Vol.XXXVII, Suppl. 1 - Giornale Italiano di Ortopedia e Traumatologia
Vol.XXXVII, Suppl. 1 - Giornale Italiano di Ortopedia e Traumatologia
Vol.XXXVII, Suppl. 1 - Giornale Italiano di Ortopedia e Traumatologia
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s120<br />
scheletriche in quanto ancora molti sono gli aspetti da<br />
chiarire circa il loro utilizzo.<br />
Primo fra tutti, la tecnica <strong>di</strong> estrazione dei fattori <strong>di</strong> crescita<br />
autologhi. Come già accennato, in commercio è possibile<br />
trovare sistemi per ottenere PRP ben <strong>di</strong>fferenti tra loro per<br />
<strong>di</strong>versi parametri come la concentrazione fi nale <strong>di</strong> piastrine,<br />
l’utilizzo <strong>di</strong> attivatori o la presenza più o meno evidente<br />
<strong>di</strong> leucociti, monociti o macrofagi contenuti nel PRP.<br />
Un punto, secondo noi cruciale, nell’utilizzo delle tera-<br />
Bibliografi a<br />
1 Molloy T, Wang Y, Murrel G. The role of<br />
growth factors in tendon and ligament healing.<br />
Sports Med 2003;33:381-94.<br />
2 Foster TE, Puskas BL, Mendelbaum BR, et al.<br />
Platelet-rich Plasma: From basic science<br />
to clinical application. Am J Sports Med<br />
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3 Lopez-Vidriero E, Goul<strong>di</strong>ng KA, Simon DA,<br />
et al. The use of platelet-rich plasma in arthroscopy<br />
and sports me<strong>di</strong>cine: optimizing<br />
the healing environment. Arthroscopy<br />
2010;26:269:78.<br />
4 Chen CH, Cao Y, Wu YF, et al. Tendon<br />
healing in vivo:Gene expression and production<br />
of multiple growth factors in early<br />
tendon healing period. J Hand Surg Am<br />
2008;33:1834-42.<br />
5 Kon E, Filardo G, Delcogliano M, et al. Platelet-rich<br />
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Injury 2009;40:598-603.<br />
6 Filardo G, Presti ML, Kon E, et al. Nonoperative<br />
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7 Randelli P, Arrigoni P, Cabitza P, et al. Autologous<br />
platelet rich plasma for arthroscopic<br />
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2008;30:1584-9.<br />
8 Sanchez M, Anitua E, Azofra J, et al. Com-<br />
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10 De Vos RJ, Weir A, van Schie HT, et al. Platelet-rich<br />
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pie biologiche consiste nello stabilire non tanto i tempi<br />
con cui avvengono i processi riparativi e rigenerativi,<br />
ma soprattutto nel consentire una guarigione tissutale<br />
biologica e biomeccanica più vicina possibile ai tessuti<br />
originali.<br />
Per questi motivi, sono necessari nuovi approfon<strong>di</strong>menti<br />
attraverso stu<strong>di</strong> clinici appropriati che permettano <strong>di</strong> poter<br />
<strong>di</strong>sporre <strong>di</strong> in<strong>di</strong>cazioni e risultati maggiormente affi -<br />
dabili.<br />
16 Sanchez M, Anitua E, An<strong>di</strong>a I, et al. Application<br />
of autologous growth factors on skeltal<br />
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me<strong>di</strong>cine, Leipzig, Germania, 18-20 Maggio<br />
2005.<br />
17 De Carli A, <strong>Vol</strong>pi P, Pelosini I, et al. New<br />
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18 Ra<strong>di</strong>ce F, Gutierrez V, Ibarra A, et al. Arthroscopic,<br />
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1998;14(<strong>Suppl</strong> 1):S20.<br />
19 Arnoczky SP, Anderson L, Fanelli G, et al.<br />
The role of platelet rich plasma in connnetive<br />
tissuee repair. Orthope<strong>di</strong>cs Today<br />
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20 Cervellin M, Bait C, Denti M, et al. Evaluation<br />
of Autologous platelet-rich plasma gel<br />
to reduce donor site morbi<strong>di</strong>ty after patellar<br />
tendon graft harvesting for anterior cruciate<br />
ligament reconstruction: a randomized,<br />
controlled clinical study. 2011 Accepted by<br />
ESKKA.<br />
21 Galliera E, de Girolamo L, Randelli P. High<br />
articular level of the angiogenetic factors<br />
VEGF and VEGF receptors 2 as tissue healing<br />
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cruciate ligament reconstruction. J Biol Regul<br />
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