Labelling Review row-Online

Human Wilms’ tumor: immunohistochemical staining for WT1 using NCL-L-WT1-562.
Note intense nuclear staining of malignant cells. Paraffin section.
Zap-70
Clone L453R
1 mL, 0.1 mL liquid NCL-L-ZAP-70 P (HIER) W
7 mL Bond ready-to-use PA0998 P (HIER)
Reference Range
ZAP-70 is a member of the syk family of proteins. It is expressed on T cells
and NK cells and is required for the T cell receptor activation that triggers
an immune response. CLL B cells that express the non-mutated
immunoglobulin VH genes express levels of ZAP-70 protein that are
comparable to those found in the blood T cells of healthy adults. Leukemic
cells that express mutated IgVH genes generally do not express detectable
levels of ZAP-70 protein and this is correlated with the high level expression
of CD38. The ZAP-70 positive sub-type has been reported to be associated
with a more aggressive phenotype.
Refer to page 44 for the Bond ready-to-use format.
Human B cell chronic lymphocytic leukemia: immunohistochemical staining for ZAP-70 antigen
using NCL-L-ZAP-70. Note staining of malignant lymphocytic leukemic cells and intense
staining of infiltrating T lymphocytes. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
/ 171
Primary Antibodies