Abstract 230 - IMPIEGO DEI GLICOPEPTIDI NELLA ... - SIMIT

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10° CONGRESSO NAZIONALE SIMIT
Abstract 216
- INFLUENCE OF DIFFERENT ART REGIMENS ON IMMUNE PARAMETERS AND
ACTIVATION: ABACAVIR, TENOFOVIR AND RALTEGRAVIR –BASED REGIMENS
AND NK CELLS -
Bozzano F. [1] , Marras F. [2] , Beltrame A. [3] , Alessandrini A. [3] , Pagano G. [3] , De Maria A.* [4]
- [1] ISTITUTO SCIENTIFICO G.GASLINI ~ GENOVA - [2] CENTRO DI ECCELLENZA PER LA RICERCA BIOMEDICA-
UNIVERSITA' DEGLI STUDI DI GENOVA ~ GENOVA - [3] Azienda Ospedaliera- Ospedale San Martino ~ GENOVA -
[4] ISTITUTO TUMORI ~ GENOVA
INFEZIONI DA HIV
Premessa: Background: antiretroviral treatment (ART) has been shown to interfere with
several parameters involved in homeostasis of metabolic and inflammatory pathways, as
well as with cell proliferation. Innate immune function may be variably influenced by
antiretroviral targeting different viral and metabolic pathways.
Obiettivo: Aims: for these reasons we studied peripheral NK cells in patients on different
ART regimens to understand its possible modulation of the immune response.
Risultati: Results: Patients falling into the 3 treatment groups were enrolled. Mean CD4+
cell counts were comparable in ABC and TDF and were lower in RAL patients
respectively.
Among patients in ABC and TDF, NKp46, NKp30, NKG2D and DNAM-1, NK cell receptor
expression was comparable. CD85j, NKG2A/CD94 inhibitory receptors were comparable
in patients belonging to the two groups. Increased NK cell activation (HLA-DR expression),
decreased cytotoxicity and IFN? production were observed among patients in TDF
compared to ABC.
Patients in RAL had more advanced disease according to CD4+ proportions and absolute
counts, as expected. However, they had the least activation of NK cells, when compared
to ABC patients or TDF. Reduced proportions of NKp30, NKG2D, DNAM-1 were also
recorded in this group when compared to the other patients. In addition, they showed
decreased CD85j, NKG2A/CD94 receptors expression on NK cells compared to the other
patients.
Conclusione: Conclusions: These preliminary data suggest that among stably treated
patients on different ART regimens, ART may exert different immunomodulating effects in
addition to their primary antiretroviral activity. Effects on NK cells may affect the antigen
presentation and adaptive immune response to HIV itself and other recall antigens, as
well as to new antigens (e.g. vaccination, tumor). Knowledge of ART effects on innate
immune mechanisms may be suitably exploited in HIV patients according to clinical needs.