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Vol.XXXVII, Suppl. 1 - Giornale Italiano di Ortopedia e Traumatologia

Vol.XXXVII, Suppl. 1 - Giornale Italiano di Ortopedia e Traumatologia

Vol.XXXVII, Suppl. 1 - Giornale Italiano di Ortopedia e Traumatologia

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s120<br />

scheletriche in quanto ancora molti sono gli aspetti da<br />

chiarire circa il loro utilizzo.<br />

Primo fra tutti, la tecnica <strong>di</strong> estrazione dei fattori <strong>di</strong> crescita<br />

autologhi. Come già accennato, in commercio è possibile<br />

trovare sistemi per ottenere PRP ben <strong>di</strong>fferenti tra loro per<br />

<strong>di</strong>versi parametri come la concentrazione fi nale <strong>di</strong> piastrine,<br />

l’utilizzo <strong>di</strong> attivatori o la presenza più o meno evidente<br />

<strong>di</strong> leucociti, monociti o macrofagi contenuti nel PRP.<br />

Un punto, secondo noi cruciale, nell’utilizzo delle tera-<br />

Bibliografi a<br />

1 Molloy T, Wang Y, Murrel G. The role of<br />

growth factors in tendon and ligament healing.<br />

Sports Med 2003;33:381-94.<br />

2 Foster TE, Puskas BL, Mendelbaum BR, et al.<br />

Platelet-rich Plasma: From basic science<br />

to clinical application. Am J Sports Med<br />

2009;37:2259-72.<br />

3 Lopez-Vidriero E, Goul<strong>di</strong>ng KA, Simon DA,<br />

et al. The use of platelet-rich plasma in arthroscopy<br />

and sports me<strong>di</strong>cine: optimizing<br />

the healing environment. Arthroscopy<br />

2010;26:269:78.<br />

4 Chen CH, Cao Y, Wu YF, et al. Tendon<br />

healing in vivo:Gene expression and production<br />

of multiple growth factors in early<br />

tendon healing period. J Hand Surg Am<br />

2008;33:1834-42.<br />

5 Kon E, Filardo G, Delcogliano M, et al. Platelet-rich<br />

plasma: new clinical application:a<br />

pilot study for treatmento of jumper’s knee.<br />

Injury 2009;40:598-603.<br />

6 Filardo G, Presti ML, Kon E, et al. Nonoperative<br />

biological treatment approach for<br />

partial Achilles tendon lesion. Orthope<strong>di</strong>cs<br />

2010;33:120-3.<br />

7 Randelli P, Arrigoni P, Cabitza P, et al. Autologous<br />

platelet rich plasma for arthroscopic<br />

rotator cuff repair. A pilot study. Disabil Rehabil<br />

2008;30:1584-9.<br />

8 Sanchez M, Anitua E, Azofra J, et al. Com-<br />

p. VoLpi Et aL.<br />

parison of surgically repaired Achilles tendon<br />

tears using platelet-rich fi brin matrices.<br />

Am J Sports 2007;35:245-51.<br />

9 Mishra A, Pavelko T. Treatment of chronic<br />

elbow ten<strong>di</strong>nosis with buffered pltelet rich<br />

plasma. Am J Sport Med 2006:34;1774-8.<br />

10 De Vos RJ, Weir A, van Schie HT, et al. Platelet-rich<br />

plasma injection for chronic Achilles<br />

ten<strong>di</strong>nopathy: a randomized controlled trial.<br />

JAMA 2010;303:144-9.<br />

11 <strong>Vol</strong>pi P, Marinoni L, Bait C, et al. Treatment<br />

of chronic patellar ten<strong>di</strong>nosis with buffered<br />

platelet rich plasma: a preliminary study.<br />

Med Sport 2007;60:595-603.<br />

12 <strong>Vol</strong>pi P, Quaglia A, Schoenhuber H, et al.<br />

Growth factors in the managment of sport induced<br />

ten<strong>di</strong>nopathies: Result after 24 month<br />

from treatment. A pilot study. Sports Med<br />

Phys Fitness 2010;50:494-500.<br />

13 Kasemkijwattana C, Menetrey J, Bosch P,<br />

et al. Use of growth factors to improve muscle<br />

healing after strain injury. Clin Orthop<br />

Relat Res 2000;370:272-85.<br />

14 Wright-Carpenter T, Popolon P, Appell HJ,<br />

et al. Treatment of muscle injury by local administration<br />

of autologous con<strong>di</strong>tioned serum:<br />

Animal experimnts using a muscle contusion<br />

model. Int J portr Med 2004;25:582-7.<br />

15 Hammond JW, Hinton RY, Curl LA, et al.<br />

Use of autologous platelet-rich plasma to treatr<br />

muscle strain injuries. Am J Soprts Med<br />

2009;37:1135-42.<br />

pie biologiche consiste nello stabilire non tanto i tempi<br />

con cui avvengono i processi riparativi e rigenerativi,<br />

ma soprattutto nel consentire una guarigione tissutale<br />

biologica e biomeccanica più vicina possibile ai tessuti<br />

originali.<br />

Per questi motivi, sono necessari nuovi approfon<strong>di</strong>menti<br />

attraverso stu<strong>di</strong> clinici appropriati che permettano <strong>di</strong> poter<br />

<strong>di</strong>sporre <strong>di</strong> in<strong>di</strong>cazioni e risultati maggiormente affi -<br />

dabili.<br />

16 Sanchez M, Anitua E, An<strong>di</strong>a I, et al. Application<br />

of autologous growth factors on skeltal<br />

muscle healing. Presented at the second<br />

international Conference on rigenerative<br />

me<strong>di</strong>cine, Leipzig, Germania, 18-20 Maggio<br />

2005.<br />

17 De Carli A, <strong>Vol</strong>pi P, Pelosini I, et al. New<br />

therapeutic approaches for management<br />

of Sport-induced muscle strains. Adv Ther<br />

2009;26:1072-83.<br />

18 Ra<strong>di</strong>ce F, Gutierrez V, Ibarra A, et al. Arthroscopic,<br />

histologic and MRI correlation<br />

in the maturation process of the graft in<br />

ACL reconstruction in humans. Arthroscopy<br />

1998;14(<strong>Suppl</strong> 1):S20.<br />

19 Arnoczky SP, Anderson L, Fanelli G, et al.<br />

The role of platelet rich plasma in connnetive<br />

tissuee repair. Orthope<strong>di</strong>cs Today<br />

2009;26:29.<br />

20 Cervellin M, Bait C, Denti M, et al. Evaluation<br />

of Autologous platelet-rich plasma gel<br />

to reduce donor site morbi<strong>di</strong>ty after patellar<br />

tendon graft harvesting for anterior cruciate<br />

ligament reconstruction: a randomized,<br />

controlled clinical study. 2011 Accepted by<br />

ESKKA.<br />

21 Galliera E, de Girolamo L, Randelli P. High<br />

articular level of the angiogenetic factors<br />

VEGF and VEGF receptors 2 as tissue healing<br />

biomarkers after single bundle anterior<br />

cruciate ligament reconstruction. J Biol Regul<br />

Homeost Agents 2011;25:85-91.

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