Labelling Review row-Online

Primary Antibodies
Prostatic Acid Phosphatase
Clone PASE/4LJ
1 mL liquid NCL-L-PAP FP
7 mL Bond ready-to-use PA0006 P (HIER)
Prostatic acid phosphatase (PAP) is an isoenzyme of acid phosphatase
found in large amounts in the prostate and seminal fluid. The precise
function of PAP is unknown, but it may act as a hydrolase to split phosphoryl
choline in semen and also function as a transferase. Elevated serum levels
of the enzyme are reported in metastatic prostatic carcinoma.
Refer to page 40 for the Bond ready-to-use format.
Prostate adenocarcinoma: immunohistochemical staining with Prostatic Acid Phosphatase
(PASE/4LJ) using Bond Polymer Refine Detection.
Prostatic Inhibin Peptide
Clone 4A6A6
1 mL lyophilized NCL-PIP P
Prostatic inhibin peptide (PIP), a 10.7 kD follicle stimulating hormone
suppressing molecule, is synthesized and secreted by the prostate gland.
PIP has been reported to be expressed in primary prostatic tumors and their
metastases. PIP has also been reported to be expressed in the serum and
urine of patients with prostatic cancer. PIP expression is unaffected by
reduced or absent androgens unlike both PSA and PAP whose expression is
dependent on androgens.
Human prostate gland: immunohistochemical staining for prostatic inhibin peptide using
NCL-PIP. Note cytoplasmic staining of glandular epithelium. Paraffin section.
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Protein Gene Product 9.5
Clone 10A1
1 mL, 0.1 mL lyophilized NCL-PGP9.5 F P (HIER) W
1 mL liquid NCL-L-PGP9.5 F P (HIER) W
7 mL Bond ready-to-use PA0286 P (HIER)
Protein gene product (PGP) 9.5 is a neuron specific protein, structurally and
immunologically distinct from neuron specific enolase. The protein which
has a molecular weight of 27 kD was first identified by high resolution two
dimensional PAGE. PGP9.5 expression has been reported in neurons and
nerve fibers at all levels of the central and peripheral nervous system, in
many neuroendocrine cells, in segments of the renal tubules, in
spermatogonia and Leydig cells of the testis, in ova and in some cells of both
the pregnant and non-pregnant corpus luteum. PGP9.5 is known to be a
member of the ubiquitin C-terminal hydroxylase family and is also
concentrated within inclusion bodies suggesting that such structures may
be metabolically active regions of the cells.
Refer to page 40 for the Bond ready-to-use format.
pS2 Protein
Polyclonal
0.5 mL lyophilized NCL-pS2 FP
pS2, also known as pNR-2, was first identified by differential screening of
cDNA libraries from estrogen responsive breast cancer cell lines. In normal
tissue, pS2 protein is reported to be expressed in gastric mucosa, small
intestinal mucosa and normal breast epithelium. pS2 is estrogen regulated in
breast cancer cell lines and may have some growth factor activity. In
malignant epithelial tumors, pS2 has been reported to be expressed in
gastric carcinomas and gynecological cancers. The pS2 mRNA and protein
are expressed predominantly in estrogen receptor positive breast cancers.
Human breast carcinoma: immunohistochemical staining for pS2 protein using NCL-pS2.
Note cytoplasmic staining of a proportion of tumor cells. Paraffin section.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.