Labelling Review row-Online

CD5
Clone 4C7
50 Tests ORG-8919 IVD
CD5 is a protein of 67 kD, expressed on 95 percent of thymocytes and 72
percent of peripheral blood lymphocytes. In lymph nodes, the main reactivity
is observed on T cells. CD5 antigen is expressed by many T cell lymphomas,
activated T cells and on a subset of B cells. CD5 antigen expression is
reported in T cell acute lymphocytic leukemias (T-ALL), some B cell chronic
lymphocytic leukemias (B-CLL) as well as B and T cell lymphomas. CD5
antigen is not expressed in follicular cell lymphomas.
Product Specific Information
Origin CD5 (Clone 4C7) can be used in the differential diagnosis of lymphomas,
including mantle cell lymphomas.
Refer to page 71 for further information about Clone 4C7.
Origin CD5 (Clone 4C7) on spleen. Paraffin section.
CD8
Clone 1A5
50 Tests ORG-8936 IVD
The CD8 molecule is composed of two chains and has a molecular weight of
32 kD. It has been found on a subset of normal cytotoxic/suppressor cells
which make up approximately 20-35 percent of human peripheral blood
lymphocytes. The CD8 molecule is reported to be detected on natural killer
cells, 80 percent of thymocytes, on a sub-population of 30 percent of
peripheral blood null cells and 15-30 percent of bone marrow cells.
Product Specific Information
T cell disorders may be characterized using Origin CD8 (Clone 1A5) as part of
a panel of antibodies.
Refer to page 72 for further information about Clone 1A5.
Origin CD8 (Clone 1A5) on tonsil. Paraffin section.
CD10
Clone 56C6
50 Tests ORG-8941 IVD
CD10 antigen is also known as neprilysin and common acute lymphoblastic
leukemia antigen (CALLA). CD10 antigen is expressed on a wide variety of
normal and neoplastic cells.
Product Specific Information
CD10 expression is reported on cells of lymphoblastic, Burkitts’ and follicular
lymphomas and on B cells from patients with chronic myelocytic leukemia, as
such, Origin CD10 (Clone 56C6) may be used in the differential diagnosis of
small B cell lymphoma and the subtyping of lymphoblastic leukemia.
Refer to page 73 for further information about Clone 56C6.
Origin CD10 (Clone 56C6) on lymphoma. Paraffin section.
CD23
Clone 1B12
50 Tests ORG-8826 IVD
The CD23 antigen, a membrane glycoprotein of 45 kD, is reportedly found on
a subpopulation of peripheral blood cells, B lymphocytes and on EBVtransformed
B lymphoblastoid cell lines. The CD23 molecule is also known
as the low affinity IgE receptor found on B cells. Expression has been
reported on neoplastic cells from B cell chronic lymphocytic leukemias and
centrocytic/centroblastic lymphomas.
Product Specific Information
Origin CD23 (Clone 1B12) is recommended for use in the differential diagnosis
of small B cell lymphomas.
Refer to page 76 for further information about Clone 1B12.
Origin CD23 (Clone 1B12) on tonsil. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Origin