Labelling Review row-Online

Calretinin
Clone CAL6
7 mL Bond ready-to-use PA0346 P (HIER)
For In Vitro Diagnostic Use
Calretinin is a calcium-binding protein of 29 kD, reported to be abundantly
expressed in neurons. Outside the nervous system, calretinin expression
has been demonstrated in a range of cell types including mesothelial cells,
steroid producing cells, some neuroendocrine cells, eccrine sweat glands
and other cell types. The presence of calretinin is reported to be a useful
marker primarily for two purposes: differentiating malignant mesothelioma
from carcinomas; and the differential characterization of ovarian stromal
tumors. Calretinin-positive cells have also been reported in the convoluted
tubules of kidney with some antibodies.
Product Specific Information
Bond ready-to-use Calretinin (CAL6) is recommended for use as part of an
antibody panel for the identification of mesothelioma.
Also available as a Novocastra concentrate, refer to page 66.
Mesothelioma: immunohistochemical staining with Bond ready-to-use Calretinin (CAL6) using
Bond Polymer Refine Detection.
Carcinoembryonic Antigen
Clone II-7
7 mL Bond ready-to-use PA0004 P (HIER)
For In Vitro Diagnostic Use
Carcinoembryonic antigen (CEA) is a heterogeneous cell surface
glycoprotein produced by cells of fetal colon. Low levels are also found on
normal mucosal epithelia of the adult colon and a variety of other normal
tissues. CEA is encoded by the CEA gene that is located on chromosome 19.
It is a member of the CEA gene family, which in turn is a subfamily of the
immunoglobulin superfamily. Cell adhesion properties are now well
recognized for CEA. It is believed that the expression of this glycoprotein in
conjunction with other known adhesion molecules will influence the cellcell
interaction.
Also available as a Novocastra concentrate, refer to page 67.
Colon adenocarcinoma: immunohistochemical staining with Bond ready-to-use
Carcinoembryonic Antigen (II-7) using Bond Polymer Refine Detection.
CD1a
Clone MTB1
7 mL Bond ready-to-use PA0235 P (HIER)
For In Vitro Diagnostic Use
CD1a is a protein of 43–49 kD expressed on dendritic cells and cortical
thymocytes. CD1a expression has been shown to be useful in the differentiation
of Langerhans’ cells and interdigitating cells in the skin.
Product Specific Information
Bond ready-to-use CD1a (MTB1) is recommended for use in detecting CD1a
protein expression in a variety of normal and neoplastic tissues, including
Langerhans' cell histiocytosis and thymomas.
Also available as a Novocastra concentrate, refer to page 70.
Skin: immunohistochemical staining with Bond ready-to-use CD1a (MTB1) using Bond Polymer
Refine Detection.
CD2
Clone 11F11
7 mL Bond ready-to-use PA0271 P (HIER)
For In Vitro Diagnostic Use
The CD2 antigen is an accessory molecule, important in mediating the
adhesion of activated T cells and thymocytes with antigen-presenting cells
and target cells.
Product Specific Information
CD2 (11F11) is recommended for use as part of an antibody panel in the
characterization of T cell disorders.
Also available as a Novocastra concentrate, refer to page 70.
Tonsil: immunohistochemical staining with Bond ready-to-use CD2 (11F11) using Bond Polymer
Refine Detection.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Bond