Labelling Review row-Online

Bond
Endothelium: immunohistochemical staining with Bond ready-to-use von Willebrand Factor
(36B11) using Bond Polymer Refine Detection.
Wilms' Tumor
Clone WT49
7 mL Bond ready-to-use PA0562 P (HIER)
For In Vitro Diagnostic Use
Wilms' tumor protein (WT1) has a role in transcriptional regulation and is
expressed in the kidney and a subset of hematopoietic cells. Alteration of
transcription factor function is a common mechanism in oncogenesis. The
WT1 protein contains a DNA binding domain and any deletions or point
mutations of the WT1 gene which destroy this activity result in the
development of the childhood nephroblastoma Wilms' tumor and Denys-
Drash syndrome. The tumor is reported to arise from the embryonic
metanephric mesenchyme cells in a disorganized array and affects 1 in
10,000 live births. Mutations of the WT1 gene are observed in only 10 to 20
percent of sporadic Wilms' tumors, but may be present in another range of
tumors derived from the urogenital tract and mesothelium. Wilms' tumor
protein is also reported to be expressed in a range of human cancers
including breast, acute myeloid leukemia and mesothelioma. Wilms' tumor
protein is often used as part of a panel of antibodies to sub type small round
blue cell tumors.
Also available as a Novocastra concentrate, refer to page 170.
Wilms' tumor: immunohistochemical staining with Bond ready-to-use Wilms' tumor (WT49)
using Bond Polymer Refine Detection.
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ZAP-70
Clone L453R
7 mL Bond ready-to-use PA0998 P (HIER)
For In Vitro Diagnostic Use
ZAP-70 is a member of the syk family of proteins. It is expressed on T cells
and NK cells and is required for the T cell receptor activation that triggers
an immune response. CLL B cells that express the non-mutated
immunoglobulin VH genes express levels of ZAP-70 protein that are
comparable to those found in the blood T cells of healthy adults. Leukemic
cells that express mutated IgVH genes generally do not express detectable
levels of ZAP-70 protein and this is correlated with the high level expression
of CD38. The ZAP-70 positive sub-type has been reported to be associated
with a more aggressive phenotype.
Also available as a Novocastra concentrate, refer to page 171.
Tonsil: immunohistochemical staining with Bond ready-to-use ZAP-70 (L453R) using Bond
Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.