Labelling Review row-Online

Bond
CA19-9 (Sialyl Lewis a)
Clone C241:5:1:4
7 mL Bond ready-to-use PA0424 P (HIER)
For In Vitro Diagnostic Use
CA19-9 is an epitope on the sialylated Lewis a carbohydrate structure.
Sialylated Lewis a plays a role in cell adhesion by acting as a functional
ligand for the inducible adhesion molecule E-selectin. CA19-9 and CA50
(carcinoma associated mucin antigen) are useful serum markers in the
diagnosis and follow up of gastrointestinal and pancreatic cancers. In
carcinoma of the pancreas, it is reported that the immunohistochemical
expression of both CA19-9 and CA50 correlates with tumor differentiation
where the strongest staining is observed in well differentiated tumors.
These two markers are also reported in a number of benign lesions such as
chronic pancreatitis.
Product Specific Information
Clone C241:5:1:4 reacts specifically with glycolipids containing Sialyl Lewis a ,
showing no cross-reaction with Lewisa , Lewisb , or other structurally related
molecules. The epitope recognized by CA19-9 (Sialyl Lewisa ) is designated
CA19-9 and is similar to CA50 (carcinoma associated mucin antigen).
Also available as a Novocastra concentrate, refer to page 64.
Adenocarcinoma: immunohistochemical staining with Bond ready-to-use CA19-9 (Sialyl
Lewis a ) (C241:5:1:4) using Bond Polymer Refine Detection.
CA125
Clone Ov185:1
7 mL Bond ready-to-use PA0539 P (HIER)
For In Vitro Diagnostic Use
CA125 is also known as MUC16. CA125 antigen is usually associated with
ovarian epithelial malignancies. Serum assays are widely used to detect this
protein in the monitoring of ovarian cancers. CA125 antigen may also be
detected by immunohistochemistry and expression has been found in
neoplasms such as seminal vesicle carcinoma and anaplastic lymphoma.
CA125 antigen is not found exclusively in malignant tumors.
Also available as a Novocastra concentrate, refer to page 64.
Mucinous adenocarcinoma: immunohistochemical staining with Bond ready-to-use CA125
(Ov185:1) using Bond Polymer Refine Detection.
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Calcitonin
Polyclonal
7 mL Bond ready-to-use PA0406 P (Enzyme)
For In Vitro Diagnostic Use
Calcitonin is a peptide hormone synthesized by the parafollicular cells of the
thyroid. It causes reduction in serum calcium, an effect opposite to that of
parathyroid hormone (PTH). Calcitonin has been reported to be
demonstrated in C cells of normal and hyperplastic thyroid. Staining for
calcitonin may be used for the identification of a spectrum of C cell
proliferative abnormalities ranging from C cell hyperplasia to invasive
tumors.
Also available as a Novocastra concentrate, refer to page 65.
Medullary carcinoma: immunohistochemical staining with Bond ready-to-use Calcitonin
(Polyclonal) using Bond Polymer Refine Detection.
Calponin (Basic)
Clone 26A11
7 mL Bond ready-to-use PA0416 P (HIER)
For In Vitro Diagnostic Use
Calponin (Basic) is an actin, tropomyosin and calmodulin binding protein
thought to be involved in the regulation of smooth muscle contraction. The
expression of basic calponin is reported to be restricted to smooth muscle
cells and is a marker of the differentiated contractile phenotype of
developing smooth muscle. Vascular smooth muscle cells convert to a
synthetic dedifferentiated phenotype when this protein is lost and this is a
key stage in both atherosclerosis and restenosis of coronary arteries after
balloon angioplasty. It is thought that basic calponin exerts its effect via the
cortical actin cytoskeleton and therefore influences proliferation, the
transformed phenotype and the metastatic potential of tumor cells. Basic
calponin mRNA is expressed in smooth muscle of prostate, bowel and aorta
whereas neutral and acidic calponin mRNAs are expressed in non-smooth
muscle tissues such as heart, placenta, lung, kidney, pancreas, spleen,
testis and ovary as well as in smooth muscle-containing tissues.
Also available as a Novocastra concentrate, refer to page 66.
Breast carcinoma: immunohistochemical staining with Bond ready-to-use Calponin (Basic)
(26A11) using Bond Polymer Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.