Labelling Review row-Online

Bond
Myeloperoxidase
Clone 59A5 New!
7 mL Bond ready-to-use PA0491 P
For In Vitro Diagnostic Use
Myeloperoxidase is a lysosomal enzyme found in cells of the myeloid series
which metabolises most of the hydrogen peroxide generated by activated
phagocytes. It is a major constituent of azurophilic cytoplasmic granules
that uses hydrogen peroxide to oxidise a variety of aromatic compounds and
chloride ions to hypochlorous acid (HOCI), a strong oxidant. HOCI is the most
bacteriocidal oxidant known to be produced by neutrophils. HOCI reacts
with proteins to form cytotoxic chloramines. Myeloperoxidase is reported to
be a major component in all myeloid cells, including mature granulocytes
and is a superior marker to myeloperoxidase mRNA, whose level decreases
with the maturation of the cell and is not detectable from the myelocyte
stage onwards. Myeloperoxidase is reported to be expressed in neutrophil
granulocytes and monocytes in blood, in precursors of granulocytes in the
bone marrow and in Kupffer cells of the liver.
Also available as a Novocastra concentrate, refer to page 139.
Acute myeloid leukemia: immunohistochemical staining with Myeloperoxidase (59A5) using
Bond Polymer Refine Detection.
Myf-4 (Rhabdomyosarcoma Marker)
Clone LO26
7 mL Bond ready-to-use PA0226 P (HIER)
For In Vitro Diagnostic Use
Rhabdomyosarcomas are a class of myoblast-derived soft tissue sarcomas
that usually express a number of muscle-specific genes and primarily affect
children and young adults. Differentiation of myogenic cells is controlled by
a set of regulatory genes including MyoD1, myogenin, Myf-5 and Myf-6.
Myf-4 is the human homolog of myogenin. Its gene product, together with
that of The, accumulates in the nucleus of differentiated cells. Myf-4 has
been shown to be useful in the sub typing of small round blue cell tumors.
Also available as a Novocastra concentrate, refer to page 139.
Rhabdomyosarcoma: immunohistochemical staining with Bond ready-to-use Myf-4
(Rhabdomyosarcoma Marker) (LO26) using Bond Polymer Refine Detection.
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Myoglobin
Clone MYO18
7 mL Bond ready-to-use PA0727 P (HIER)
For In Vitro Diagnostic Use
Myoglobin is a cytoplasmic, single chain polypeptide of 153 amino acids that
contains a single heme group. Myoglobin is reported to be expressed in
skeletal and cardiac muscle but not in smooth muscle and functions as an
oxygen transporting pigment.
Also available as a Novocastra concentrate, refer to page 139.
Rhabdomyosarcoma: immunohistochemical staining with Bond ready-to-use Myoglobin
(MYO18) using Bond Polymer Refine Detection.
Myosin Heavy Chain (Smooth Muscle)
Clone S131
7 mL Bond ready-to-use PA0493 P (HIER)
For In Vitro Diagnostic Use
Myosin is a contractile muscle specific protein composed of two heavy and four
light chains. The myosin heavy chain has many isoforms which are specific for
different muscles or fiber types, some of which are developmentally regulated.
Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural
protein that is a major component of the contractile apparatus in smooth muscle
cells. It has been reported to be specific for smooth muscle development.
Also available as a Novocastra concentrate, refer to page 140.
Prostate: smooth muscle immunohistochemical staining with Bond ready-to-use Myosin Heavy
Chain (smooth muscle) (S131) using Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.