Labelling Review row-Online

Mast Cell Tryptase
Clone 10D11
7 mL Bond ready-to-use PA0019 P
For In Vitro Diagnostic Use
Mast cells contain a number of preformed chemical mediators such as
histamine, chymase, carboxypeptidase and proteolytic tryptase. A
substantial quantity of tryptase is reported to be found in mast cells of skin
and lung and suggests this enzyme plays a major role in mast cell mediated
events. In vitro studies indicate tryptase can cleave C3 to form C3a
anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin
and activate latent collagenase. Models of allergenic disease in the skin,
nose and lung have each indicated elevated tryptase levels. Human mast
cell tryptase has been reported to be implicated as a mediator of
inflammation. Mast cell degranulation in the gut causes mucus secretion,
mucosal edema, increased gut permeability and may be responsible for
some of the symptoms and signs of inflammatory bowel disease.
Also available as a Novocastra concentrate, refer to page 130.
Bowel: immunohistochemical staining with Bond ready-to-use Mast Cell Tryptase (10D11)
using Bond Polymer Refine Detection.
Melan A
Clone A103
7 mL Bond ready-to-use PA0233 P (HIER)
For In Vitro Diagnostic Use
Melan A, a product of the MART-1 gene, is a melanocytic differentiation
marker recognized by autologous cytotoxic T lymphocytes.
Product Specific Information
Melan A (A103) is employed in the assessment of Melan A in melanocytic
lesions.
Also available as a Novocastra concentrate, refer to page 132.
Malignant melanoma: immunohistochemical staining with Bond ready-to-use Melan A (A013)
using Bond Polymer Refine Detection.
Mesothelin
Clone 5B2
7 mL Bond ready-to-use PA0373 P (HIER)
For In Vitro Diagnostic Use
Mesothelin is present on the surface of mesothelial cells, mesothelioma,
epithelial ovarian cancers and some squamous cell carcinomas. Mesothelin
is abundantly expressed in the kidney and in occasional epithelial cells of
the trachea, tonsil and fallopian tube. The function of mesothelin is unclear
but it may have a role in cellular adhesion.
Product Specific Information
Mesothelin is reported to be abundant in the normal mesothelial cells from
which malignant mesothelioma and ovarian cystadenocarcinomas are
derived. As such, Bond ready-to-use Mesothelin (5B2) is recommended for
use as part of a panel of antibodies to distinguish mesotheliomas and ovarian
cystadenocarcinomas from other solid tumors.
Mesothelin (5B2) is recommended for use as part of a panel of antibodies to
distinguish mesotheliomas and ovarian cystadenocarcinomas from other
solid tumors.
Also available as a Novocastra concentrate, refer to page 133.
Mesothelioma: immunohistochemical staining with Bond ready-to-use Mesothelin (5B2) using
Bond Polymer Refine Detection.
MLH1 (Mismatch Repair Protein)
Clone ES05 New!
7 mL Bond ready-to-use PA0610 P (HIER)
For In Vitro Diagnostic Use
MLH1, a mismatch repair protein involved in maintaining the integrity of
genetic information, alongside MSH2, MSH6 and PMS2. During DNA
replication, strand misalignment can occur resulting in alterations to
microsatellite repeats, often referred to as microsatellite instability (MSI).
These defects in DNA repair pathways have been linked to human
carcinogenesis. Mutations in the MLH1 gene have been reported to be
found in tumors with MSI, such as some forms of colon cancer eg
Hereditary nonpolyposis colon cancer (HNPCC), a subset of sporadic
carcinomas and breast cancer. Loss of expression of MLH1 has also been
reported in acute lymphoblastic leukemia, endometrial carcinoma, gastric
carcinoma and ovarian carcinoma.
Also available as a Novocastra concentrate, refer to page 134.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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