Labelling Review row-Online

Cytokeratin 10
Clone LHP1
1 mL lyophilized NCL-CK10 F P (Enzyme)
Cytokeratin 10 is found in suprabasal layers of keratinizing stratified
epithelia. It is also found in a variable number of cells in suprabasal layers of
non-keratinizing stratified epithelia and is reported to be expressed in more
differentiated areas of some squamous carcinomas. Cytokeratin 10 is found
in various normal epithelia, including the anal canal, foot sole epidermis and
epidermises of other locations. Cytokeratin 10 is reported to be expressed in
ductal carcinoma of breast and squamous cell carcinoma of the ano-rectal
region.
Product Specific Information
NCL-CK10 reacts with the human cytokeratin intermediate filament protein
(56.5 kD) identified as cytokeratin 10.
Cytokeratin 13
Clone KS-1A3
0.5 mL lyophilized NCL-CK13 F P (HIER) W
Cytokeratin 13 is expressed as a major component of squamous, nonkeratinised
epithelium, transitional epithelium, pseudostratified epithelium
and myoepithelium. It is reported to be expressed in carcinomas of the
trachea, apocrine and eccrine sweat glands, salivary glands, reserve cells
of endocervical glands, bladder, ectocervix, tongue, esophagus, anal canal
and the basal layer of keratinised epidermis.
Product Specific Information
NCL-CK13 reacts with the acidic intermediate filament protein (54 kD)
identified as cytokeratin 13.
Cytokeratin 14
Clone LL002
1 mL, 0.1 mL lyophilized NCL-LL002 F P (HIER)
1 mL liquid NCL-L-LL002 F P (HIER)
Reference Range
Cytokeratins 14 and 5 are useful to distinguish stratified epithelial cell types
from simple epithelial cell types. Cytokeratin 14 has been reported to be
expressed in neoplasms of squamous cell origin.
Product Specific Information
Clone LL002 reacts with the human cytokeratin intermediate filament protein
(50 kD) identified as cytokeratin 14.
Cytokeratin 15
Clone LHK15
1 mL, 0.1 mL lyophilized NCL-CK15 F P (HIER)
Cytokeratin 15 is a 52 kD intermediate filament protein expressed only in
basal keratinocytes of stratified squamous epithelium, fetal epidermis and
fetal nail. It is a type I keratin and does not appear to have a natural type II
expression partner. All trichoepitheliomas, derived from hair follicle stem
cells, and approximately twenty five percent basal cell carcinomas are
reported to express cytokeratin 15. Squamous cell carcinomas are reported
not to express cytokeratin 15.
Normal human skin: immunohistochemical staining for cytokeratin 15 using NCL-CK15. Note
intense cytoplasmic staining of basal cells and hair follicles. Paraffin section.
Cytokeratin 16
Clone LL025
1 mL lyophilized NCL-CK16 F P (HIER)
Cytokeratins 16 and 6 are expressed where keratinocytes are undergoing
rapid turnover in the suprabasal region. Cytokeratins 16 and 6 are reported
to be found in various pathological states, including wound healing,
psoriasis and certain carcinomas.
Product Specific Information
NCL-CK16 reacts with the human cytokeratin intermediate filament protein
(48 kD) identified as cytokeratin 16.
Cytokeratin 17
Clone E3
1 mL, 0.1 mL lyophilized NCL-CK17 F P (HIER) W
7 mL Bond ready-to-use PA0114 P (HIER) New!
In normal tissues cytokeratin 17 is reported to be expressed in basal cells of
complex epithelia eg basal cells of pseudostratified epithelium in the
trachea, larynx, bronchi, myoepithelial cells in salivary glands and sweat
glands. In neoplastic tissue, cytokeratin 17 is reported to be expressed in
squamous cell carcinomas of the lung, cervix and oral cavity.
Product Specific Information
NCL-CK17 reacts with the human cytokeratin intermediate filament protein
(46 kD) identified as cytokeratin 17.
Refer to page 26 for the Bond ready-to-use format.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Primary Antibodies