Labelling Review row-Online

Human benign nodular hyperplasia of prostate: immunohistochemical staining for cytokeratins
using RTU-AE1/AE3. Note intense cytoplasmic staining of glandular myoepithelial cells.
Paraffin section.
Multi-Cytokeratin (4/5/6/8/10/13/18)
Clone C-11
1 mL lyophilized NCL-C11 F P (HIER)
Cytokeratins 4, 5, 6, 8, 10, 13 and 18 are differentially expressed between a
variety of normal, reactive and neoplastic epithelia and also simple
epithelium and both basal and suprabasal layers of cornifying and noncornifying
squamous epithelium.
NCL-C11 is reported to react with human cytokeratins 4, 5, 6, 8, 10, 13 and 18.
Multi-Cytokeratin 1/5/10/14
Clone 34�E12
1 mL lyophilized NCL-CK34BE12 F P (HIER) W
7 mL ready-to-use RTU-CK34BE12 F P (HIER)
7 mL Bond ready-to-use PA0134 P (Enzyme)
NCL-CK34�E12 reacts with human cytokeratin intermediate filament
proteins 1, 5, 10 and 14. The antibody is reported to react with squamous
epithelium and sweat ducts in normal skin, some pneumocytes, bronchial
epithelium and mesothelium in normal lung and bile ducts in normal liver. It
also reacts with ductal cells of the normal pancreas, some acinar and ductal
cells of normal breast, some follicular epithelia of normal thyroid and some
epithelia and mesothelium of the normal small and large bowel.
Refer to page 27 for the Bond ready-to-use format.
Multi-Cytokeratin (5/6/8/18)
5D3, Clone LP34
1 mL, 0.1 mL lyophilized NCL-CK5/6/8/18 F P (Enzyme)
1 mL liquid NCL-L-CK5/6/8/18 F P (Enzyme)
7 mL ready-to-use RTU-CK5/6/8/18 F P (Enzyme)
Product Specific Information
NCL-CK5/6/8/18, NCL-L-CK5/6/8/18 and RTU-CK5/6/8/18 react with human
cytokeratins 5, 6, 8 and 18. These products are cocktails of monoclonal
antibodies designed to recognize cytokeratins reported to be expressed in
almost all epithelial tissues.
Human squamous cell carcinoma of the floor of the mouth: immunohistochemical staining for
cytokeratins using NCL-L-CK5/6/8/18. Note intense cytoplasmic staining of malignant cells.
Paraffin section.
Multidrug Resistance-Associated
Protein Antibodies
Clone 33A6
1 mL, 0.1 mL lyophilized Multidrug Resistance-associated
Protein 1 NCL-MRP1 P (HIER)
Clone DTX1
1 mL lyophilized Multidrug Resistance-associated
Protein 3 NCL-MRP3 P (HIER)
The human multidrug resistance-associated protein (MRP) gene family
contains at least 6 members designated MRP1 to 6. MRP1 is a
phosphoprotein of 1531 amino acids and is expressed in a variety of cell
types. MRP1 mRNA has been demonstrated in lung, testis and peripheral
blood mononuclear cells but was not detected in placenta, brain, salivary
gland, liver, uterus and spleen. The protein has been expressed in the
epithelium and glands of nasal respiratory mucosa. MRP3 is a 190 to 200 kD
integral membrane protein which is an organic anion transporter effective in
transporting chemotherapeutic drugs such as MTX, etoposide and
teniposide. Northern blotting of various human tissues has indicated MRP3
to be expressed in liver, colon, pancreas and at lower levels in the kidney.
MRP5 mRNA is reported to be expressed in almost all tissues, especially
skeletal muscle and brain with lower expression observed in liver, adrenal
gland, placenta, ovary and pancreas.
Human ovary: immunohistochemical staining for multidrug resistance-associated protein 1
using NCL-MRP1. Note cytoplasmic staining of granulosa and thecal cells. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Primary Antibodies