bond Polymer Refine Detection.
CD31
Clone 1A10
7 mL Bond ready-to-use PA0250 P (HIER)
For In Vitro Diagnostic Use
CD31 antigen (PECAM-1) is a single chain transmembrane glycoprotein
expressed on the surface of platelets, monocytes, granulocytes, B cells and at
the endothelial intracellular junction. The molecule has an extracellular
domain that contains six Ig-like homology units of C2 subclass, typical of cellto-cell
adhesion molecules. This domain is thought to mediate endothelial cellto-cell
adhesion, plays a role in endothelial contact and may serve to stabilize
the endothelial cell monolayer. The properties of CD31 antigen suggest that it
is involved in interactive events during angiogenesis, thrombosis and wound
healing. Angiogenesis is essential for tumor growth and metastases.
Product Specific Information
Bond ready-to-use CD31 (1A10) is recommended for use in the assessment of
vascular invasion in neoplastic tissues.
Also available as a Novocastra concentrate, refer to page 77.
Esophagus: immunohistochemical staining with Bond ready-to-use CD31 (1A10) using Bond
Polymer Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Bond