Labelling Review row-Online

Origin
CD79a
Clone 11E3
50 Tests ORG-8975 IVD
CD79a is a cytoplasmic domain, disulfide linked heterodimer protein. This
protein is noncovalently associated with the membrane bound
immunoglobulins on B cells. This complex of polypeptides and
immunoglobulin constitutes the B cell receptor. The two components of this
complex are designated CD79a and CD79b. The CD79a antigen is reported to
first appear at the pre-B cell stage where it is found as an intracellular
component. The CD79a antigen is reported in the majority of acute
leukemias of precursor B cell types, B cell lines, B cell lymphomas and in
some myelomas. It is not present in myeloid or T cell lines.
Product Specific Information
An antibody panel including Origin CD79a (Clone 11E3) may be used in the
characterization of B cell disorders.
Refer to page 84 for further information about Clone 11E3.
Origin CD79a (Clone 11E3) on tonsil. Paraffin section.
Cytokeratin
Clone 34�E12
50 Tests ORG-8735 IVD
The expression of different cytokeratins in epithelial-derived tumors and the
general tendency towards maintenance of cytokeratin polypeptide patterns
during malignant growth and metastasis serves as a basis for approaching
the characterization of tumors, using cytokeratins as differentiation markers.
Product Specific Information
Origin Cytokeratin (Clone 34�E12) is recommended for the characterization of
squamous and ductal carcinomas arising from complex epithelia and is of
value in the differentiation of benign and malignant small-acinar lesions of the
prostate gland.
Refer to page 137 for further information about Clone 34�E12.
Origin Cytokeratin (Clone 34�E12) on squamous cell carcinoma. Paraffin section.
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Desmin
Clone DE-R-11
50 Tests ORG-8889 IVD
Human desmin is a 53 kD cytoplasmic intermediate filament protein in
striated and smooth muscle cells. It is confined to the Z bands in skeletal
and cardiac muscle giving a characteristic striated appearance when
immunohistochemically stained.
Product Specific Information
Origin Desmin (Clone DE-R-11) is recommended as an aid in the determination
of tumors of myogenic origin, such as those arising from smooth muscle,
leiomyomas and those derived from striated muscle. The antibody does not
recognize other intermediate filament proteins.
Refer to page 101 for further information about Clone DE-R-11.
Origin Desmin (Clone DE-R-11) on bowel. Paraffin section.
Estrogen Receptor
Clone 6F11
50 Tests ORG-8871 IVD
Estrogen receptor (ER) expression in breast cancer tissue is an important
parameter in the prediction and response to endocrine therapy. Monoclonal
antibodies to ER have allowed the determination of ER status to be carried
out in routine histopathology laboratories quantitatively and qualitatively.
Product Specific Information
Origin Estrogen Receptor (Clone 6F11) is indicated as an aid in prognosis and
prediction of therapy in breast cancer, it binds specifically to the ER alpha
antigen in the nuclei of normal and neoplastic tissues.
Refer to page 106 for further information about Clone 6F11.
Origin Estrogen Receptor (Clone 6F11) on breast carcinoma. Paraffin section.
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This catalog is not for use in the USA.