Labelling Review row-Online

Smooth Muscle Actin
Clone �sm-1
7 mL Bond ready-to-use PA0943 P
For In Vitro Diagnostic Use
Smooth muscle can be located in the vascular walls, intestinal muscularis
mucosae, muscularis propria and in the stroma of many tissues. They have
also been noted in the myoepithelial cells of various glands most notably the
salivary and mammary glands and in neoplastic tissues such as leiomyomas
and leiomyosarcomas.
Also available as a Novocastra concentrate, refer to page 57.
Appendix, smooth muscle: immunohistochemical staining with Bond ready-to-use Smooth
Muscle Actin (�sm-1) using Bond Polymer Refine Detection.
Somatostatin
Polyclonal
7 mL Bond ready-to-use PA0331 P
For In Vitro Diagnostic Use
Somatostatin is a cyclic polypeptide hormone originally isolated from the
hypothalamus and characterized by its ability to inhibit release of growth
hormone from the pituitary gland. It exists in two forms, somatostatin-14,
composed of 14 amino acids and somatostatin-28, a prohormone composed
of 28 amino acids. In the digestive system, somatostatin has been identified
in intrinsic nerves of the intestinal wall and in endocrine cells of the
digestive mucosa and the pancreatic islets. The antrum, duodenum and
pancreas have been reported to contain almost exclusively somatostatin-14,
whereas the gastric body and the rest of the intestine contain 40 to 80
percent somatostatin-28.
Product Specific Information
Somatostatin (polyclonal) is specific for D cells of the mammalian pancreas
and cells of the hypothalamic parvicellular region.
Pancreas: immunohistochemical staining with Bond ready-to-use Somatostatin (Polyclonal)
using Bond Polymer Refine Detection.
Synaptophysin
Clone 27G12
7 mL Bond ready-to-use PA0299 P (HIER)
For In Vitro Diagnostic Use
Synaptophysin is an integral membrane glycoprotein. It is reported to occur
in presynaptic vesicles of neurons in brain, spinal cord, retina and in similar
vesicles of the adrenal medulla as well as in neuromuscular junctions.
Synaptophysin may be involved in synaptic vesicle formation and exocytosis
and as such is reported to be expressed in a wide spectrum of neuroendocrine
tumors.
Product Specific Information
Bond ready-to-use Synaptophysin (27G12) is recommended for the
identification of tumors of neuroendocrine origin and differentiation.
Also available as a Novocastra concentrate, refer to page 160.
Carcinoid: immunohistochemical staining with Bond ready-to-use Synaptophysin (27G12) using
Bond Polymer Refine Detection. Note intense cytoplasmic staining of tumor cells.
Tartrate-Resistant Acid Phosphatase
(TRAP)
Clone 26E5 New!
7 mL Bond ready-to-use PA0093 P (HIER)
For In Vitro Diagnostic Use
Tartrate-resistant acid phosphatase (TRAP) is a basic, iron-binding protein
with high activity towards phosphoproteins, ATP and 4-nitrophenyl
phosphate. This isoenzyme has been reported through different applications
to be expressed in human alveolar macrophages, osteoclasts, spleen and
liver. Expression of TRAP is reported to be increased in the spleen and
monocytes of individuals with Gaucher's disease, Hodgkin's disease and the
sera of individuals undergoing active bone turnover. Elevated levels are also
reported to be associated with various B cell and T cell leukemias and
lymphomas, decidual cells, syncytiotrophoblasts and some macrophages
distributed throughout maternal and embryonic tissues.
Also available as a Novocastra concentrate, refer to page 161.
Hairy cell leukemia: immunohistochemical staining with Bond ready-to-use Tartrate-Resistant
Acid Phosphatase (26E5) using Bond Polymer Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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