Labelling Review row-Online

Squamous cell carcinoma: immunohistochemical staining with Bond ready-to-use Multi-
Cytokeratin (AE1/AE3) using Bond Polymer Refine Detection.
Multiple Myeloma Oncogene 1 (MUM-1)
Clone EAU32 New!
7 mL Bond ready-to-use PA0129 P (HIER)
For In Vitro Diagnostic Use
MUM-1 (Multiple Myeloma Oncogene 1)/FR4/ACSAT/PiP gene was originally
identified because of its involvement in the t(6:14) translocation observed in
multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the
Ig heavy chain locus. An antibody to MUM-1 indicates that the protein is
strongly expressed in late plasma cell directed stages of B cell
differentiation and in activated T cells and suggests that MUM-1 may serve
as a marker for lympho-hemopoietic neoplasms derived from these cells.
The morphologic spectrum of MUM-1 expressing cells has been found to
range from that of a centrocyte to that of a plasmablast/plasma cell.
Consequently the histogenic value of MUM-1 may be to provide a marker to
aid in the identification of the transition from BCL-6 positive (germinal center
B cells) to CD138 positive (immunoblasts and plasma cells). MUM-1
expression occurs in a wide range of lymphoid neoplasms including a
proportion of diffuse B cell lymphomas but not myeloid or extra hemopoietic
neoplasm's. MUM-1 is consistently expressed in myeloma cells, Reed
Sternberg cells in classic Hodgkin Disease, and normal and neoplastic
T cells.
Also available as a Novocastra concentrate, refer to page 136.
Hodgkin's lymphoma: immunohistochemical staining with Bond ready-to-use Multiple
Myeloma Oncogene 1 (MUM1) (EAU32) using Bond Polymer Refine Detection.
Muramidase (Lysozyme)
Polyclonal New!
7 mL Bond ready-to-use PA0391 P (Enzyme)
For In Vitro Diagnostic Use
Intracellular muramidase, also known as lysozyme, has been reported to be
expressed in myeloid and monocytic cells, in leukocytes and in myeloproliferative
disorders. Muramidase is also reported to be expressed in
poorly differentiated leukemic monoblasts.
Also available as a Novocastra concentrate, refer to page 129.
Acute myeloid leukemia: immunohistochemical staining with Bond ready-to-use Muramidase
(polyclonal) using Bond Polymer Refine Detection.
Muscle Specific Actin
Clone HHF35
7 mL Bond ready-to-use PA0258 P
For In Vitro Diagnostic Use
Actins are protein constituents of microfilaments, the ubiquitous cytoskeletal
elements present in most cells. Actins can be biochemically and
immunologically divided into three main subsets; alpha-actins are present in
muscle tissue, beta- and gamma-actins are present in non-muscle cells and
a minor subset of gamma-actins is present in muscle cells.
Product Specific Information
Muscle Specific Actin (PA0258) is specific for alpha- and gamma-actins of
smooth muscle (42 kD) reported to be expressed in striated muscle fibers of
the myocardium, skeletal muscle, arterial cell wall, smooth muscle coat of the
entire gastrointestinal tract, myometrial smooth muscle, prostatic stroma and
bladder wall.
Also available as a Novocastra concentrate, refer to page 138.
Leiomyosarcoma: immunohistochemical staining with Bond ready-to-use Muscle Specific
Actin (HHF35) using Bond Polymer Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
/35
Bond