Labelling Review row-Online

CDX2
Clone AMT28
1 mL, 0.1 mL lyophilized NCL-CDX2 P (HIER)
7 mL Bond ready-to-use PA0535 P (HIER)
CDX2 is a caudal-type homeobox, intestine-specific transcription factor that
is expressed early in intestinal development and may be involved in the
regulation of proliferation and differentiation of intestinal epithelial cells.
CDX2, as well as CDX1, is of particular interest as the intestine is the only
organ that contains detectable levels of either gene product. This pattern of
restricted expression is unusual for homeobox genes. Phosphorylation of
the CDX2 activation domain can modulate its function and different spatial
expression patterns in the intestinal epithelium. CDX2 is primarily expressed
on the surface of the villus and in the crypts. In contrast to CDX1, intense
CDX2 expression is reported to occur in all but the distal portions of the
developing intestine. The loss of CDX2 has been reported to contribute
towards the progression of some sporadic colorectal cancers. It has been
reported that CDX2 may also be associated with carcinogenesis of the
stomach as expression of CDX2 mRNA progressively decreases with the
transition from well differentiated to poorly differentiated gastric cancer cell
lines.
Refer to page 25 for the Bond ready-to-use format.
Human small intestine: immunohistochemical staining for CDX2 homeobox protein using
NCL-CDX2. Note nuclear and cytoplasmic staining of epithelial cells. Paraffin section.
CEACAM1 (CD66a)
Clone 29H2
1 mL lyophilized NCL-CD66a P (HIER)
See also CD66a (CEACAM1) on page 82.
Cellular Apoptosis Susceptibility Protein
Clone 30F12
1 mL lyophilized NCL-CAS F P (HIER) W
Reference Range
Cellular apoptosis susceptibility protein, the product of the CAS gene, is
associated with microtubules and the mitotic spindle. CAS is the human
homolog of the yeast chromosome-segregation gene, CSE-1. The molecular
mechanism or function by which CAS is associated with cell proliferation
and apoptosis is not yet fully understood but it has been proposed that the
protein may play a role in the development of some leukemias and
lymphomas. Aggressive non-Hodgkin's lymphoma and Hodgkin's disease
have been reported where up to 80 percent of the malignant cells express
CAS protein. These include large cell anaplastic lymphomas of T and null
cell phenotype and diffuse large B cell lymphomas. Low grade non-
Hodgkin's lymphoma were reported where only 10 to 60 percent of all cells
were positive. It was proposed that high expression of cytoplasmic CAS
protein appeared to correlate with proliferation of normal and malignant
lymphoid cells.
Human breast carcinoma: immunohistochemical staining for cellular apoptosis susceptibility
protein using NCL-CAS. Note cytoplasmic and nuclear staining of proliferating tumor cells.
Paraffin section.
c-erbB-2 Oncoprotein (HER-2)
Antibodies
Clone 5A2
1 mL lyophilized HER-2 (internal domain)
NCL-c-erbB-2-316 FP
Clone CB11
1 mL, 0.1 mL lyophilized HER-2 (internal domain)
NCL-CB11 FPC
1 mL liquid HER-2 (internal domain)
NCL-L-CB11 FPC
Reference Range
7 mL ready-to-use HER-2 (internal domain) RTU-CB11 FP
60 Tests Oracle HER2 Bond IHC System TA9145
Clone 10A7
1 mL, 0.1 mL lyophilized HER-2 (external domain)
NCL-CBE-356 PW
1 mL liquid HER-2 (external domain) NCL-L-CBE-356 PW
7 mL ready-to-use HER-2 (external domain) RTU-CBE-356 P
Clone CBE1
1 mL lyophilized HER-2 (external domain)
NCL-CBE1 F P (HIER)
Polyclonal
0.2 mL lyophilized HER-2 (internal domain) NCL-PC11 FP
See also HER-2 (c-erbB-2 Oncoprotein) Antibodies on page 119.
For more information on the Oracle HER2 Bond IHC System see page 11.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Primary Antibodies