Labelling Review row-Online

Primary Antibodies
Human infant lung, post-mortem tissue: immunohistochemical staining for Respiratory
syncytial virus (RSV) using NCL-RSV3. Note intense staining of infected luminal bronchial
epithelial cells. Paraffin section.
Retinoblastoma Gene Protein
Clone 13A10
1 mL, 0.1 mL lyophilized NCL-RB-358 F P (HIER) W
1 mL liquid NCL-L-RB-358 F P (HIER) W
Clone 1F8
1 mL lyophilized NCL-RB F P (HIER) W
Clone 13A10 was developed to produce superior staining on paraffin
sections.
Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations
of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor
suppressor gene is present in many cells and may indirectly regulate cell
growth by activating the transcription factor ATF-2. Activation of ATF-2
initiates expression of TGF-beta2, which in turn inhibits transcription of
genes affecting cell growth. Bilateral mutation of the Rb gene may
potentially play a role in the development of a number of malignant tumors.
Product Specific Information
NCL-RB-358 was raised to the N-terminal region of the Rb gene protein.
Human tonsil: immunohistochemical staining for retinoblastoma gene protein using NCL-RB-
358. Note intense nuclear staining of epithelial cells. Paraffin section.
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ret Oncoprotein
Clone 3F8
1 mL, 0.1 mL lyophilized NCL-RET P (HIER)
The ret proto-oncogene encodes a cell surface glycoprotein belonging to a
member of the receptor tyrosine kinase family and is located on
chromosome 10q11.2. Three main 3' splice isoforms have been characterized
from papillary thyroid carcinomas, themselves originating from thyroid
epithelial cells. ret expression is reported in several regions of the central
nervous system; in the developing cranial nerve ganglia and a subset of
cells within dorsal root ganglia, in motor neurons in the spinal cord and
hindbrain, in neuroretina and the growing tips of the renal collecting ducts in
developing kidney. Some individuals with Hirschsprung's disease have
severe developmental abnormalities of the kidney and these phenotypic
abnormalities may be linked with mutations of ret proto-oncogene. About 70
percent of individuals who carry one of the documented ret mutations that
predispose to multiple endocrine neoplasia type II (MENII) will develop
thyroid C cell derived tumors in their lifetime.
Product Specific Information
NCL-RET was raised to the intracellular domain of the molecule, present in all
isoforms of the protein. Mutations are reported to occur upstream of this
domain.
Human small intestine: immunohistochemical staining for ret oncoprotein using NCL-RET.
Note cytoplasmic staining of enteric ganglion cells. Paraffin section.
RHAMM (CD168)
Clone 2D6
1 mL lyophilized NCL-CD168 F P (HIER)
Refer to page 88 for further information about CD168.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.