Labelling Review row-Online

Origin
bcl-2 Oncoprotein
Clone bcl-2/100/D5
50 Tests ORG-8714 IVD
Bcl-2 antigen is a member of a family of proteins that are involved in
apoptosis. The antigen is an integral inner mitochondrial membrane protein
of 25 kD and has wide tissue distribution. It is considered to act as an
inhibitor of apoptosis. For this reason bcl-2 expression is inhibited in
germinal centers where apoptosis forms part of the B cell production
pathway. In 90 percent of follicular lymphomas a translocation occurs which
juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene, with
subsequent deregulation of gene expression and cell proliferation.
Product Specific Information
Origin bcl-2 (Clone bcl-2/100/D5) is recommended for use in the differentiation
of lymphomas from reactive lymph nodes.
Refer to page 60 for further information about Clone bcl-2/100/D5.
Origin bcl-2 (Clone bcl-2/100/D5) on tonsil. Paraffin section.
CD1a
Clone JPM30
50 Tests ORG-8968 IVD
CD1a is a protein of 43 to 49 kD expressed on dendritic cells and cortical
thymocytes. CD1a antigen expression has been shown to be useful in
differentiating Langerhans cells, powerful antigen presenting cells present
in skin and epithelia, from interdigitating cells. Immunohistochemical studies
for CD1a antigen have reported a reduction in epidermal Langerhans cells in
graft versus host disease and the participation of CD1a in atherosclerotic
lesion formation and asthmatic inflammation.
Product Specific Information
Origin CD1a (Clone JPM30) is recommended for use in detecting CD1a protein
expression in a variety of normal and neoplastic tissues, including
Langerhans’ cell histiocytosis and thymomas.
Refer to page 70 for further information about Clone JPM30.
Origin CD1a (Clone JPM30) on skin. Paraffin section.
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CD3
Clone PS1
50 Tests ORG-8982 IVD
The CD3 antigen is a marker of T cell differentiation, expressed in normal
and neoplastic T cells. The CD3 antigen is first detected in early thymocytes
and its appearance probably represents one of the earliest indicators of
commitment to the T cell lineage.
Product Specific Information
T cell phenotype in lymphoproliferative disorders may be indicated using
Origin CD3 (Clone PS1) as part of a panel of antibodies.
Refer to page 70 for further information about Clone PS1.
Origin CD3 (Clone PS1) on tonsil. Paraffin section.
CD4
Clone 1F6
50 Tests ORG-8756 IVD
The CD4 antigen is expressed on a T cell subset (helper/inducer)
representing 45 percent of peripheral blood lymphocytes and at a lower
level on monocytes. Most cases of cutaneous T cell lymphoma, including
mycosis fungoides, express the CD4 antigen. HTLV-1 associated adult T cell
leukemia/lymphoma is also generally CD4 positive.
Origin CD4 (Clone 1F6) on tonsil.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.