Labelling Review row-Online

Bond
CD3
Clone LN10
7 mL Bond ready-to-use PA0553 P (HIER)
For In Vitro Diagnostic Use
The CD3 antigen is a marker of T cell differentiation. It is first detected in
early thymocytes and its appearance is thought to represent one of the
earliest signs of commitment to the T cell lineage.
Product Specific Information
Bond ready-to-use CD3 (LN10) has been specifically designed to supercede
Novocastra clone PS1 and produce an unrivaled stain on formalin-fixed,
paraffin-embedded tissue.
CD3 (LN10) can be employed in the characterization of T cell disorders as one
component of a panel of antibodies.
Also available as a Novocastra concentrate, refer to page 70.
Tonsil: immunohistochemical staining with Bond ready-to-use CD3 (LN10) using Bond Polymer
Refine Detection.
CD4
Clone 4B12
7 mL Bond ready-to-use PA0368 P (HIER)
For In Vitro Diagnostic Use
The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a
molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset
(helper/inducer) representing 45 percent of peripheral blood lymphocytes
and at a lower level on monocytes. Most cases of cutaneous T cell
lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1
associated adult T cell leukemia/lymphoma is also generally CD4 positive.
Also available as a Novocastra concentrate, refer to page 71.
Tonsil, T cell helper/inducer cells: immunohistochemical staining with Bond ready-to-use CD4
(4B12) using Bond Polymer Refine Detection.
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CD5
Clone 4C7
7 mL Bond ready-to-use PA0168 P (HIER)
For In Vitro Diagnostic Use
In normal lymphoid tissue CD5 is expressed mainly on T cells. It is reported
to be expressed in 95 percent of thymocytes and in a subset of B cells,
located primarily in the mantle zones.
CD5 expression has been described in some T and B lymphomas, however
antibodies to CD5 have been found to be useful in antibody panels for the
differential diagnosis of small B cell lymphomas.
Also available as a Novocastra concentrate, refer to page 71.
Tonsil: immunohistochemical staining with Bond ready-to-use CD5 (4C7) using Bond Polymer
Refine Detection.
CD7
Clone LP15
7 mL Bond ready-to-use PA0266 P (HIER)
For In Vitro Diagnostic Use
The CD7 molecule is a membrane-bound glycoprotein of 40 kD and is the
earliest T cell specific antigen to be expressed in lymphocytes. CD7 antigen
is also the only early marker to persist throughout differentiation. The
function and role of the CD7 molecule has not yet been fully identified,
although the activation of T cells with gamma/delta receptors has been
proposed based on mAb-induced activation. CD7 antigen is reported to be
found on the majority of peripheral blood T cells, most natural killer cells and
thymocytes.
Also available as a Novocastra concentrate, refer to page 72.
Tonsil: immunohistochemical staining with Bond ready-to-use CD7 (LP15) using Bond Polymer
Refine Detection.
Products in this catalog are subject to regulatory approval.
This catalog is not for use in the USA.