Labelling Review row-Online

Bond
CD68
Clone 514H12
7 mL Bond ready-to-use PA0273 P (HIER)
For In Vitro Diagnostic Use
The CD68 antigen is an intracellular molecule, which has primarily been
associated with cytoplasmic granules and, to a lesser extent, the membranes
of macrophages, monocytes, neutrophils, basophils and large
lymphocytes. CD68 expression has been reported in stimulated T cells, NK
cells, lymphomas, sarcomas and carcinomas, and in liver and renal tubules.
Product Specific Information
The CD68 antigen can be identified in a variety of normal and neoplastic
tissues using CD68 (514H12).
Also available as a Novocastra concentrate, refer to page 83.
Tonsil: immunohistochemical staining with Bond ready-to-use CD68 (514H12) using Bond
Polymer Refine Detection.
CD79a
Clone 11E3
7 mL Bond ready-to-use PA0192 P (HIER)
For In Vitro Diagnostic Use
The CD79 complex is associated with membrane-bound immunoglobulins on
B cells, with these immunoglobulins the two subunits, CD79a and CD79b
constitute the B cell antigen receptor. The CD79a component is reported to
first appear at the pre-B cell stage, early maturation, and persists until the
plasma cell stage where it is found as an intracellular component. The
CD79a antigen is reported to be expressed in the majority of acute leukemias
of precursor B cell type, B cell lines, B cell lymphomas and in some
myelomas. It is not present in myeloid or T cell lines.
Also available as a Novocastra concentrate, refer to page 84.
Tonsil, B cell-plasma cell transition: immunohistochemistry staining with Bond ready-to-use
CD79a (11E3) using Bond Polymer Refine Detection.
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CD99
Clone 12E7
7 mL Bond ready-to-use PA0509 P
For In Vitro Diagnostic Use
CD99 antigen, a 32 kD glycoprotein, is also known as MIC2, E2, 12E7, HuLym6
or FMC29. CD99 antigen is reported to be expressed on cortical
thymocytes and T lymphocytes and is involved in rosette formation with
sheep or human erythrocytes. It is also expressed on granulosa cells of the
ovary, most pancreatic islet cells, Sertoli cells of the testis and on some
endothelial cells. CD99 antigen is reported to be strongly expressed on
Ewing's sarcoma cells and primitive peripheral neuroectodermal tumors.
Also available as a Novocastra concentrate, refer to page 85.
Ewing’s sarcoma: immunohistochemical staining with Bond ready-to-use CD99 (12E7) using
Bond Polymer Refine Detection.
CD138 (Syndecan 1)
Clone MI15 New!
7 mL Bond ready-to-use PA0088 P (HIER)
For In Vitro Diagnostic Use
The CD138 molecule is a transmembrane heparan sulphate glycoprotein
expressed at distinct stages of differentiation in normal lymphoid cells such
as pre-B cells, immature B cells and Ig-producing plasma cells as well as
being expressed in stratified and simple epithelia. The loss of CD138
expression from atypical cells is reported to be an early event during
cervical carcinogenesis whereas CD138 antigen expression shows a close
association with preserved epithelial morphology and differentiation,
however, the major utility of CD138 as a marker in immunohistochemistry is
the quantification of plasma cells.
Plasmacytoma: immunohistochemical staining with Bond ready-to-use CD138 (Synedcan-1)
(MI15) using Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.