Labelling Review row-Online
Labelling Review row-Online
Labelling Review row-Online
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Human bone mar<strong>row</strong>: immunohistochemical staining for CD19 using NCL-L-CD19-163. Note<br />
membrane staining of B cells. Paraffin section.<br />
CD20<br />
Clone 7D1<br />
1 mL, 0.1 mL lyophilized NCL-CD20-7D1 F P (HIER) W<br />
Reference Range<br />
Clone MJ1<br />
1 mL, 0.1 mL lyophilized NCL-CD20-MJ1 F P (HIER)<br />
7 mL Bond ready-to-use PA0906 P (HIER)<br />
Clone L26<br />
1 mL lyophilized NCL-CD20-L26 F P (HIER) W<br />
1 mL liquid NCL-L-CD20-L26 F P (HIER) W<br />
7 mL ready-to-use RTU-CD20-L26 F P (HIER)<br />
Clone 7D1 was developed to produce superior manual staining on paraffin<br />
sections.<br />
The CD20 antigen is a non-glycosylated phosphoprotein of approximately<br />
33 kD which is expressed on normal and malignant human B cells and is<br />
thought to act as a receptor during B cell activation and differentiation.<br />
CD20 antigen has been reported to be expressed on normal B cells from<br />
peripheral blood, lymph node, spleen, tonsil, bone mar<strong>row</strong>, acute leukemias<br />
and chronic lymphocytic leukemias.<br />
Refer to page 20 for the Bond ready-to-use format.<br />
Human centroblastic lymphoma: immunohistochemical staining for CD20 antigen using<br />
NCL-CD20-7D1. Note intense membrane staining of B cells. Paraffin section.<br />
CD21<br />
Clone 2G9<br />
1 mL, 0.1 mL lyophilized NCL-CD21-2G9 F P (HIER)<br />
1 mL liquid NCL-L-CD21-2G9 F P (HIER)<br />
7 mL Bond ready-to-use PA0171 P (HIER)<br />
CD21 antigen is a type I integral membrane glycoprotein of molecular weight<br />
140 kD, which functions as the receptor for the C3d fragment of the third<br />
complement component. The CD21 molecule, present on mature B cells, is<br />
involved in transmitting g<strong>row</strong>th-promoting signals to the interior of the B cell<br />
and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be<br />
found in B cell chronic lymphocytic leukemias and in a subset of T cell acute<br />
lymphocytic leukemias but is absent on T lymphocytes, monocytes and<br />
granulocytes. CD21 antigen is also reported to be expressed in follicular<br />
dendritic cells and in follicular and mantle cell lymphomas, mature<br />
leukemias and lymphomas.<br />
Refer to page 20 for the Bond ready-to-use format.<br />
Human follicular lymphoma: immunohistochemical staining for CD21 antigen using NCL-CD21-<br />
2G9. Note intense membrane staining of follicular dendritic cells. Paraffin section.<br />
CD22 (BL-CAM)<br />
Clone FPC1<br />
1 mL, 0.1 mL lyophilized NCL-CD22-2 P (HIER)<br />
7 mL Bond ready-to-use PA0249 P (HIER)<br />
The CD22 antigen (BL-CAM) is a type 1 integral membrane glycoprotein with<br />
a molecular weight of 130 to 140 kD. It is a heterodimer of two independently<br />
expressed glycoprotein chains, present both on the membrane and in the<br />
cytoplasm of B lymphocytes. Expression of the CD22 antigen is reported to<br />
appear early in B cell lymphocyte differentiation at approximately the same<br />
stage as that of the CD19 antigen expression. Surface antigen expression is<br />
variable and may be lost upon differentiation. CD22 antigen is also reported<br />
to be strongly expressed on hairy cell leukemias. It is absent on peripheral<br />
blood T cells, T cell leukemias, granulocytes and monocytes.<br />
Refer to page 20 for the Bond ready-to-use format.<br />
F Frozen I Immunofluorescence E Electron microscopy<br />
P Paraffin C Flow cytometry O Other applications<br />
W Western blotting<br />
/75<br />
Primary Antibodies